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环胞霉素A

PP2B抑制剂
规格或纯度: 98%
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
C106893-25mg
 25mg 现货 Stock Image
C106893-100mg
 100mg 现货 Stock Image
C106893-250mg
 250mg 现货 Stock Image
C106893-1g
 1g 现货 Stock Image
C106893-5g
 5g 现货 Stock Image
C106893-25g
 25g 现货 Stock Image
C106893-100g
 100g 现货 Stock Image
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ABCG2 Inhibitor FPR1 Antagonist OATP1B1 Inhibitor OATP1B3 Inhibitor peptidylprolyl isomerase A Inhibitor peptidylprolyl isomerase D Inhibitor Sodium/bile acid and sulphated solute cotransporter 1 Inhibitor
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基本描述

别名 环孢菌素A|环孢菌素|抗生素 S 7481F1|环孢素|环孢素A|环孢多肽A|环孢灵|赛斯平
规格或纯度 98%
英文名称 Cyclosporin A
应用 抑制T细胞受体信号传导路径,用于分子生物学研究。
储存温度 2-8°C储存
运输条件 冰袋运输
备注 25mg卖完停产，不再备货
产品介绍

产品介绍：

Cyclosporin A (Cyclosporine A) 是一种免疫抑制剂，能与亲环素结合，抑制 calcineurin 活性的IC50 值为 7 nM。Cyclosporin A 也抑制 CD11a/CD18 粘附分子。无臭无味。抑制T细胞受体信号传导路径,用于分子生物学研究。

名称和标识符

IUPAC Name (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
INCHI InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
InChi Key PMATZTZNYRCHOR-CGLBZJNRSA-N
Canonical SMILES CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
WGK Germany 3
RTECS GZ4120000
PubChem CID 5284373
分子量 1202.61
Beilstein号 3647785
Reaxy-Rn 3647785

化学和物理性质

溶解性 极易溶于乙醚、丙酮、甲醇、乙醇；可溶于氯仿
密度 1.016
敏感性 对热敏感 ;对光线敏感
比旋光度 -193 ° (C=0.5, MeOH)
熔点 151°C

安全和危险性（GHS）

象形图
ghs08

Health Hazard

ghs07

Harmful
信号词 Danger
危险声明 H302: Harmful if swallowed
H372: Causes damage to organs through prolonged or repeated exposure
H360: May damage fertility or the unborn child
H350: May cause cancer
预防措施声明 P280,P405,P501,P264,P260,P270,P330,P203,P301+P317,P318,P319
WGK Germany 3
RTECS GZ4120000
Reaxy-Rn 3647785
Merck Index 2752
个人防护装备 Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges

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参考文献

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