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基本描述

规格或纯度 95%
英文名称 Chlorpromazine
运输条件 常规运输

名称和标识符

IUPAC Name 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
INCHI InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
InChi Key ZPEIMTDSQAKGNT-UHFFFAOYSA-N
Canonical SMILES CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
PubChem CID 2726
分子量 318.9

安全和危险性(GHS)

象形图
ghs06

Toxic

ghs09

Environmental Hazard

ghs07

Harmful

信号词 Danger
危险声明 H301: Toxic if swallowed
H331: Toxic if inhaled
H317: May cause an allergic skin reaction
H400: Very toxic to aquatic life
H410: Very toxic to aquatic life with long lasting effects
H362: May cause harm to breast-fed children
预防措施声明 P261,P273,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P272,P333+P313,P362+P364,P391,P330,P263,P203,P301+P316,P318,P316

关联配体

Ligand ID 83
名称 chlorpromazine
别名 Largactil®
类别 Synthetic organic
学名 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
生物活性评价 Chlorpromazine is one of a number of drugs that are cationic amphiphilic in nature, for which anti-SARS-CoV-2 activity has been identified in drug repurposing screens. Tummino et al. (2021; bioRxiv preprint PMID: 33791693 target="_blank") suggest that this antiviral activity is most likely a result of the drug promoting phospholipidosis via disruption of lipid homeostasis.
评价 Chlorpromazine was the first antipsychotic drug to be discovered. It is one of the most sedating of the typical antipsychotics and also causes antimuscarinic effects.

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