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1-[5-[6-(2,6-dimethyl-4-pentan-3-yloxyphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]-3-methylurea

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货号 (SKU) 包装规格 是否现货 价格 数量
D609099-5mg
 5mg 期货 Stock Image
D609099-25mg
 25mg 期货 Stock Image
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LIM domain kinase 1 Inhibitor LIM domain kinase 2 Inhibitor testis associated actin remodelling kinase 1 Inhibitor testis associated actin remodelling kinase 2 Inhibitor
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基本描述

英文名称 1-[5-[6-(2,6-dimethyl-4-pentan-3-yloxyphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]-3-methylurea
别名 compound 30
英文别名 compound 30

名称和标识符

IUPAC Name 1-[5-[6-(2,6-dimethyl-4-pentan-3-yloxyphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]-3-methylurea
INCHI InChI=1S/C26H29N7O2S/c1-6-17(7-2)35-18-10-15(3)23(16(4)11-18)20-12-19(22-14-30-26(36-22)33-25(34)27-5)31-24(32-20)21-13-28-8-9-29-21/h8-14,17H,6-7H2,1-5H3,(H2,27,30,33,34)
InChi Key RYXLLTGGHCFCFK-UHFFFAOYSA-N
Canonical SMILES CNC(=O)Nc1ncc(s1)c1nc(nc(c1)c1c(C)cc(cc1C)OC(CC)CC)c1nccnc1
PubChem CID 58688690

关联配体

Ligand ID 8118
名称 compound 30 [PMID: 22902653]
类别 Synthetic organic
学名 1-[5-[6-(2,6-dimethyl-4-pentan-3-yloxyphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]-3-methylurea
生物活性评价 The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价 Compound 30 was designed as an inhibitor of the LIM domain kinases LIMK1 and LIMK2

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参考文献

1. R?sok O, Pedeutour F, Ree AH, Aasheim HC.  (1999)  Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis..  Genomics,  61  (1):  (44-54).  [PMID:10512679]
2. Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K.  (2001)  Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells..  J Biol Chem,  276  (33):  (31449-58).  [PMID:11418599]
3. Johne C, Matenia D, Li XY, Timm T, Balusamy K, Mandelkow EM.  (2008)  Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton..  Mol Biol Cell,  19  (4):  (1391-403).  [PMID:18216281]
4. He L, Seitz SP, Trainor GL, Tortolani D, Vaccaro W, Poss M, Tarby CM, Tokarski JS, Penhallow B, Hung CY et al..  (2012)  Modulation of cofilin phosphorylation by inhibition of the Lim family kinases..  Bioorg Med Chem Lett,  22  (18):  (5995-8).  [PMID:22902653]
5. Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, Bernard O, Caroni P.  (1998)  Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase..  Nature,  393  (6687):  (805-9).  [PMID:9655397]
6. Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K.  (1998)  Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization..  Nature,  393  (6687):  (809-12).  [PMID:9655398]
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