| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C411992-1mg | 1mg |
现货  |
| |
| C411992-5mg | 5mg |
现货 |
| |
| C411992-10mg | 10mg |
期货 |
|
| 产品名称 | Cetuximab (anti-EGFR) |
|---|---|
| 规格或纯度 | Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated |
| 特异性 | ERBB1/EGFR/HER1 |
| 应用 | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
| 反应种属 | Cynomolgus,Human,Mouse? |
| 偶联标记 | Unconjugated |
| 抗体类型 | Primary antibody |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | Kappa |
| SDS-PAGE | 28.4 kDa (Light Chain) & 53.4 kDa (Heavy Chain), under reducing conditions; 184.2 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 来源 | CHO supernatant |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | Lot by Lot |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | Store at -80℃ for 18 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS编号和信息 | 205923-56-4 |
| IMGT/mAb-DB | 151 |
|---|---|
| PubChem SID | 178103464 |
| Wikipedia | Cetuximab |
| Reactome Reaction | R-HSA-1248677 |
| Reactome Drug | R-ALL-1248673 |
| Target ID | 1797 | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | epidermal growth factor receptor | ||||||||||||||||||||||||
| 缩写名 | EGFR | ||||||||||||||||||||||||
| 家族 | Type I RTKs: ErbB (epidermal growth factor) receptor family | ||||||||||||||||||||||||
| 别名 | MAS-related GPR, member G | ||||||||||||||||||||||||
| 基因和蛋白信息 |
|
||||||||||||||||||||||||
| Ensembl Gene | ENSG00000146648 (Hs) , ENSMUSG00000020122 (Mm) , ENSRNOG00000004332 (Rn) | ||||||||||||||||||||||||
| Entrez Gene | 13649 (Mm) , 24329 (Rn) , 1956 (Hs) | ||||||||||||||||||||||||
| OMIM | 131550 (Hs) | ||||||||||||||||||||||||
| Protein GI | 46560582 (Mm) , 25742617 (Rn) , 41327736 (Hs) | ||||||||||||||||||||||||
| UniProtKB | P00533 (Hs) , Q01279 (Mm) | ||||||||||||||||||||||||
| RefSeq Nucleotide | NM_005228 (Hs) , NM_031507 (Rn) , NM_207655 (Mm) | ||||||||||||||||||||||||
| RefSeq Protein | NP_005219 (Hs) , NP_031938 (Mm) , NP_113695 (Rn) , NP_997538 (Mm) | ||||||||||||||||||||||||
| Orphanet | 121311 (Hs) | ||||||||||||||||||||||||
| DrugBank Target | P00533 (Hs) | ||||||||||||||||||||||||
| CATH/Gene3D | 3.80.20.20 (N/A) | ||||||||||||||||||||||||
| ChEMBL Target | CHEMBL3608 (Mm) , CHEMBL203 (Hs) |
| Ligand ID | 6882 |
|---|---|
| 名称 | cetuximab |
| 别名 | C225 |
| 类别 | Antibody |
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide |
| 生物活性评价 |
Peptide sequence analysis matches the light chain variable region of cetuximab to patent US7060808 |
| 评价 |
Cetuximab binds to and competitively inhibits the activity of the epidermal growth factor receptor (EGFR). Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. Biosimilars: As Bristol-Myers Squibb's original EU and US patents for cetuximab have expired, challengers of cetuximab's market position are developing biosimilar and/or biobetter cetuximab. Celltrion's CT-P15 is a cetuximab biosimilar, intended for the treatment of colorectal cancer. MabTech-Sorrento's STI-001 is a proposed biobetter cetuximab (perhaps because synthesis in CHO cells creates a different glycosylation pattern to that of cetuximab which is made in mouse cells, and may be less likely to cause side-effects such as immunogenicity and hypersensitivity). STI-001 has completed Phase 3 clinical trial in China. Neither of these agents is associated with any clinical studies that are registered with ClinicalTrials.gov. |
| 单字母多肽序列 | |
| 三字母多肽序列 | |
| 翻译后修饰 | |
| 化学修饰 |
Cetuximab (anti-EGFR) (C411992) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling EGFR (red) with Cetuximab (anti-EGFR) (C411992). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Cetuximab (anti-EGFR) (C411992) - SEC
The purity of Cetuximab (anti-EGFR) (C411992) is more than 95% verified by HPLC.
您好，这二个试剂是一样的，只是质控指标不同，分子量一个是理论值一个是实测值。
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