91高清自产国产拍,无码免费A级毛片大全,日本欧美国产中文字幕,99re热视频这里只有精品视频首页

首页

400-620-6333

提交您使用阿拉丁产品的研究文章，就得100元奖励！立即访问我们的提交页面.

跳到内容

语言

切换导航

我的购物车

搜索

菜单

账号

设置

语言

ASC06-IgG1

有货

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
Ab175457-1mg	1mg	期货
Ab175457-5mg	5mg	期货

查看相关系列

ASIC1 Channel blocker

Skip to the end of the images gallery

Skip to the beginning of the images gallery

基本信息

产品名称	ASC06-IgG1

产品属性

CAS编号和信息	Ab175457

靶标

Target ID

684

名称

ASIC1

缩写名

SHP2

家族

Acid-sensing (proton-gated) ion channels (ASICs)

别名

NLR

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	2	528	12q13.12	ASIC1	acid sensing ion channel subunit 1
Mouse	2	526	15 F1	Asic1	acid-sensing (proton-gated) ion channel 1
Rat	2	526	7q36	Asic1	acid sensing ion channel subunit 1

Entrez Gene

41 (Hs) , 11419 (Mm) , 79123 (Rn)

OMIM

602866 (Hs)

UniProtKB

P78348 (Hs) , Q6NXK8 (Mm) , P55926 (Rn)

Ensembl Gene

ENSG00000110881 (Hs) , ENSMUSG00000023017 (Mm) , ENSRNOG00000059765 (Rn)

Protein GI

378744190 (Hs) , 13162349 (Rn) , 45433493 (Mm)

DrugBank Target

P78348 (Hs)

ChEMBL Target

CHEMBL1628477 (Hs) , CHEMBL3232694 (Mm) , CHEMBL3562170 (Rn)

关联配体

Ligand ID	12564
名称	ASC06-IgG1
类别	Antibody
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	ASC06-IgG1 is a antibody that inhibits ASIC1a channel activity . It binds to the structurally intact channel in the upper part of the extracellular domain with substantial contact on the finger domain and is highly selective for ASIC1a over other subtypes.
单字母多肽序列
三字母多肽序列
翻译后修饰
化学修饰

参考文献

1. Qiang M, Dong X, Zha Z, Zuo XK, Song XL, Zhao L, Yuan C, Huang C, Tao P, Hu Q et al.. (2018) Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death.. Proc Natl Acad Sci U S A, 115 (32): (E7469-E7477). [PMID:30042215]