| 规格或纯度 | 98% |
|---|---|
| 英文名称 | Harmine |
| 别名 | 骆驼蓬碱 |
| 英文别名 | HARMINE|442-51-3|7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole|Banisterine|Telepathine|Leucoharmine|Yageine|Yajeine|9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-|7-Methoxy-1-methyl-9H-beta-carboline|Harmin|Harmine (Telepathine)|Banisterin|Telepathin|7-Methoxy-1 |
| 生化机理 | DYRK1A的强效和选择性抑制剂（酪氨酸磷酸化和调节的双重特异性激酶）。（IC 50值为0.08（DYRK1A），0.9（DYRK2），0.8（DYRK3），4.3（PIM3）和1.5μM（CK1））。5-HT拮抗剂和MAO抑制剂。 |
| 运输条件 | 常规运输 |
| 备注 | 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| 产品介绍 |
不溶于水。中枢神经系统兴奋剂。 |
| EC号 | 207-131-4 |
|---|---|
| IUPAC Name | 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole |
| INCHI | InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3 |
| InChi Key | BXNJHAXVSOCGBA-UHFFFAOYSA-N |
| Canonical SMILES | CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC |
| WGK Germany | 3 |
| RTECS | UV0175000 |
| 关联CAS | 442-51-3 |
| PubChem CID | 5280953 |
| MeSH Entry Terms | 9H-Pyrido(3,4-b)indole, 7-methoxy-1-methyl-;Banisterine;Harmine;Leucoharmine;Telepathine;Yageine |
| 分子量 | 212.25 |
| Beilstein号 | 178813 |
| 密度 | 1.252 |
|---|---|
| 熔点 | 262-264°C |
| 象形图 |
Harmful |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H319: Causes serious eye irritation H302: Harmful if swallowed H312: Harmful in contact with skin H332: Harmful if inhaled |
| 预防措施声明 | P261,P305+P351+P338,P280,P302+P352,P321,P501,P264,P271,P270,P304+P340,P362+P364,P330,P264+P265,P301+P317,P317,P337+P317 |
| WGK Germany | 3 |
| RTECS | UV0175000 |
| Merck Index | 4616 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Gloves |
| Ligand ID | 9352 |
|---|---|
| 名称 | harmine |
| 类别 | Natural product |
| 学名 | 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole |
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| 评价 |
Harmine is a plant-derived β-carboline alkaloid that has psychoactive activity. It has been reported as an inhibitor of dual specificity tyrosine phosphorylation regulated kinases of the Dyrk1 subfamily |
| 1. Miralles A, Esteban S, Sastre-Coll A, Moranta D, Asensio VJ, García-Sevilla JA. (2005) High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain.. Eur J Pharmacol, 518 (2-3): (234-42). [PMID:16061219] |
| 2. G?ckler N, Jofre G, Papadopoulos C, Soppa U, Tejedor FJ, Becker W. (2009) Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation.. FEBS J, 276 (21): (6324-37). [PMID:19796173] |
| 3. Liu X, Li M, Tan S, Wang C, Fan S, Huang C. (2017) Harmine is an inflammatory inhibitor through the suppression of NF-κB signaling.. Biochem Biophys Res Commun, 489 (3): (332-338). [PMID:28551404] |
| 4. Jiang B, Meng L, Zou N, Wang H, Li S, Huang L, Cheng X, Wang Z, Chen W, Wang C. (2019) Mechanism-based pharmacokinetics-pharmacodynamics studies of harmine and harmaline on neurotransmitters regulatory effects in healthy rats: Challenge on monoamine oxidase and acetylcholinesterase inhibition.. Phytomedicine, 62 (13): (152967). [PMID:31154274] |
| 5. Ferraz CAA, de Oliveira Júnior RG, Picot L, da Silva Almeida JRG, Nunes XP. (2019) Pre-clinical investigations of β-carboline alkaloids as antidepressant agents: A systematic review.. Fitoterapia, 137 (13): (104196). [PMID:31175948] |
| 6. Herraiz T, Guillén H. (2018) Monoamine Oxidase-A Inhibition and Associated Antioxidant Activity in Plant Extracts with Potential Antidepressant Actions.. Biomed Res Int, 2018 (13): (4810394). [PMID:29568754] |
| 7. Yamamoto T et al.. (2017) Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks.. FEBS Lett, 591 (6): (842-853). [PMID:28194753] |
| 8. Kim MJ et al.. (2021) PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis.. Mol Cell, 81 (8): (1698-1714.e6). [PMID:33626321] |
| 9. Tam BY, Chiu K, Chung H, Bossard C, Nguyen JD, Creger E, Eastman BW, Mak CC, Ibanez M, Ghias A et al.. (2020) The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models.. Cancer Lett, 473 (13): (186-197). [PMID:31560935] |
| 10. Bain J, Plater L, Elliott M, Shpiro N, Hastie CJ, McLauchlan H, Klevernic I, Arthur JS, Alessi DR, Cohen P. (2007) The selectivity of protein kinase inhibitors: a further update.. Biochem J, 408 (3): (297-315). [PMID:17850214] |
| 11. Pozo N et al.. (2013) Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth.. J Clin Invest, 123 (6): (2475-87). [PMID:23635774] |
| 12. J Ott. (1999-08-07) Pharmahuasca: human pharmacology of oral DMT plus harmine.. Journal of psychoactive drugs, 31 ((2)): (171-177). [PMID:10438001] |
| 13. Johannes Kornhuber,Philipp Tripal,Martin Reichel,Lothar Terfloth,Stefan Bleich,Jens Wiltfang,Erich Gulbins. (2007-11-22) Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.. Journal of medicinal chemistry, 51 ((2)): (219-237). [PMID:18027916] |
| 14. Qifeng Wu,Rihui Cao,Manxiu Feng,Xiangdong Guan,Chunming Ma,Jinbing Liu,Huacan Song,Wenlie Peng. (2008-05-09) Synthesis and in vitro cytotoxic evaluation of novel 3,4,5-trimethoxyphenyl substituted beta-carboline derivatives.. European journal of medicinal chemistry, 44 ((2)): (533-540). [PMID:18462839] |
| 15. Betty C Galarreta,Roxana Sifuentes,Angela K Carrillo,Luis Sanchez,Maria Del Rosario I Amado,Helena Maruenda. (2008-06-19) The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors.. Bioorganic & medicinal chemistry, 16 ((14)): (6689-6695). [PMID:18558492] |
| 16. Taufiq Rahman,Mohammed Rahmatullah. (2009-12-09) Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases.. Bioorganic & medicinal chemistry letters, 20 ((2)): (537-540). [PMID:19969454] |
| 17. Jiawang Liu,Xueyun Jiang,Ming Zhao,Xiaoyi Zhang,Meiqing Zheng,Li Peng,Shiqi Peng. (2010-03-25) A class of 3S-2-aminoacyltetrahydro-beta-carboline-3-carboxylic acids: their facile synthesis, inhibition for platelet activation, and high in vivo anti-thrombotic potency.. Journal of medicinal chemistry, 53 ((8)): (3106-3116). [PMID:20329729] |
| 18. Shinya Oishi,Toshiaki Watanabe,Jun-Ichi Sawada,Akira Asai,Hiroaki Ohno,Nobutaka Fujii. (2010-06-05) Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds.. Journal of medicinal chemistry, 53 ((13)): (5054-5058). [PMID:20521839] |
| 19. Elan D Louis,Wendy Jiang,Marina Gerbin,Amanda S Viner,Pam Factor-Litvak,Wei Zheng. (2012-07-05) Blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor: repeat observation in cases and controls in New York.. Journal of toxicology and environmental health. Part A, 75 ((12)): (673-683). [PMID:22757671] |
| 20. Mohammad Hossein Esmaeili,Mohadeseh Movahedi,Ayda Faraji,Hashem Haghdoost-Yazdi. (2012-07-14) Intracerebral injection of low amounts of norharman induces moderate Parkinsonism-like behavioral symptoms in rat.. Neurotoxicology and teratology, 34 ((5)): (489-494). [PMID:22789434] |
| 21. Sabiha Abekhoukh,Chris Planque,Clémentine Ripoll,Paulina Urbaniak,Jean-Louis Paul,Jean-Maurice Delabar,Nathalie Janel. (2012-08-28) Dyrk1A, a serine/threonine kinase, is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice.. Molecular neurobiology, 47 ((1)): (105-116). [PMID:22923366] |
| 22. Elan D Louis,Julian Benito-León,Sara Moreno-García,Saturio Vega,Juan. (2012-09-18) Blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentration in essential tremor cases in Spain.. Neurotoxicology, 34 (): (264-268). [PMID:22981972] |
| 23. Mohammad Nasehi,Morteza Piri,Mojgan Abdollahian,Mohammad Reza Zarrindast. (2012-10-30) Involvement of nitrergic system of CA1in harmane induced learning and memory deficits.. Physiology & behavior, 109 (): (23-32). [PMID:23103833] |
| 24. Ipek Komsuoglu Celikyurt,Tijen Utkan,Semil Selcen Gocmez,Alan Hudson,Feyza Aricioglu. (2012-10-31) Effect of harmane, an endogenous β-carboline, on learning and memory in rats.. Pharmacology, biochemistry, and behavior, 103 ((3)): (666-671). [PMID:23107644] |
| 25. Ting Zhao,Shan-Song Zheng,Bin-Feng Zhang,Yuan-Yuan Li,S W Annie Bligh,Chang-Hong Wang,Zheng-Tao Wang. (2012-10-31) Metabolic pathways of the psychotropic-carboline alkaloids, harmaline and harmine, by liquid chromatography/mass spectrometry and NMR spectroscopy.. Food chemistry, 134 ((2)): (1096-1105). [PMID:23107733] |
| 26. Emilio Satoshi Hara,Mitsuaki Ono,Satoshi Kubota,Wataru Sonoyama,Yasutaka Oida,Takako Hattori,Takashi Nishida,Takayuki Furumatsu,Toshifumi Ozaki,Masaharu Takigawa,Takuo Kuboki. (2012-11-03) Novel chondrogenic and chondroprotective effects of the natural compound harmine.. Biochimie, 95 ((2)): (374-381). [PMID:23116713] |
| 27. Rihui Cao,Wenxi Fan,Liang Guo,Qin Ma,Guoxian Zhang,Jianru Li,Xuemei Chen,Zhenghua Ren,Liqin Qiu. (2013-01-08) Synthesis and structure-activity relationships of harmine derivatives as potential antitumor agents.. European journal of medicinal chemistry, 60 (): (135-143). [PMID:23291116] |
| 28. Giorgio Cozza,Stefania Sarno,Maria Ruzzene,Cristina Girardi,Andrzej Orzeszko,Zygmunt Kazimierczuk,Giuseppe Zagotto,Emanuela Bonaiuto,Maria Luisa Di Paolo,Lorenzo A Pinna. (2013-01-31) Exploiting the repertoire of CK2 inhibitors to target DYRK and PIM kinases.. Biochimica et biophysica acta, 1834 ((7)): (1402-1409). [PMID:23360763] |
| 29. Hua Shao,Xiaoli Huang,Yuanming Zhang,Chi Zhang. (2013-03-01) Main alkaloids of Peganum harmala L. and their different effects on dicot and monocot crops.. Molecules (Basel, Switzerland), 18 ((3)): (2623-2634). [PMID:23446919] |
| 30. Michael F Santillo,Yitong Liu,Martine Ferguson,Sanah N Vohra,Paddy L Wiesenfeld. (2014-01-01) Inhibition of monoamine oxidase (MAO) by β-carbolines and their interactions in live neuronal (PC12) and liver (HuH-7 and MH1C1) cells.. Toxicology in vitro : an international journal published in association with BIBRA, 28 ((3)): (403-410). [PMID:24373881] |
| 31. S M Biradar,Hanumanthachar Joshi,K C Tarak. (2014-02-11) Cerebroprotective effect of isolated harmine alkaloids extracts of seeds of Peganum harmala L. on sodium nitrite-induced hypoxia and ethanol-induced neurodegeneration in young mice.. Pakistan journal of biological sciences : PJBS, 16 ((23)): (1687-1697). [PMID:24506035] |
| 32. Wei Liu,Yadi Yang,Xuemei Cheng,Can Gong,Shuping Li,Dandan He,Li Yang,Zhengtao Wang,Changhong Wang. (2014-03-19) Rapid and sensitive detection of the inhibitive activities of acetyl- and butyryl-cholinesterases inhibitors by UPLC-ESI-MS/MS.. Journal of pharmaceutical and biomedical analysis, 94 (): (215-220). [PMID:24631841] |
| 33. Marzanna Kurzawa,Anna Filipiak-Szok,Ewa K?odzińska,Edward Sz?yk. (2015-06-09) Determination of phytochemicals, antioxidant activity and total phenolic content in Andrographis paniculata using chromatographic methods.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 995-996 (): (101-106). [PMID:26050926] |
| 34. Rie Sonamoto,Isao Kii,Yuka Koike,Yuto Sumida,Tomoe Kato-Sumida,Yukiko Okuno,Takamitsu Hosoya,Masatoshi Hagiwara. (2015-08-04) Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ.. Scientific reports, 5 (): (12728-12728). [PMID:26234946] |
| 35. David J Wagner,Haichuan Duan,Alenka Chapron,Richard W Lee,Joanne Wang. (2016-12-16) Potent inhibition of human organic cation transporter 2 (hOCT2) by β-carboline alkaloids.. Xenobiotica; the fate of foreign compounds in biological systems, 47 ((12)): (1112-1120). [PMID:27977936] |
| 36. Mohammad-Taghi Moradi,Ali Karimi,Mahmoud Rafieian-Kopaei,Fatemeh Fotouhi. (2017-06-21) In\xa0vitro antiviral effects of Peganum harmala seed extract and its total alkaloids against Influenza virus.. Microbial pathogenesis, 110 (): (42-49). [PMID:28629724] |
| 37. Ben K Ehe,David R Lamson,Michael Tarpley,Rob U Onyenwoke,Lee M Graves,Kevin P Williams. (2017-07-25) Identification of a DYRK1A-mediated phosphorylation site within the nuclear localization sequence of the hedgehog transcription factor GLI1.. Biochemical and biophysical research communications, 491 ((3)): (767-772). [PMID:28735864] |
| 38. Federico A O Rasse-Suriani,Fernando S García-Einschlag,Matías Rafti,Tobías Schmidt De León,Pedro M David Gara,Rosa Erra-Balsells,Franco M Cabrerizo. (2017-07-26) Photophysical and Photochemical Properties of Naturally Occurring normelinonine F and Melinonine F Alkaloids and Structurally Related N(2)- and/or N(9)-methyl-β-carboline Derivatives.. Photochemistry and photobiology, 94 ((1)): (36-51). [PMID:28741707] |
| 39. Shuping Li,Yunpeng Zhang,Gang Deng,Yuwen Wang,Shenglan Qi,Xuemei Cheng,Yueming Ma,Yan Xie,Changhong Wang. (2017-09-06) Exposure Characteristics of the Analogous β-Carboline Alkaloids Harmaline and Harmine Based on the Efflux Transporter of Multidrug Resistance Protein 2.. Frontiers in pharmacology, 8 (): (541-541). [PMID:28871225] |
| 40. Saqlain Haider,Manal Alhusban,Narayan D Chaurasiya,Babu L Tekwani,Amar G Chittiboyina,Ikhlas A Khan. (2018-05-24) Isoform selectivity of harmine-conjugated 1,2,3-triazoles against human monoamine oxidase.. Future medicinal chemistry, 10 ((12)): (1435-1448). [PMID:29788780] |
| 41. M V Uthaug,K van Oorsouw,K P C Kuypers,M van Boxtel,N J Broers,N L Mason,S W Toennes,J Riba,J G Ramaekers. (2018-08-15) Sub-acute and long-term effects of ayahuasca on affect and cognitive thinking style and their association with ego dissolution.. Psychopharmacology, 235 ((10)): (2979-2989). [PMID:30105399] |
| 42. Gaofeng Cui,Benshui Shu,Sethuraman Veeran,Haiqi Yuan,Xin Yi,Guohua Zhong. (2019-02-16) Natural β-carboline alkaloids regulate the PI3K/Akt/mTOR pathway and induce autophagy in insect Sf9 cells.. Pesticide biochemistry and physiology, 154 (): (67-77). [PMID:30765058] |
| 43. Yuxiang Zheng,Shivan Ramsamooj,Qian Li,Jared L Johnson,Tomer M Yaron,Klaus Sharra,Lewis C Cantley. (2019-03-14) Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase.. Scientific reports, 9 ((1)): (4190-4190). [PMID:30862944] |
| 44. Oliver Kluth,Mandy Stadion,Pascal Gottmann,Heja Aga,Markus J?hnert,Stephan Scherneck,Heike Vogel,Ulrika Krus,Anett Seelig,Charlotte Ling,Jantje Gerdes,Annette Schürmann. (2019-03-14) Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans.. Cell reports, 26 ((11)): (3027-3036). [PMID:30865891] |
| 45. Cui-Zan Cai,He-Feng Zhou,Ning-Ning Yuan,Ming-Yue Wu,Simon Ming-Yuen Lee,Jiao-Yan Ren,Huan-Xing Su,Jin-Jian Lu,Xiu-Ping Chen,Min Li,Jie-Qiong Tan,Jia-Hong Lu. (2019-05-03) Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 61 (): (152842-152842). [PMID:31048127] |
| 46. Simone Granno,Jonathon Nixon-Abell,Daniel C Berwick,Justin Tosh,George Heaton,Sultan Almudimeegh,Zenisha Nagda,Jean-Christophe Rain,Manuela Zanda,Vincent Plagnol,Victor L J Tybulewicz,Karen Cleverley,Frances K Wiseman,Elizabeth M C Fisher,Kirsten Harvey. (2019-05-16) Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus.. Scientific reports, 9 ((1)): (7322-7322). [PMID:31086297] |
| 47. Ivana Perkovi?, Silvana Rai?-Mali?, Diana Fontinha, Miguel Prudêncio, Lais Pessanha de Carvalho, Jana Held, Tana Tandari?, Robert Vianello, Branka Zorc, Zrinka Raji?,. (2019-12-08) Harmicines\xa0- harmine and cinnamic acid hybrids as novel antiplasmodial hits.. European journal of medicinal chemistry, (): ( 111927-111927 ). [PMID:31812035] |
| 48. Courtney Ackeifi,Ethan Swartz,Kunal Kumar,Hongtao Liu,Suebsuwong Chalada,Esra Karakose,Donald K Scott,Adolfo Garcia-Oca?a,Roberto Sanchez,Robert J DeVita,Andrew F Stewart,Peng Wang. (2019-12-11) Pharmacologic and genetic approaches define human pancreatic β cell mitogenic targets of DYRK1A inhibitors.. JCI insight, 5 ((1)): (). [PMID:31821176] |
| 49. Edwin A Rosado-Olivieri,Idil I Aigha,Jennifer H Kenty,Douglas A Melton. (2020-01-14) Identification of a LIF-Responsive, Replication-Competent Subpopulation of Human β Cells.. Cell metabolism, 31 ((2)): (327-338). [PMID:31928884] |
| 50. Dea Shahinas,Michael Liang,Alessandro Datti,Dylan R Pillai. (2010-03-31) A repurposing strategy identifies novel synergistic inhibitors of Plasmodium falciparum heat shock protein 90.. Journal of medicinal chemistry, 53 ((9)): (3552-3557). [PMID:20349996] |
| 51. J Reniers,S Robert,R Frederick,B Masereel,S Vincent,J Wouters. (2010-12-25) Synthesis and evaluation of β-carboline derivatives as potential monoamine oxidase inhibitors.. Bioorganic & medicinal chemistry, 19 ((1)): (134-144). [PMID:21183355] |
| 52. Daniel I Brierley,Colin Davidson. (2012-06-14) Developments in harmine pharmacology--implications for ayahuasca use and drug-dependence treatment.. Progress in neuro-psychopharmacology & biological psychiatry, 39 ((2)): (263-272). [PMID:22691716] |
| 53. Rapha?l Frédérick,Céline Bruyère,Christelle Vancraeynest,Jérémy Reniers,Céline Meinguet,Lionel Pochet,Anders Backlund,Bernard Masereel,Robert Kiss,Johan Wouters. (2012-07-10) Novel trisubstituted harmine derivatives with original in vitro anticancer activity.. Journal of medicinal chemistry, 55 ((14)): (6489-6501). [PMID:22770529] |
| 54. Suzan Owaisat,Robert B Raffa,Scott M Rawls. (2012-08-11) In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism.. Neuroscience letters, 525 ((1)): (12-16). [PMID:22877698] |
| 55. Bernd Blobel. (2012-08-29) Security and privacy services in pathology for enabling trustworthy personal health.. Studies in health technology and informatics, 179 (): (203-217). [PMID:22925800] |
| 56. Fujun Dai,Yihua Chen,Yajuan Song,Li Huang,Dong Zhai,Yanmin Dong,Li Lai,Tao Zhang,Dali Li,Xiufeng Pang,Mingyao Liu,Zhengfang Yi. (2013-01-10) A natural small molecule harmine inhibits angiogenesis and suppresses tumour growth through activation of p53 in endothelial cells.. PloS one, 7 ((12)): (e52162-e52162). [PMID:23300602] |
| 57. Akihisa Abe,Hiroko Kokuba. (2013-01-23) Harmol induces autophagy and subsequent apoptosis in U251MG human glioma cells through the downregulation of survivin.. Oncology reports, 29 ((4)): (1333-1342). [PMID:23338618] |
| 58. Huailei Liu,Dayong Han,Yaohua Liu,Xu Hou,Jianing Wu,Huadong Li,Jie Yang,Chen Shen,Guang Yang,Changyu Fu,Xianfeng Li,Hui Che,Jing Ai,Shiguang Zhao. (2013-02-09) Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma.. Journal of neuro-oncology, 112 ((1)): (39-48). [PMID:23392846] |
| 59. Fatima Lamchouri,Mustapha Zemzami,Akino Jossang,Abdellatif Abdellatif,Zafar H Israili,Badiaa Lyoussi. (2013-07-03) Cytotoxicity of alkaloids isolated from Peganum harmala seeds.. Pakistan journal of pharmaceutical sciences, 26 ((4)): (699-706). [PMID:23811445] |
| 60. Mohammad Nasehi,Elham Mashaghi,Fatemeh Khakpai,Mohammad-Reza Zarrindast. (2013-10-10) Suggesting a possible role of CA1 histaminergic system in harmane-induced amnesia.. Neuroscience letters, 556 (): (5-9). [PMID:24103378] |
| 61. Makio Saeki,Hiroshi Egusa. (2014-12-11) [Novel strategies for the development of anabolic agents for treatment of osteoporosis].. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 144 ((6)): (277-280). [PMID:25492363] |
| 62. Marcos Tascon,Fernando Benavente,Victoria M Sanz-Nebot,Leonardo G Gagliardi. (2015-03-10) Fast determination of harmala alkaloids in edible algae by capillary electrophoresis mass spectrometry.. Analytical and bioanalytical chemistry, 407 ((13)): (3637-3645). [PMID:25749794] |
| 63. Aline Pic-Taylor,Luciana Gueiros da Motta,Juliana Alves de Morais,Willian Melo Junior,Alana de Fátima Andrade Santos,Leandro Ambrósio Campos,Marcia Renata Mortari,Marcus Vinicius von Zuben,Eloisa Dutra Caldas. (2015-06-07) Behavioural and neurotoxic effects of ayahuasca infusion (Banisteriopsis caapi and Psychotria viridis) in female Wistar rat.. Behavioural processes, 118 (): (102-110). [PMID:26049017] |
| 64. Xiaofei Shang,Xiao Guo,Bing Li,Hu Pan,Jiyu Zhang,Yu Zhang,Xiaolou Miao. (2016-07-28) Microwave-assisted extraction of three bioactive alkaloids from Peganum harmala L. and their acaricidal activity against Psoroptes cuniculi in vitro.. Journal of ethnopharmacology, 192 (): (350-361). [PMID:27452655] |
| 65. Luis G Rabaneda,Noelia Geribaldi-Doldán,Maribel Murillo-Carretero,Manuel Carrasco,José M Martínez-Salas,Cristina Verástegui,Carmen Castro. (2016-11-05) Altered regulation of the Spry2/Dyrk1A/PP2A triad by homocysteine impairs neural progenitor cell proliferation.. Biochimica et biophysica acta, 1863 ((12)): (3015-3026). [PMID:27686255] |
| 66. Jose A Morales-García,Mario de la Fuente Revenga,Sandra Alonso-Gil,María Isabel Rodríguez-Franco,Amanda Feilding,Ana Perez-Castillo,Jordi Riba. (2017-07-15) The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro.. Scientific reports, 7 ((1)): (5309-5309). [PMID:28706205] |
| 67. Jin-Hyung Lee,Yong-Guy Kim,Sang Hee Shim,Jintae Lee. (2017-11-22) Antibiofilm activities of norharmane and its derivatives against Escherichia coli O157:H7 and other bacteria.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 36 (): (254-261). [PMID:29157822] |
| 68. Hedwig S Kruitwagen,Bart Westendorp,Cornelia S Viebahn,Krista Post,Monique E van Wolferen,Loes A Oosterhoff,David A Egan,Jean-Maurice Delabar,Mathilda J Toussaint,Baukje A Schotanus,Alain de Bruin,Jan Rothuizen,Louis C Penning,Bart Spee. (2017-11-29) DYRK1A Is a Regulator of S-Phase Entry in Hepatic Progenitor Cells.. Stem cells and development, 27 ((2)): (133-146). [PMID:29179659] |
| 69. Yue Wei,Tingyun Ma,Hanxue Wang,Jianguo Xing,Yuwen Wang,Zhengyi Gu,Dandan Mu,Qiang Yin,Xuemei Cheng,Changhong Wang. (2018-05-22) Extracts of compound Muniziqi granule suppressed uterus contraction and ameliorated oxytocin-induced primary dysmenorrhea.. Journal of ethnopharmacology, 223 (): (33-40). [PMID:29783015] |
| 70. Simon Uzor,Panagiota Zorzou,Elizabeth Bowler,Sean Porazinski,Ian Wilson,Michael Ladomery. (2018-05-29) Autoregulation of the human splice factor kinase CLK1 through exon skipping and intron retention.. Gene, 670 (): (46-54). [PMID:29802995] |
| 71. Katie L Uhl,Chad R Schultz,Dirk Geerts,André S Bachmann. (2018-07-07) Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma.. Cancer cell international, 18 (): (82-82). [PMID:29977157] |
| 72. Vikalp Vishwakarma,Jacob New,Dhruv Kumar,Vusala Snyder,Levi Arnold,Emily Nissen,Qingting Hu,Nikki Cheng,David Miller,Ahia Rael Thomas,Yelizaveta Shnayder,Kiran Kakarala,Terance Ted Tsue,Douglas A Girod,Sufi Mary Thomas. (2018-08-17) Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds.. Scientific reports, 8 ((1)): (12163-12163). [PMID:30111862] |
| 73. Xiumei Wei,Huiying Li,Yu Zhang,Cheng Li,Kang Li,Kete Ai,Jialong Yang. (2019-12-25) Ca2+-Calcineurin Axis-Controlled NFAT Nuclear Translocation Is Crucial for Optimal T Cell Immunity in an Early Vertebrate.. Journal of immunology (Baltimore, Md. : 1950), 204 ((3)): (569-585). [PMID:31871019] |
| 74. L Trovò,C Fuchs,R De Rosa,I Barbiero,M Tramarin,E Ciani,L Rusconi,C Kilstrup-Nielsen. (2020-02-08) The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo.. Neurobiology of disease, 138 (): (104791-104791). [PMID:32032735] |
| 75. Helen Rankin Willsey,Yuxiao Xu,Amanda Everitt,Jeanselle Dea,Cameron R T Exner,A Jeremy Willsey,Matthew W State,Richard M Harland. (2020-05-30) The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos.. Development (Cambridge, England), 147 ((21)): (). [PMID:32467234] |
| 76. Saghar Pahlavanneshan,Mehrdad Behmanesh,Daniel Oropeza,Kenichiro Furuyama,Yaser Tahamtani,Mohsen Basiri,Pedro L Herrera,Hossein Baharvand. (2020-07-11) Combined inhibition of menin-MLL interaction and TGF-β signaling induces replication of human pancreatic beta cells.. European journal of cell biology, 99 ((5)): (151094-151094). [PMID:32646642] |
首页
400-620-6333
危险品化学品经营许可证（带存储）