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基本描述
| 英文名称 | Citrusinine II |
|---|---|
| 别名 | Citrusinine-II;compound 5 |
| 英文别名 | Citrusinine-II;compound 5 |
名称和标识符
| IUPAC Name | 1,3,5-trihydroxy-4-methoxy-10-methylacridin-9-one |
|---|---|
| INCHI | InChI=1S/C15H13NO5/c1-16-12-7(4-3-5-8(12)17)14(20)11-9(18)6-10(19)15(21-2)13(11)16/h3-6,17-19H,1-2H3 |
| InChi Key | QEGXAAUCDUFHPJ-UHFFFAOYSA-N |
| Canonical SMILES | COc1c(O)cc(c2c1n(C)c1c(c2=O)cccc1O)O |
| PubChem CID | 10016895 |
数据库链接
| PubChem CID | 10016895 |
|---|---|
| ChEMBL Ligand | CHEMBL465847 |
| BindingDB Ligand | 50336480 |
| CAS Registry No. | 86680-33-3 |
关联配体
| Ligand ID | 11377 |
|---|---|
| 名称 | Citrusinine II |
| 别名 | Citrusinine-II |
| 类别 | Natural product |
| 学名 | 1,3,5-trihydroxy-4-methoxy-10-methylacridin-9-one |
| 生物活性评价 |
Citrusinine II exhibits anti-itch activity in vivo |
| 评价 |
Citrusinine II is a natural compound found in the tropical plant Atalantia monophylla. It inhibits TRPV3 channel activity in vitro (IC50 12.43 μM) |
产品问答
产品问答
参考文献
| 1. Han Y, Luo A, Kamau PM, Takomthong P, Hu J, Boonyarat C, Luo L, Lai R. (2021) A plant-derived TRPV3 inhibitor suppresses pain and itch.. Br J Pharmacol, 178 (7): (1669-1683). [PMID:33501656] |
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