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Benralizumab (anti-IL-5Ra)

Benralizumab (anti-IL-5Ra)

功能和特点

规格或纯度: Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
反应种属: Human,Mouse?,Rabbit?,Rat?
亚型: Human IgG1

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库存信息

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库存信息

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库存信息

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货号 (SKU)	包装规格	是否现货	价格	数量
Ab175469-100μg (试用装) 申请此免费试用装（?）作为尊贵的客户，您每年可免费申请三次您选择的不同货号试用装产品，尽享探索与享受！	100μg	期货
Ab175469-1mg	1mg	期货
Ab175469-5mg	5mg	期货
Ab175469-10mg	10mg	期货

查看相关系列

Accession#:Q01344 Gene ID:3568 IL5RA Interleukin 5 receptor，α subunit Antibody

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基本信息

产品名称	Benralizumab (anti-IL-5Ra)
别名	贝那利珠单抗
规格或纯度	Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
特异性	IL5RA
反应种属	Human,Mouse?,Rabbit?,Rat?
偶联标记	Unconjugated

产品属性

克隆	Recombinant
Format	Whole IgG
亚型	Human IgG1
轻链亚型	Kappa
SDS-PAGE	26.9 kDa (Light Chain) & 52.8 kDa (Heavy Chain), under reducing conditions; 193.8 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	Lot by Lot
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS编号和信息	1044511-01-4

数据库链接

IMGT/mAb-DB	334
Wikipedia	Benralizumab
ChEMBL Ligand	CHEMBL1742991
PEP	benralizumab

图片

ELISA: Benralizumab (anti-IL-5Ra) (Ab175469)

Benralizumab (anti-IL-5Ra) (Ab175469) - ELISA
Immobilized huIL-5Rα-his at 2.0 μg/mL can bind Benralizumab (anti-IL-5Ra) (Ab175469) with the EC?? of 16.39 ng/mL.

SEC: Benralizumab (anti-IL-5Ra) (Ab175469)

Benralizumab (anti-IL-5Ra) (Ab175469) - SEC
The purity of Benralizumab (anti-IL-5Ra) (Ab175469) is more than 95% verified by HPLC.

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参考文献

1. Ghazi A, Trikha A, Calhoun WJ. (2012) Benralizumab--a humanized mAb to IL-5Rα with enhanced antibody-dependent cell-mediated cytotoxicity--a novel approach for the treatment of asthma.. Expert Opin Biol Ther, 12 (1): (113-8). [PMID:22136436]
2. FitzGerald JM, Bleecker ER, Nair P, Korn S, Ohta K, Lommatzsch M, Ferguson GT, Busse WW, Barker P, Sproule S et al.. (2016) Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial.. Lancet, 388 (10056): (2128-2141). [PMID:27609406]
3. Castro M, Wenzel SE, Bleecker ER, Pizzichini E, Kuna P, Busse WW, Gossage DL, Ward CK, Wu Y, Wang B et al.. (2014) Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study.. Lancet Respir Med, 2 (11): (879-90). [PMID:25306557]
4. Mukherjee M, Sehmi R, Nair P. (2014) Anti-IL5 therapy for asthma and beyond.. World Allergy Organ J, 7 (1): (32). [PMID:25709744]
5. Morokata T, Ida K, Yamada T. (2002) Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor.. Int Immunopharmacol, 2 (12): (1693-702). [PMID:12469943]

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