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蛙皮素醋酸盐

参与胃肠道功能

规格或纯度: ≥97% (HPLC)

CAS编号: 31362-50-2(free basis)
分子式: C₇₁H₁₁₀N₂₄O₁₈S(free basis)
分子量: 1619.85(free basis)
MDL号: MFCD00167514

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货号 (SKU)	包装规格	是否现货
B118773-1mg	1mg	现货
B118773-5mg	5mg	现货
B118773-25mg	25mg	现货
B118773-100mg	100mg	现货

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BB1 receptor Agonist BB2 receptor Agonist

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基本描述

规格或纯度	≥97% (HPLC)
英文名称	Bombesin acetate
别名	铃蟾肽醋酸盐
英文别名	Bombesin acetate
生化机理	具有许多生物学作用的神经肽，包括激素释放，刺激胰腺酶分泌，抑制胃排空和调节胃酸分泌。
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Bombesin 是一种十四肽，在胃泌素释放和 G 蛋白受体活化中起重要作用；具有多种生物活性的神经肽 pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 Bombesin is a tetradeceptide that plays an important role in gastrin release and G protein receptor activation；A neuropeptide with diverse biological activities Application： Gut tetradecapeptide with the ability to stimulate release of various hormones

名称和标识符

分子式	C₇₁H₁₁₀N₂₄O₁₈S(free basis)
分子量	1619.85(free basis)

数据库链接

PubChem CID	16133800
Wikipedia	Bombesin
ChEMBL Ligand	CHEMBL437027
CAS Registry No.	31362-50-2
GPCRdb Ligand	bombesin

化学和物理性质

溶解性	Soluble in 0.05M acetic acid (20mg/ml)

靶标

Target ID

名称

BB₁ receptor

缩写名

SHP2

家族

Bombesin receptors

别名

5-HT_5α

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	390	1p13	Nmbr	neuromedin B receptor
Human	7	390	6q24.1	NMBR	neuromedin B receptor
Mouse	7	390	10 A2	Nmbr	neuromedin B receptor

RefSeq Protein

NP_036931 (Rn) , NP_002502 (Hs) , NP_032729 (Mm)

UniProtKB

P24053 (Rn) , P28336 (Hs) , O54799 (Mm)

OMIM

162341 (Hs)

RefSeq Nucleotide

NM_002511 (Hs) , NM_012799 (Rn) , NM_008703 (Mm)

Entrez Gene

4829 (Hs) , 25264 (Rn) , 18101 (Mm)

Ensembl Gene

ENSG00000135577 (Hs) , ENSMUSG00000019865 (Mm) , ENSRNOG00000012103 (Rn)

Protein GI

6981274 (Rn) , 6679076 (Mm) , 161484640 (Hs)

GPCRdb

nmbr_human (Hs) , nmbr_mouse (Mm) , nmbr_rat (Rn)

UniProtKB ID/Entry name

NMBR_HUMAN (Hs) , NMBR_MOUSE (Mm) , NMBR_RAT (Rn)

ChEMBL Target

CHEMBL4440 (Rn) , CHEMBL3636 (Hs)

Target ID

名称

BB₂ receptor

缩写名

SHP2

家族

Bombesin receptors

别名

5-HT_5α

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	384	Xq14	Grpr	gastrin releasing peptide receptor
Human	7	384	Xp22.2	GRPR	gastrin releasing peptide receptor
Mouse	7	384	X 75.63 cM	Grpr	gastrin releasing peptide receptor

RefSeq Protein

NP_036838 (Rn) , NP_005305 (Hs) , NP_032203 (Mm)

UniProtKB

P52500 (Rn) , P30550 (Hs) , P21729 (Mm)

OMIM

305670 (Hs)

RefSeq Nucleotide

NM_005314 (Hs) , NM_012706 (Rn) , NM_008177 (Mm)

Entrez Gene

2925 (Hs) , 24938 (Rn) , 14829 (Mm)

Ensembl Gene

ENSG00000126010 (Hs) , ENSMUSG00000031364 (Mm) , ENSRNOG00000004124 (Rn)

Protein GI

6980990 (Rn) , 4885361 (Hs) , 6680111 (Mm)

GPCRdb

grpr_human (Hs) , grpr_mouse (Mm) , grpr_rat (Rn)

UniProtKB ID/Entry name

GRPR_HUMAN (Hs) , GRPR_MOUSE (Mm) , GRPR_RAT (Rn)

ChEMBL Target

CHEMBL3596 (Mm) , CHEMBL4280 (Rn) , CHEMBL4959 (Hs)

关联配体

Ligand ID	616
名称	bombesin
类别	Peptide
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Originally isolated from the skin of Bombina orientalis (oriental fire-bellied toad). As with many natural peptide ligands, there is some ambiguity in the literature and on other resources as to the exact stereochemistry of bombesin. The structure shown here matches those in the PubChem and ChEMBL entries that can be accessed via the Database Links table.
单字母多肽序列	XQRLGNQWAVGHLM
三字母多肽序列	pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
翻译后修饰	C-terminal amidation of methionine; pyroglutamate formation at N-terminus
化学修饰