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1-[3-[5-(3-aminophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
- PubChem编号: 76332060
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基本描述
| 英文名称 | 1-[3-[5-(3-aminophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea |
|---|---|
| 别名 | compound 21 |
| 英文别名 | compound 21 |
名称和标识符
| IUPAC Name | 1-[3-[5-(3-aminophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea |
|---|---|
| INCHI | InChI=1S/C27H19F4N5O/c28-23-8-7-18(27(29,30)31)12-24(23)36-26(37)35-20-6-2-4-16(10-20)22-14-34-25-21(22)11-17(13-33-25)15-3-1-5-19(32)9-15/h1-14H,32H2,(H,33,34)(H2,35,36,37) |
| InChi Key | QQTPMHCXBYRWFQ-UHFFFAOYSA-N |
| Canonical SMILES | O=C(Nc1cc(ccc1F)C(F)(F)F)Nc1cccc(c1)c1c[nH]c2c1cc(cn2)c1cccc(c1)N |
| PubChem CID | 76332060 |
数据库链接
| PubChem CID | 76332060 |
|---|---|
| ChEMBL Ligand | CHEMBL3109212 |
关联配体
| Ligand ID | 8187 |
|---|---|
| 名称 | compound 21 [PMID: 24900635] |
| 类别 | Synthetic organic |
| 学名 | 1-[3-[5-(3-aminophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea |
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| 评价 |
Compound 21 is a derivative synthesised and assessed in a medicinal chemistry study to identify potent small molecule inhibitors of receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) |
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参考文献
| 1. Smith CC, Davidson SM, Lim SY, Simpkin JC, Hothersall JS, Yellon DM. (2007) Necrostatin: a potentially novel cardioprotective agent?. Cardiovasc Drugs Ther, 21 (4): (227-33). [PMID:17665295] |
| 2. Rosenbaum DM, Degterev A, David J, Rosenbaum PS, Roth S, Grotta JC, Cuny GD, Yuan J, Savitz SI. (2010) Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model.. J Neurosci Res, 88 (7): (1569-76). [PMID:20025059] |
| 3. Xu X, Chua KW, Chua CC, Liu CF, Hamdy RC, Chua BH. (2010) Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury.. Brain Res, 1355 (13): (189-94). [PMID:20682300] |
| 4. Trichonas G, Murakami Y, Thanos A, Morizane Y, Kayama M, Debouck CM, Hisatomi T, Miller JW, Vavvas DG. (2010) Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis.. Proc Natl Acad Sci USA, 107 (50): (21695-700). [PMID:21098270] |
| 5. Linkermann A, Br?sen JH, Himmerkus N, Liu S, Huber TB, Kunzendorf U, Krautwald S. (2012) Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury.. Kidney Int, 81 (8): (751-61). [PMID:22237751] |
| 6. Galluzzi L, Kroemer G. (2011) Necroptosis turns TNF lethal.. Immunity, 35 (6): (849-51). [PMID:22195740] |
| 7. Harris PA, Bandyopadhyay D, Berger SB, Campobasso N, Capriotti CA, Cox JA, Dare L, Finger JN, Hoffman SJ, Kahler KM et al.. (2013) Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis.. ACS Med Chem Lett, 4 (12): (1238-43). [PMID:24900635] |
| 8. Pasparakis M, Vandenabeele P. (2015) Necroptosis and its role in inflammation.. Nature, 517 (7534): (311-20). [PMID:25592536] |
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