β-内啡肽,人
- CAS编号: 61214-51-5
- 分子式: C158H251N39O46S
- 分子量: 3464.98
- MDL号: MFCD00076383
- PubChem编号: 16132316
库存信息
库存信息
库存信息
货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
---|---|---|---|---|
E118899-0.5mg | 0.5mg | 现货 | | |
E118899-1mg | 1mg | 现货 | | |
E118899-5mg | 5mg | 现货 | |
货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
---|---|---|---|---|
E118899-0.5mg | 0.5mg | 现货 | | |
E118899-1mg | 1mg | 现货 | | |
E118899-5mg | 5mg | 现货 | |
规格或纯度 | ≥96% (HPLC) |
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英文名称 | β-Endorphin, human |
别名 | β-Lipotropin 61-91 β-Lipotropin C-fragment LPH (61-91) |
英文别名 | β-Lipotropin 61-91 β-Lipotropin C-fragment LPH (61-91) |
生化机理 | Potent endogenous opioid protein that is derived from propiomelanocortin, a protein found in the brain, anterior pituitary, skin, immune system, and other peripheral sites. It is released in response to painful stimuli and has potent antinociceptive activity that is mediated throμgh its action on μ receptors in brain and by μ and κ receptors in the spinal cord. |
储存温度 | -20°C储存 |
运输条件 | 超低温冰袋运输 |
备注 | 卖完停产,不再备货 |
产品介绍 |
氨基酸序列 Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu Amino Acid Sequence Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu |
IUPAC Name | (2S)-2-[[2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]-4-oxobutanoyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-4-oxobutanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]hexanoyl]amino]hexanoyl]amino]acetyl]amino]pentanedioic acid |
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INCHI | InChI=1S/C158H251N39O46S/c1-17-84(9)126(153(237)182-102(44-29-34-65-163)137(221)186-112(74-118(166)206)142(226)171-86(11)131(215)183-110(73-94-48-52-96(204)53-49-94)146(230)177-99(41-26-31-62-160)135(219)175-98(40-25-30-61-159)134(218)170-78-122(210)173-106(158(242)243)56-59-124(213)214)193-154(238)127(85(10)18-2)192-132(216)87(12)172-143(227)113(75-119(167)207)185-136(220)100(42-27-32-63-161)178-147(231)111(72-92-38-23-20-24-39-92)184-144(228)107(68-81(3)4)188-155(239)129(89(14)201)195-152(236)125(83(7)8)191-148(232)108(69-82(5)6)187-151(235)116-45-35-66-197(116)157(241)130(90(15)202)196-140(224)103(54-57-117(165)205)179-149(233)114(79-198)189-138(222)101(43-28-33-64-162)176-139(223)104(55-58-123(211)212)180-150(234)115(80-199)190-156(240)128(88(13)200)194-141(225)105(60-67-244-16)181-145(229)109(71-91-36-21-19-22-37-91)174-121(209)77-168-120(208)76-169-133(217)97(164)70-93-46-50-95(203)51-47-93/h19-24,36-39,46-53,81-90,97-116,125-130,198-204H,17-18,25-35,40-45,54-80,159-164H2,1-16H3,(H2,165,205)(H2,166,206)(H2,167,207)(H,168,208)(H,169,217)(H,170,218)(H,171,226)(H,172,227)(H,173,210)(H,174,209)(H,175,219)(H,176,223)(H,177,230)(H,178,231)(H,179,233)(H,180,234)(H,181,229)(H,182,237)(H,183,215)(H,184,228)(H,185,220)(H,186,221)(H,187,235)(H,188,239)(H,189,222)(H,190,240)(H,191,232)(H,192,216)(H,193,238)(H,194,225)(H,195,236)(H,196,224)(H,211,212)(H,213,214)(H,242,243)/t84-,85-,86-,87-,88+,89+,90+,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,125-,126-,127-,128-,129-,130-/m0/s1 |
InChi Key | JMHFFDIMOUKDCZ-NTXHZHDSSA-N |
Canonical SMILES | CCC(C)C(C(=O)NC(C(C)CC)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(C)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)O)NC(=O)C(C)NC(=O)C(CC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(C(C)O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C3CCCN3C(=O)C(C(C)O)NC(=O)C(CCC(=O)N)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CCSC)NC(=O)C(CC4=CC=CC=C4)NC(=O)CNC(=O)CNC(=O)C(CC5=CC=C(C=C5)O)N |
分子式 |
C158H251N39O46S |
PubChem CID | 16132316 |
分子量 | 3464.98 |
Target ID | 317 | ||||||||||||||||||||||||
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名称 | δ receptor | ||||||||||||||||||||||||
缩写名 | SHP2 | ||||||||||||||||||||||||
家族 | Opioid receptors | ||||||||||||||||||||||||
别名 | NMB-R | ||||||||||||||||||||||||
基因和蛋白信息 |
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RefSeq Protein | NP_036749 (Rn) , NP_000902 (Hs) , NP_038650 (Mm) | ||||||||||||||||||||||||
UniProtKB | P33533 (Rn) , P41143 (Hs) , P32300 (Mm) | ||||||||||||||||||||||||
OMIM | 165195 (Hs) | ||||||||||||||||||||||||
RefSeq Nucleotide | NM_000911 (Hs) , NM_012617 (Rn) , NM_013622 (Mm) | ||||||||||||||||||||||||
Entrez Gene | 4985 (Hs) , 24613 (Rn) , 18386 (Mm) | ||||||||||||||||||||||||
Ensembl Gene | ENSG00000116329 (Hs) , ENSMUSG00000050511 (Mm) , ENSRNOG00000010531 (Rn) | ||||||||||||||||||||||||
Protein GI | 63477962 (Hs) , 6981308 (Rn) , 124244064 (Mm) | ||||||||||||||||||||||||
GPCRdb | oprd_human (Hs) , oprd_mouse (Mm) , oprd_rat (Rn) | ||||||||||||||||||||||||
UniProtKB ID/Entry name | OPRD_HUMAN (Hs) , OPRD_MOUSE (Mm) , OPRD_RAT (Rn) | ||||||||||||||||||||||||
DrugBank Target | P41143 (Hs) | ||||||||||||||||||||||||
ChEMBL Target | CHEMBL269 (Rn) , CHEMBL236 (Hs) , CHEMBL3222 (Mm) |
Target ID | 318 | ||||||||||||||||||||||||
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名称 | κ receptor | ||||||||||||||||||||||||
缩写名 | SHP2 | ||||||||||||||||||||||||
家族 | Opioid receptors | ||||||||||||||||||||||||
别名 | NMB-R | ||||||||||||||||||||||||
基因和蛋白信息 |
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RefSeq Protein | NP_058863 (Rn) , NP_000903 (Hs) , NP_035141 (Mm) | ||||||||||||||||||||||||
UniProtKB | P34975 (Rn) , P41145 (Hs) , P33534 (Mm) | ||||||||||||||||||||||||
OMIM | 165196 (Hs) | ||||||||||||||||||||||||
RefSeq Nucleotide | NM_000912 (Hs) , NM_017167 (Rn) , NM_011011 (Mm) | ||||||||||||||||||||||||
Entrez Gene | 4986 (Hs) , 29335 (Rn) , 18387 (Mm) | ||||||||||||||||||||||||
Ensembl Gene | ENSG00000082556 (Hs) , ENSMUSG00000025905 (Mm) , ENSRNOG00000007647 (Rn) | ||||||||||||||||||||||||
Protein GI | 324120905 (Mm) , 8393879 (Rn) , 39725940 (Hs) | ||||||||||||||||||||||||
GPCRdb | oprk_human (Hs) , oprk_mouse (Mm) , oprk_rat (Rn) | ||||||||||||||||||||||||
UniProtKB ID/Entry name | OPRK_HUMAN (Hs) , OPRK_MOUSE (Mm) , OPRK_RAT (Rn) | ||||||||||||||||||||||||
DrugBank Target | P41145 (Hs) | ||||||||||||||||||||||||
dbSNP | rs6010719 (Hs) , rs6010718 (Hs) | ||||||||||||||||||||||||
ChEMBL Target | CHEMBL4329 (Mm) , CHEMBL3614 (Rn) , CHEMBL237 (Hs) |
Target ID | 319 | ||||||||||||||||||||||||
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名称 | μ receptor | ||||||||||||||||||||||||
缩写名 | SHP2 | ||||||||||||||||||||||||
家族 | Opioid receptors | ||||||||||||||||||||||||
别名 | NMB-R | ||||||||||||||||||||||||
基因和蛋白信息 |
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RefSeq Protein | NP_037203 (Rn) , NP_000905 (Hs) , NP_001034741 (Mm) | ||||||||||||||||||||||||
UniProtKB | P33535 (Rn) , P35372 (Hs) , P42866 (Mm) | ||||||||||||||||||||||||
OMIM | 600018 (Hs) | ||||||||||||||||||||||||
RefSeq Nucleotide | NM_000914 (Hs) , NM_013071 (Rn) , NM_001039652 (Mm) | ||||||||||||||||||||||||
Entrez Gene | 4988 (Hs) , 25601 (Rn) , 18390 (Mm) | ||||||||||||||||||||||||
Ensembl Gene | ENSG00000112038 (Hs) , ENSMUSG00000000766 (Mm) , ENSRNOG00000018191 (Rn) | ||||||||||||||||||||||||
Protein GI | 89001114 (Mm) , 145553980 (Rn) , 223718719 (Hs) | ||||||||||||||||||||||||
GPCRdb | oprm_human (Hs) , oprm_mouse (Mm) , oprm_rat (Rn) | ||||||||||||||||||||||||
UniProtKB ID/Entry name | OPRM_HUMAN (Hs) , OPRM_MOUSE (Mm) , OPRM_RAT (Rn) | ||||||||||||||||||||||||
DrugBank Target | P35372 (Hs) | ||||||||||||||||||||||||
ChEMBL Target | CHEMBL2858 (Mm) , CHEMBL270 (Rn) , CHEMBL233 (Hs) |
Ligand ID | 1643 | ||||||||||
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名称 | β-endorphin | ||||||||||
别名 | β-end | ||||||||||
类别 | Peptide | ||||||||||
学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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评价 | Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth. | ||||||||||
配体家族 | Neuropeptides | ||||||||||
基因/前体 |
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单字母多肽序列 | YGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE | ||||||||||
三字母多肽序列 | Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu | ||||||||||
翻译后修饰 | |||||||||||
化学修饰 |