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埃罗替尼

规格或纯度: ≥98%

CAS编号: 183321-74-6
分子式: C₂₂H₂₃N₃O₄
分子量: 393.44
EC号: 689-196-2
PubChem编号: 176870

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货号 (SKU)	包装规格	是否现货	价格	数量
E126633-100mg	100mg	现货
E126633-500mg	500mg	现货
E126633-1g	1g	现货
E126633-5g	5g	现货
E126633-25g	25g	现货

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epidermal growth factor receptor Inhibitor OATP2B1 Inhibitor

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基本描述

规格或纯度	≥98%
英文名称	Erlotinib
别名	R 1415\|埃罗替尼
英文别名	Erlotinib\|183321-74-6\|N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine\|Tarceva\|Erlotinib free base\|4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline\|4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-\|OSI-774\|erloti
生化机理	Erlotinib hydrochloride (trade name Tarceva;NSC 718781; OSI 744; R 1415 ) is a drμg used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. Erlotinib hydrochloride (trade name Tarceva;NSC 718781; OSI 744; R 1415 ) is a reversible tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR). It is marketed in the United States by Genentech and OSI Pharmaceuticals and elsewhere by Roche.
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Erlotinib, Free Base, is the free base form of erlotinib hydrochloride (sc-202154), a small molecule EGFR/HER-1 (human epidermal growth factor receptor) tyrosine kinase reversible inhibitor.A tyrosine kinase inhibitor Erlotinib, Free Base, is the free base form of erlotinib hydrochloride (sc-202154), a small molecule EGFR/HER-1 (human epidermal growth factor receptor) tyrosine kinase reversible inhibitor. A tyrosine kinase inhibitor

名称和标识符

EC号	689-196-2
IUPAC Name	N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
INCHI	InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)
InChi Key	AAKJLRGGTJKAMG-UHFFFAOYSA-N
Canonical SMILES	COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC
关联CAS	183321-74-6
PubChem CID	176870
MeSH Entry Terms	11C erlotinib;11C-erlotinib;358,774, CP;358774, CP;CP 358,774;CP 358774;CP-358,774;CP-358774;CP358,774;CP358774;erlotinib;erlotinib HCl;erlotinib hydrochloride;HCl, Erlotinib;Hydrochloride, Erlotinib;N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-
分子量	393.44

数据库链接

DrugBank Ligand	DB00530
Wikipedia	Erlotinib
ChEBI	CHEBI:114785
CAS Registry No.	183321-74-6
DiscoveRx TREEspot	Erlotinib\|
ChEMBL Ligand	CHEMBL553
PubChem CID	176870
RCSB PDB Ligand	AQ4
PEP	erlotinib
Reactome Reaction	R-HSA-1220610
Reactome Drug	R-ALL-1173285
DrugCentral Ligand	1045

化学和物理性质

溶解性	DMSO
折光率	1.62
熔点	167-180°C

安全和危险性（GHS）

象形图	Health Hazard Environmental Hazard Harmful
信号词	Warning
危险声明	H351: Suspected of causing cancer H411: Toxic to aquatic life with long lasting effects H413: May cause long lasting harmful effects to aquatic life H302: Harmful if swallowed
预防措施声明	P273,P280,P405,P501,P264,P270,P391,P330,P203,P301+P317,P318

关联配体

Ligand ID	4920
名称	erlotinib
别名	NSC 718781
类别	Synthetic organic
学名	N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Erlotinib is a clinically approved type-1 inhibitor of the epidermal growth factor receptor (EGFR) receptor tyrosine kinase. This drug shows some selectivity for EGFR exon 19 deletion or exon 21 L858R mutations over the wild type receptor. Subsequent studies have shown erlotinib to be a potent inhibitor of JAK2V617F activity. JAK2V617F, a mutant from of tyrosine kinase JAK2, is found in most patients with polycythemia vera (PV) and a substantial proportion of patients with idiopathic myelofibrosis or essential thrombocythemia. Study suggests that erlotinib may be used for treatment of JAK2V617F-positive PV and other myeloproliferative disorders. Specificity of inhibition with regard to other tyrosine kinase receptors remains to be fully characterized. Erlotinib is a Type-1 kinase inhibitor.

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