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AZ11657312 (salt free)

PubChem编号: 11193842

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库存信息

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库存信息

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货号 (SKU)	包装规格	是否现货	价格	数量
A607829-5mg	5mg	期货
A607829-25mg	25mg	期货

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P2X7 Antagonist

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基本描述

英文名称	AZ11657312 (salt free)

名称和标识符

IUPAC Name	2-(1-adamantyl)-N-[2-methyl-5-(9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carbonyl)phenyl]acetamide
INCHI	InChI=1S/C26H35N3O3/c1-16-2-3-20(25(31)29-14-21-12-27-13-22(15-29)32-21)7-23(16)28-24(30)11-26-8-17-4-18(9-26)6-19(5-17)10-26/h2-3,7,17-19,21-22,27H,4-6,8-15H2,1H3,(H,28,30)
InChi Key	XYNNEMHCLNODBL-UHFFFAOYSA-N
Canonical SMILES	O=C(CC12CC3CC(C2)CC(C1)C3)Nc1cc(ccc1C)C(=O)N1CC2CNCC(C1)O2
PubChem CID	11193842

数据库链接

PubChem CID	11193842
ChEMBL Ligand	CHEMBL550637

关联配体

Ligand ID	7722
名称	AZ11657312 (salt free)
类别	Synthetic organic
学名	2-(1-adamantyl)-N-[2-methyl-5-(9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carbonyl)phenyl]acetamide
生物活性评价	Note that bioactivity will be associated with the hydrochloride salt. Pending publication, the data presented here is derived from the compound's record in
评价	The monohydrochloride is described in the article , which provides the IUPAC name, 2-(adamantan-1-yl)-N-[2-methyl-5-(9-oxa-3,7-diazabicyclo[3.3.1]non-3-ylcarbonyl)phenyl]acetamide monohydrochloride, for this compound. We represent the molecule here, without the hydrochloride. AZ11657312 is an antagonist of the purinergic receptor 2X, ligand-gated ion channel 7 (P2X7) which is implicated the molecular mechanisms underlying pain and inflammation, as its activation leads to the release of proinflammatory cytokines such as interleukin (IL)-1, tumor necrosis factor (TNF)-α, and IL-6 . AZ11657312 has been investigated as an antiinflammatory treatment for conditions such as COPD, Crohn's disease and osteo- and rheumatoid arthritis. This compound is now included in .

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参考文献

1. Lister MF, Sharkey J, Sawatzky DA, Hodgkiss JP, Davidson DJ, Rossi AG, Finlayson K. (2007) The role of the purinergic P2X7 receptor in inflammation.. J Inflamm (Lond.), 4 (13): (5). [PMID:17367517]
2. Donnelly-Roberts DL, Jarvis MF. (2007) Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states.. Br J Pharmacol, 151 (5): (571-9). [PMID:17471177]
3. Broom DC, Matson DJ, Bradshaw E, Buck ME, Meade R, Coombs S, Matchett M, Ford KK, Yu W, Yuan J et al.. (2008) Characterization of N-(adamantan-1-ylmethyl)-5-[(3R-amino-pyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X7 antagonist in animal models of pain and inflammation.. J Pharmacol Exp Ther, 327 (3): (620-33). [PMID:18772321]

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