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卡培他滨

5-氟尿嘧啶前药。抗癌剂。

规格或纯度: ≥99%

CAS编号: 154361-50-9
分子式: C₁₅H₂₂FN₃O₆
分子量: 359.35
MDL号: MFCD00930626
PubChem编号: 60953

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货号 (SKU)	包装规格	是否现货	价格	数量
C124969-250mg	250mg	现货
C124969-1g	1g	现货
C124969-5g	5g	现货
C124969-25g	25g	现货
C124969-100g	100g	现货

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thymidylate synthetase Inhibitor

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基本描述

规格或纯度	≥99%
英文名称	Capecitabine
别名	5'-脱氧-5-氟-N-[(戊氧基)羰基]胞苷
英文别名	CAPECITABINE\|154361-50-9\|Xeloda\|Capiibine\|Capecitibine\|Captabin\|Capecytabine\|Caxeta\|Xabine\|Capecitabine Sun\|Capecitabine Teva\|Capecitabine Medac\|Capecitabine Accord\|5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine\|Ro 09-1978\|capecitabina\|capecitabinum\|Ca
生化机理	Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrμg, that is enzymatically converted to 5-fluorouracil in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fluorouridine (5'-DFUR), to form 5-fluorouracil. From Wikipedia.Selective, novel oral fluoropyrimidine carbamate. Prodrug of 5-Fluorouracil . Anticancer agent. Active in vitro and in vivo .
应用	An antiproliferative 5-fluorouracil releasing compound
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	Capecitabine是一种治疗肿瘤选择性的氟嘧啶氨基甲酸酯，具有较高的瘤内5-FU水平，且毒性比5-FU低。An antiproliferative 5-fluorouracil releasing compound Capecitabine is a tumor-selective fluoropyrimidine carbamate which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. An antiproliferative 5-fluorouracil releasing compound

名称和标识符

IUPAC Name	pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate
INCHI	InChI=1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1
InChi Key	GAGWJHPBXLXJQN-UORFTKCHSA-N
Canonical SMILES	CCCCCOC(=O)NC1=NC(=O)N(C=C1F)C2C(C(C(O2)C)O)O
WGK Germany	3
关联CAS	154361-50-9
PubChem CID	60953
MeSH Entry Terms	capecitabine;N(4)-pentyloxycarbonyl-5'-deoxy-5-fluorocytidine;Xeloda
分子量	359.35

数据库链接

DrugBank Ligand	DB01101
PubChem CID	60953
CAS Registry No.	154361-50-9
ChEMBL Ligand	CHEMBL1773
Wikipedia	Capecitabine
ChEBI	CHEBI:31348
DrugCentral Ligand	480

化学和物理性质

溶解性	Soluble in water (26 mg/ml), ethanol (207 mg/ml), methanol (> 40%), DMF (~14 mg/ml), and DMSO (72 mg/ml at 25 °C).
敏感性	对热敏感
比旋光度	98° (C=1,MeOH)
熔点	123 °C(dec.)

安全和危险性（GHS）

象形图	Health Hazard Harmful
信号词	Danger
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H341: Suspected of causing genetic defects H360: May damage fertility or the unborn child H350: May cause cancer
预防措施声明	P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P281,P362+P364,P203,P264+P265,P318,P337+P317,P332+P317
WGK Germany	3
Merck Index	1754

关联配体

Ligand ID	6799
名称	capecitabine
别名	Ro-091978000
类别	Synthetic organic
学名	pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Capecitabine is a prodrug, that is enzymatically converted to 5-fluorouracil (active agent). It is a thymidylate synthase inhibitor.

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参考文献

1. Shi H et al.. (2014) Anti-angiogenesis participates in antitumor effects of metronomic capecitabine on colon cancer.. Cancer Lett, 349 (2): (128-35). [PMID:24746899]
2. Miwa M et al.. (1998) Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue.. Eur J Cancer, 34 (8): (1274-81). [PMID:9849491]
3. Terranova-Barberio M et al.. (2015) Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression.. Oncotarget, (): (). [PMID:26735339]

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