Cas(16679-58-6), 醋酸去氨压素-阿拉丁试剂, 去氨加压素,Desmopressin Acetate,

货号 (SKU)	包装规格	是否现货
D123296-5mg	5mg	现货
D123296-25mg	25mg	现货
D123296-100mg	100mg	现货

基本描述

规格或纯度	≥97.0%(HPLC)
英文名称	[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate
别名	[去氨基-Cys1, D-Arg8]-加压素乙酸盐水合物
英文别名	DDAVP,Desmopressin
生化机理	Desmopressin acetate is the synthetic analogue of the antidiuretic hormone arginine vasopressin. The antidiuretic properties of desmopressin have led to its use in polyuric conditions including primary nocturnal enuresis, nocturia, and diabetes insipidus. Desmopressin works by limiting the amount of water that is eliminated in the urine. Desmopressin binds to V2 receptors in renal collecting ducts, increasing water reabsorption. It also stimulates release of von Willebrand factor from endothelial cells by acting on the V2 receptor.Vasopressin V2 receptor agonist. Has antidiuretic effects in vitro . A modified form of the normal human hormone arginine vasopressin.
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，这些产品最多可以使用一周。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	Mpa-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 [Disulfide Bridge: 1-6] Mpa-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 [Disulfide Bridge: 1-6]

名称和标识符

EC号	240-726-7
IUPAC Name	(2S)-N-[(2R)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
INCHI	InChI=1S/C46H64N14O12S2/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52)/t28-,29+,30+,31+,32+,33+,34+/m1/s1
InChi Key	NFLWUMRGJYTJIN-PNIOQBSNSA-N
Canonical SMILES	C1CC(N(C1)C(=O)C2CSSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N
分子式	C₄₆H₆₄N₁₄O₁₂S₂·xC₂H₄O₂·yH₂O
关联CAS	16679-58-6 (free base)
PubChem CID	5311065
分子量	1069.24

数据库链接

PubChem CID	27991
ChEBI	CHEBI:4450
DrugBank Ligand	DB00035
CAS Registry No.	16679-58-6
Wikipedia	Desmopressin
ChEMBL Ligand	CHEMBL264448
GPCRdb Ligand	desmopressin

化学和物理性质

溶解性	20 mg/mL in H2O

安全信息

象形图	Health Hazard Corrosive Harmful
信号词	Danger
危险声明	H314: Causes severe skin burns and eye damage H317: May cause an allergic skin reaction H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled H332: Harmful if inhaled
预防措施声明	P261,P280,P302+P352,P321,P405,P501,P264,P260,P284,P271,P301+P330+P331,P304+P340,P363,P272,P333+P313,P362+P364,P305+P354+P338,P317,P302+P361+P354,P316,P342+P316
WGK Germany	3
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

靶标

Target ID

366

名称

V_1A receptor

缩写名

SHP2

家族

Vasopressin and oxytocin receptors

别名

Peripheral cannabinoid receptor

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	424	7q22	Avpr1a	arginine vasopressin receptor 1A
Human	7	418	12q14.2	AVPR1A	arginine vasopressin receptor 1A
Mouse	7	423	10 D2	Avpr1a	arginine vasopressin receptor 1A

RefSeq Protein

NP_444178 (Rn) , NP_000697 (Hs) , NP_058543 (Mm)

UniProtKB

P30560 (Rn) , P37288 (Hs) , Q62463 (Mm)

OMIM

600821 (Hs)

RefSeq Nucleotide

NM_000706 (Hs) , NM_053019 (Rn) , NM_016847 (Mm)

Entrez Gene

552 (Hs) , 25107 (Rn) , 54140 (Mm)

Ensembl Gene

ENSG00000166148 (Hs) , ENSMUSG00000020123 (Mm) , ENSRNOG00000004400 (Rn)

Protein GI

33149329 (Mm) , 4502331 (Hs) , 33149327 (Rn)

GPCRdb

v1ar_human (Hs) , v1ar_mouse (Mm) , v1ar_rat (Rn)

UniProtKB ID/Entry name

V1AR_HUMAN (Hs) , V1AR_MOUSE (Mm) , V1AR_RAT (Rn)

DrugBank Target

P37288 (Hs)

ChEMBL Target

CHEMBL1889 (Hs) , CHEMBL2868 (Rn) , CHEMBL3414410 (Mm)

Target ID

367

名称

V_1B receptor

缩写名

SHP2

家族

Vasopressin and oxytocin receptors

别名

Peripheral cannabinoid receptor

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	425	13q13	Avpr1b	arginine vasopressin receptor 1B
Human	7	424	1q32.1	AVPR1B	arginine vasopressin receptor 1B
Mouse	7	421	1 E4	Avpr1b	arginine vasopressin receptor 1B

涉及到的疾病

Asthma , Chronic obstructive pulmonary disease

RefSeq Protein

NP_058901 (Rn) , NP_000698 (Hs) , NP_036054 (Mm)

UniProtKB

P48974 (Rn) , P47901 (Hs) , Q9WU02 (Mm)

OMIM

600264 (Hs)

RefSeq Nucleotide

NM_000707 (Hs) , NM_017205 (Rn) , NM_011924 (Mm)

Entrez Gene

553 (Hs) , 29462 (Rn) , 26361 (Mm)

Ensembl Gene

ENSG00000198049 (Hs) , ENSMUSG00000026432 (Mm)

Protein GI

77404390 (Rn) , 4502333 (Hs) , 6753152 (Mm)

GPCRdb

v1br_human (Hs) , v1br_mouse (Mm) , v1br_rat (Rn)

UniProtKB ID/Entry name

V1BR_HUMAN (Hs) , V1BR_MOUSE (Mm) , V1BR_RAT (Rn)

dbSNP

rs28632197 (Hs) , rs28536160 (Hs) , rs33990840 (Hs) , rs28373064 (Hs) , rs35369693 (Hs)

DrugBank Target

P47901 (Hs)

ChEMBL Target

CHEMBL1921 (Hs) , CHEMBL2659 (Rn)

Target ID

368

名称

V₂ receptor

缩写名

SHP2

家族

Vasopressin and oxytocin receptors

别名

Peripheral cannabinoid receptor

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	371	Xq37	Avpr2	arginine vasopressin receptor 2
Human	7	371	Xq28	AVPR2	arginine vasopressin receptor 2
Mouse	7	371	X 37.46 cM	Avpr2	arginine vasopressin receptor 2

RefSeq Protein

NP_062009 (Rn) , NP_000045 (Hs) , NP_062277 (Mm)

UniProtKB

Q00788 (Rn) , P30518 (Hs) , O88721 (Mm)

OMIM

304800 (Hs)

RefSeq Nucleotide

NM_000054 (Hs) , NM_019136 (Rn) , NM_019404 (Mm)

Entrez Gene

554 (Hs) , 25108 (Rn) , 12000 (Mm)

Ensembl Gene

ENSG00000126895 (Hs) , ENSMUSG00000031390 (Mm) , ENSRNOG00000059862 (Rn)

Orphanet

118947 (Hs)

Protein GI

9506415 (Rn) , 9506413 (Mm) , 225903385 (Hs)

GPCRdb

v2r_human (Hs) , v2r_mouse (Mm) , v2r_rat (Rn)

UniProtKB ID/Entry name

V2R_HUMAN (Hs) , V2R_MOUSE (Mm) , V2R_RAT (Rn)

DrugBank Target

P30518 (Hs)

ChEMBL Target

CHEMBL1790 (Hs) , CHEMBL3766 (Rn)

Target ID

369

名称

OT receptor

缩写名

SHP2

家族

Vasopressin and oxytocin receptors

别名

Peripheral cannabinoid receptor

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	388	4q41	Oxtr	oxytocin receptor
Human	7	389	3p25.3	OXTR	oxytocin receptor
Mouse	7	388	6 E3	Oxtr	oxytocin receptor

RefSeq Protein

NP_037003 (Rn) , NP_000907 (Hs) , NP_001074616 (Mm)

UniProtKB

P70536 (Rn) , P30559 (Hs) , P97926 (Mm)

OMIM

167055 (Hs)

RefSeq Nucleotide

NM_000916 (Hs) , NM_012871 (Rn) , NM_001081147 (Mm)

Entrez Gene

5021 (Hs) , 25342 (Rn) , 18430 (Mm)

Ensembl Gene

ENSG00000180914 (Hs) , ENSMUSG00000049112 (Mm) , ENSRNOG00000005806 (Rn)

Protein GI

9845279 (Rn) , 124487243 (Mm) , 32307152 (Hs)

GPCRdb

oxyr_human (Hs) , oxyr_mouse (Mm) , oxyr_rat (Rn)

UniProtKB ID/Entry name

OXYR_HUMAN (Hs) , OXYR_MOUSE (Mm) , OXYR_RAT (Rn)

dbSNP

rs2254298 (Hs)

DrugBank Target

P30559 (Hs)

ChEMBL Target

CHEMBL3996 (Rn) , CHEMBL2049 (Hs) , CHEMBL3243907 (Mm)

关联配体

Ligand ID	2182
名称	desmopressin
别名	1-deamino,D-AVP
类别	Peptide
学名	N-[1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Synthetic analogue of AVP. As is the case with many peptide molecules, there is ambiguity in the stereochemistry of the chemical structure of desmopressin. The structure shown here does not specify stereochemistry and so may vary from the representations shown on other resources linked to from the table above. PubChem also includes the following structures for desmopressin: (CID 16051933 and CID 5311065).
单字母多肽序列	CYFQNCPRG
三字母多肽序列	deamino-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-D-Arg-Gly-NH2
翻译后修饰
化学修饰	N-terminal cysteine residue is deamino-cysteine; arginine residue 8 is D-Arg

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[去氨基-Cys1, D-Arg8]-加压素乙酸盐水合物

库存信息

库存信息

库存信息

基本描述

名称和标识符

数据库链接

化学和物理性质

安全信息

靶标

关联配体

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[去氨基-Cys1, D-Arg8]-加压素 乙酸盐 水合物

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库存信息

库存信息

基本描述

名称和标识符

数据库链接

化学和物理性质

安全信息

靶标

关联配体

相关文档

质检报告COA

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[去氨基-Cys1, D-Arg8]-加压素乙酸盐水合物

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