首页
400-620-6333
切换导航
搜索
基本描述
| 规格或纯度 | ≥98% |
|---|---|
| 英文名称 | Bardoxolone Methyl |
| 别名 | NSC 713200; RTA 402 |
| 英文别名 | NSC 713200; RTA 402; CDDO Methyl ester;2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester;Methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate |
| 生化机理 | Bardoxolone methyl is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs). The AIMs are potent inducers of the transcription factor Nrf2.Synthetic triterpenoid that inhibits IκBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor κB-regulated gene products in human leukemic cells. Novel therapeutic agent in the t |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 备注 | 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| 产品介绍 |
Bardoxolone Methyl是IKK抑制剂，具有强效的促凋亡和抗炎活性。 Bardoxolone Methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities. |
名称和标识符
| IUPAC Name | methyl (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylate |
|---|---|
| INCHI | InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1 |
| InChi Key | WPTTVJLTNAWYAO-KPOXMGGZSA-N |
| Canonical SMILES | CC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)C(=O)OC)C |
| PubChem CID | 400769 |
| 分子量 | 505.69 |
数据库链接
| PubChem CID | 400769 |
|---|---|
| CAS Registry No. | 218600-53-4 |
| ChEMBL Ligand | CHEMBL1762621 |
| Wikipedia | Bardoxolone methyl |
化学和物理性质
| 溶解性 | DMSO 21 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
|---|
关联配体
| Ligand ID | 3443 |
|---|---|
| 名称 | CDDO-Me |
| 别名 | 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid methyl ester |
| 类别 | Synthetic organic |
| 学名 | methyl (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylate |
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| 评价 | Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth. |
相关文档
产品问答
产品问答
上海阿拉丁生化科技股份有限公司
? 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任
危险品化学品经营许可证（带存储）