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Tigatuzumab (anti-TNFRSF10B)

功能和特点

规格或纯度: Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
反应种属: Cynomolgus,Human
亚型: Human IgG1

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库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU)	包装规格	是否现货	价格	数量
Ab175677-100μg (试用装) 申请此免费试用装（?）作为尊贵的客户，您每年可免费申请三次您选择的不同货号试用装产品，尽享探索与享受！	100μg	期货
Ab175677-1mg	1mg	期货
Ab175677-5mg	5mg	期货
Ab175677-10mg	10mg	期货

查看相关系列

Accession#:O14763 CD262 death receptor 5 Antibody DR5 Gene ID:8795 TNFRSF10B

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基本信息

产品名称	Tigatuzumab (anti-TNFRSF10B)
规格或纯度	Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
特异性	TNFRSF10B
反应种属	Cynomolgus,Human
偶联标记	Unconjugated

产品属性

克隆	Recombinant
Format	Whole IgG
亚型	Human IgG1
轻链亚型	Kappa
SDS-PAGE	26.3 kDa (Light Chain) & 49.8 kDa (Heavy Chain), under reducing conditions; 177.0 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	Lot by Lot
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS编号和信息	918127-53-4

数据库链接

IMGT/mAb-DB	234

关联配体

Ligand ID	9334
名称	tigatuzumab
别名	CS-1008
类别	Antibody
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	The affinity of the humanized antibody is not provided in , however the affinity of the original mouse anti-DR5 antibody (TRA-8) from which tigatuzumab is derived provides an approximate affinity (provided in the interaction table below).
评价	Tigatuzumab (CS-1008) is an investigational, humanized agonistic monoclonal antibody directed against human death receptor 5 (TNFRSF10B; a TNF family catalytic receptor for TRAIL), which is expressed on the surface of many types of cancer cells. DR5 contains an intracellular death domain and interacts with FADD (Fas-associated protein with death domain) to mediate apoptisis. Peptide sequences and structural information for this antibody are available from its IMGT/mAb-DB record. Peptide sequences matching the heavy and light chain variable regions of tigatuzumab are claimed in patent WO2001083560 , but this does not provide an affinity value for the antibody vs. DR5. The antibodies described in the patent were tetsed for their ability to induce apoptosis in cells expressing DR5.
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