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lifastuzumab vedotin

功能和特点

有货

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
Ab175578-1mg	1mg	期货
Ab175578-5mg	5mg	期货

查看相关系列

Sodium phosphate 2 Antibody

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基本信息

产品名称	lifastuzumab vedotin

产品属性

CAS编号和信息	Ab175578

数据库链接

Wikipedia	Lifastuzumab vedotin
IMGT/mAb-DB	478

靶标

Target ID

1136

名称

Sodium phosphate 2

缩写名

NaPi-IIb

家族

SLC34 family of sodium phosphate co-transporters

别名

glucocorticoid-induced receptor

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	8	690	4p15.2	SLC34A2	solute carrier family 34 member 2
Mouse	8	697	5 28.92 cM	Slc34a2	solute carrier family 34 (sodium phosphate), member 2
Rat	8	695	14q11	Slc34a2	solute carrier family 34 member 2

Ensembl Gene

ENSG00000157765 (Hs) , ENSMUSG00000029188 (Mm) , ENSRNOG00000004626 (Rn)

Entrez Gene

20531 (Mm) , 84395 (Rn) , 10568 (Hs)

OMIM

604217 (Hs)

Protein GI

295789160 (Hs) , 16758110 (Rn) , 66793411 (Mm)

UniProtKB

O95436 (Hs) , Q9DBP0 (Mm) , Q9JJ09 (Rn)

Bioparadigms SLC Tables

SLC34A2 (Hs)

RESOLUTE

SLC34A2 (Hs)

ChEMBL Target

CHEMBL4295685 (Hs)

关联配体

Ligand ID	8405
名称	lifastuzumab vedotin
别名	DNIB0600A
类别	Antibody
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	Patent US8535675 identifies clone 10H1.11.4B, as the lead which went on to be conjugated to the toxin payload, but does not provide an affinity value for this monoclonal's binding to SLC34A2. The primary target is tagged based on biological evidence provided in the patent.
评价	Lifastuzumab vedotin is an antibody drug conjugate containing an anti-SLC34A2 (sodium phosphate 2 transporter) monoclonal antibody linked to the toxin monomethyl auristatin E (MMAE, aka vedotin; PubChem CID 11542188). Peptide sequence information for this antibody is available from its IMGT/mAb-DB record. Peptide sequence match identifies US8535675 as the covering patent , and also identifies the target antigen denoted as TAT211 in this patent as the sodium phosphate transporter.
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