Cas(119418-04-1), 甘丙肽,人-阿拉丁试剂, ,Galanin, human,

货号 (SKU)	包装规格	是否现货	价格	数量
G118937-1mg	1mg	现货
G118937-5mg	5mg	现货

基本描述

规格或纯度	≥97% (HPLC)
英文名称	Galanin, human
生化机理	Co-localized with acetylcholine and inhibits its release; inhibits the release of glutamic acid, decreases excitability of spinal neurons; blocks voltage-activated Ca2+ channels; linked to behavioral and cognitive deficits in Alzheimer′s disease.
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	1mg卖完停产，不再备货
产品介绍	氨基酸序列 Gly-Trp-Thr-Leu-Asn-Ser-A?la-Gly-Tyr-Leu-Leu-Gly-Pr?o-His-Ala-Val-Gly-Asn-His?-Arg-Ser-Phe-Ser-Asp-Lys-?Asn-Gly-Leu-Thr-Ser Amino Acid Sequence Gly-Trp-Thr-Leu-Asn-Ser-A?la-Gly-Tyr-Leu-Leu-Gly-Pr?o-His-Ala-Val-Gly-Asn-His?-Arg-Ser-Phe-Ser-Asp-Lys-?Asn-Gly-Leu-Thr-Ser

名称和标识符

IUPAC Name	(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]acetyl]amino]-4-oxobutanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-4-[[(2S)-6-amino-1-[[(2S)-4-amino-1-[[2-[[(2S)-1-[[(2S,3R)-1-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-oxobutanoic acid
INCHI	InChI=1S/C139H210N42O43/c1-65(2)38-84(165-121(206)86(40-67(5)6)166-123(208)88(43-75-31-33-79(188)34-32-75)161-106(193)55-151-114(199)70(11)157-131(216)97(59-182)175-127(212)95(49-104(144)191)170-122(207)87(41-68(7)8)173-136(221)112(72(13)186)180-130(215)90(159-105(192)51-141)44-76-52-150-81-27-19-18-26-80(76)81)116(201)154-58-109(196)181-37-23-30-101(181)134(219)172-91(45-77-53-147-63-155-77)120(205)158-71(12)115(200)178-111(69(9)10)135(220)153-57-108(195)162-94(48-103(143)190)126(211)168-92(46-78-54-148-64-156-78)125(210)164-83(29-22-36-149-139(145)146)119(204)174-98(60-183)132(217)167-89(42-74-24-16-15-17-25-74)124(209)176-99(61-184)133(218)171-96(50-110(197)198)128(213)163-82(28-20-21-35-140)118(203)169-93(47-102(142)189)117(202)152-56-107(194)160-85(39-66(3)4)129(214)179-113(73(14)187)137(222)177-100(62-185)138(223)224/h15-19,24-27,31-34,52-54,63-73,82-101,111-113,150,182-188H,20-23,28-30,35-51,55-62,140-141H2,1-14H3,(H2,142,189)(H2,143,190)(H2,144,191)(H,147,155)(H,148,156)(H,151,199)(H,152,202)(H,153,220)(H,154,201)(H,157,216)(H,158,205)(H,159,192)(H,160,194)(H,161,193)(H,162,195)(H,163,213)(H,164,210)(H,165,206)(H,166,208)(H,167,217)(H,168,211)(H,169,203)(H,170,207)(H,171,218)(H,172,219)(H,173,221)(H,174,204)(H,175,212)(H,176,209)(H,177,222)(H,178,200)(H,179,214)(H,180,215)(H,197,198)(H,223,224)(H4,145,146,149)/t70-,71-,72+,73+,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,111-,112-,113-/m0/s1
InChi Key	CBSXZYWGVAQSHI-RUKUCZSXSA-N
Canonical SMILES	CC(C)CC(C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)O)NC(=O)CNC(=O)C(CC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC2=CNC=N2)NC(=O)C(CC(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CC3=CNC=N3)NC(=O)C4CCCN4C(=O)CNC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)CNC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(C(C)O)NC(=O)C(CC6=CNC7=CC=CC=C76)NC(=O)CN
分子式	C₁₃₉H₂₁₀N₄₂O₄₃
PubChem CID	16133823
分子量	3157.41

靶标

Target ID

243

名称

GAL₁ receptor

缩写名

SHP2

家族

Galanin receptors

别名

α_1b

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	346	18q12.3	Galr1	galanin receptor 1
Human	7	349	18q23	GALR1	galanin receptor 1
Mouse	7	348	18 55.78 cM	Galr1	galanin receptor 1

RefSeq Protein

NP_037090 (Rn) , NP_001471 (Hs) , NP_032108 (Mm)

UniProtKB

Q62805 (Rn) , P47211 (Hs) , P56479 (Mm)

OMIM

600377 (Hs)

RefSeq Nucleotide

NM_001480 (Hs) , NM_012958 (Rn) , NM_008082 (Mm)

Entrez Gene

2587 (Hs) , 50577 (Rn) , 14427 (Mm)

Ensembl Gene

ENSG00000166573 (Hs) , ENSMUSG00000024553 (Mm) , ENSRNOG00000016654 (Rn)

Protein GI

164518935 (Rn) , 6679933 (Mm) , 167000885 (Hs)

dbSNP

rs2717162 (Hs) , rs9959924 (Hs) , rs2717164 (Hs)

GPCRdb

galr1_human (Hs) , galr1_mouse (Mm) , galr1_rat (Rn)

UniProtKB ID/Entry name

GALR1_HUMAN (Hs) , GALR1_MOUSE (Mm) , GALR1_RAT (Rn)

ChEMBL Target

CHEMBL4894 (Hs) , CHEMBL5504 (Rn)

Target ID

244

名称

GAL₂ receptor

缩写名

SHP2

家族

Galanin receptors

别名

α_1b

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	372	10q32.1	Galr2	galanin receptor 2
Human	7	387	17q25.1	GALR2	galanin receptor 2
Mouse	7	371	11 81.1 cM	Galr2	galanin receptor 2

RefSeq Protein

NP_062045 (Rn) , NP_003848 (Hs) , NP_034384 (Mm)

UniProtKB

O08726 (Rn) , O43603 (Hs) , O88854 (Mm)

OMIM

603691 (Hs)

RefSeq Nucleotide

NM_003857 (Hs) , NM_019172 (Rn) , NM_010254 (Mm)

Entrez Gene

8811 (Hs) , 29234 (Rn) , 14428 (Mm)

Ensembl Gene

ENSG00000182687 (Hs) , ENSMUSG00000020793 (Mm) , ENSRNOG00000061733 (Rn)

Protein GI

161353471 (Mm) , 9506709 (Rn) , 4503905 (Hs)

GPCRdb

galr2_human (Hs) , galr2_mouse (Mm) , galr2_rat (Rn)

UniProtKB ID/Entry name

GALR2_HUMAN (Hs) , GALR2_MOUSE (Mm) , GALR2_RAT (Rn)

ChEMBL Target

CHEMBL5577 (Rn) , CHEMBL3176 (Hs)

Target ID

245

名称

GAL₃ receptor

缩写名

SHP2

家族

Galanin receptors

别名

α_1b

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	370	7q34	Galr3	galanin receptor 3
Human	7	368	22q13.1	GALR3	galanin receptor 3
Mouse	7	370	15 37.7 cM	Galr3	galanin receptor 3

RefSeq Protein

NP_062046 (Rn) , NP_003605 (Hs) , NP_056553 (Mm)

UniProtKB

O88626 (Rn) , O60755 (Hs) , O88853 (Mm)

OMIM

603692 (Hs)

RefSeq Nucleotide

NM_003614 (Hs) , NM_019173 (Rn) , NM_015738 (Mm)

Entrez Gene

8484 (Hs) , 29235 (Rn) , 14429 (Mm)

Ensembl Gene

ENSG00000128310 (Hs) , ENSRNOG00000027060 (Rn) , ENSMUSG00000114755 (Mm)

Protein GI

9506711 (Rn) , 226530468 (Mm) , 4503907 (Hs)

dbSNP

rs3091367 (Hs)

GPCRdb

galr3_human (Hs) , galr3_mouse (Mm) , galr3_rat (Rn)

UniProtKB ID/Entry name

GALR3_HUMAN (Hs) , GALR3_MOUSE (Mm) , GALR3_RAT (Rn)

ChEMBL Target

CHEMBL2731 (Hs)

关联配体

Ligand ID

3592

名称

galanin

类别

Peptide

学名

4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide

生物活性评价

The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).

评价

Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth.

配体家族

Neuropeptides

基因/前体

Gene symbol	Gene name	Precursor protein name	Species	别名
GAL	galanin and GMAP prepropeptide	prepro-galanin	Human	GALN, GMAP, GLNN, galanin, galanin-message-associated peptide, galanin prepropeptide, galanin/GMAP prepropeptide

单字母多肽序列

GWTLNSAGYLLGPHAVGNHRSFSDKNGLTS

三字母多肽序列

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr-Ser

翻译后修饰

None

化学修饰

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甘丙肽,人

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甘丙肽,人

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