首页
400-620-6333
(E,2S)-N-(3-bromophenyl)-N'-cyano-2-methyl-4-{5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}piperazine-1-carboximidamide
- CAS编号: 1116571-01-7
- 分子式: C20H21BrN8
- 分子量: 453.3
- PubChem编号: 44477445
有货
切换导航
搜索
基本描述
| 英文名称 | (E,2S)-N-(3-bromophenyl)-N'-cyano-2-methyl-4-{5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}piperazine-1-carboximidamide |
|---|---|
| 别名 | compound 14 |
| 英文别名 | compound 14 |
名称和标识符
| IUPAC Name | (2S)-N'-(3-bromophenyl)-N-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide |
|---|---|
| INCHI | InChI=1S/C20H21BrN8/c1-13-9-23-18-17(13)19(26-12-25-18)28-6-7-29(14(2)10-28)20(24-11-22)27-16-5-3-4-15(21)8-16/h3-5,8-9,12,14H,6-7,10H2,1-2H3,(H,24,27)(H,23,25,26)/t14-/m0/s1 |
| InChi Key | KSECQYDNQYAZMQ-AWEZNQCLSA-N |
| Canonical SMILES | CC1CN(CCN1C(=NC2=CC(=CC=C2)Br)NC#N)C3=NC=NC4=C3C(=CN4)C |
| PubChem CID | 44477445 |
| 分子量 | 453.3 |
数据库链接
| ChEMBL Ligand | CHEMBL570126 |
|---|---|
| PubChem CID | 44477445 |
| CAS Registry No. | 1116571-01-7 |
关联配体
| Ligand ID | 8151 |
|---|---|
| 名称 | compound 14 [PMID: 19831390] |
| 类别 | Synthetic organic |
| 学名 | (E,2S)-N-(3-bromophenyl)-N'-cyano-2-methyl-4-{5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}piperazine-1-carboximidamide |
| 生物活性评价 |
Compound 14 is equipotent for both LIMK isozymes, and is selective for LIMK1/2 compared to the Rho-associated protein kinases ROCK1 and -2 |
| 评价 |
Compound 14 is one of the analogues designed in the search for novel, biologically active LIM domain kinase 2 (LIMK2) inhibitors |
产品问答
产品问答
参考文献
| 1. Harrison BA, Whitlock NA, Voronkov MV, Almstead ZY, Gu KJ, Mabon R, Gardyan M, Hamman BD, Allen J, Gopinathan S et al.. (2009) Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma.. J Med Chem, 52 (21): (6515-8). [PMID:19831390] |
上海阿拉丁生化科技股份有限公司
? 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任
危险品化学品经营许可证（带存储）