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基本描述
| 英文名称 | citibrasine |
|---|---|
| 别名 | compound 7 |
| 英文别名 | compound 7 |
名称和标识符
| IUPAC Name | 1,5-dihydroxy-2,3,4-trimethoxy-10-methylacridin-9-one |
|---|---|
| INCHI | InChI=1S/C17H17NO6/c1-18-11-8(6-5-7-9(11)19)13(20)10-12(18)15(22-2)17(24-4)16(23-3)14(10)21/h5-7,19,21H,1-4H3 |
| InChi Key | QYPQTPVQPNLXHV-UHFFFAOYSA-N |
| Canonical SMILES | COc1c(OC)c(OC)c2c(c1O)c(=O)c1c(n2C)c(O)ccc1 |
| PubChem CID | 19093029 |
数据库链接
| PubChem CID | 19093029 |
|---|---|
| ChEMBL Ligand | CHEMBL1668599 |
| CAS Registry No. | 86680-34-4 |
关联配体
| Ligand ID | 8561 |
|---|---|
| 名称 | citibrasine |
| 别名 | compound 7 [PMID: 21277783] |
| 类别 | Natural product |
| 学名 | 1,5-dihydroxy-2,3,4-trimethoxy-10-methylacridin-9-one |
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| 评价 |
Citibrasine (an acridone alkaloid derivative extracted of the stem bark of Swinglea glutinosa) is reported as a substrate-competitive inhibitor of cathepsin V |
产品问答
产品问答
参考文献
| 1. Severino RP, Guido RV, Marques EF, Br?mme D, da Silva MF, Fernandes JB, Andricopulo AD, Vieira PC. (2011) Acridone alkaloids as potent inhibitors of cathepsin V.. Bioorg Med Chem, 19 (4): (1477-81). [PMID:21277783] |
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