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基本描述
| 英文名称 | evocalcet |
|---|---|
| 别名 | KHK-7580;MT-4580 |
| 英文别名 | KHK-7580;MT-4580 |
名称和标识符
| IUPAC Name | 2-[4-[(3S)-3-[[(1R)-1-naphthalen-1-ylethyl]amino]pyrrolidin-1-yl]phenyl]acetic acid |
|---|---|
| INCHI | InChI=1S/C24H26N2O2/c1-17(22-8-4-6-19-5-2-3-7-23(19)22)25-20-13-14-26(16-20)21-11-9-18(10-12-21)15-24(27)28/h2-12,17,20,25H,13-16H2,1H3,(H,27,28)/t17-,20+/m1/s1 |
| InChi Key | RZNUIYPHQFXBAN-XLIONFOSSA-N |
| Canonical SMILES | CC(C1=CC=CC2=CC=CC=C21)NC3CCN(C3)C4=CC=C(C=C4)CC(=O)O |
| PubChem CID | 71242808 |
| 分子量 | 374.48 |
数据库链接
关联配体
| Ligand ID | 9042 |
|---|---|
| 名称 | evocalcet |
| 别名 | MT-4580 |
| 类别 | Synthetic organic |
| 学名 | 2-[4-[(3S)-3-[[(1R)-1-naphthalen-1-ylethyl]amino]pyrrolidin-1-yl]phenyl]acetic acid |
| 生物活性评价 |
Peer reviewed, freely accessible data supporting evolacet's molecular interaction with the CASR is not available. US8362274 only provides EC50 data for a few of the claimed compounds, but not for this specific example (3.008) |
| 评价 |
Evocalcet is an investigational calcium-sensing receptor (CASR) agonist, or calcimimetic. CASR is a G protein-coupled receptor. This compound is claimed in patent US8362274 |
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产品问答
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