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基本描述
| 英文名称 | ASP2453 |
|---|
名称和标识符
| IUPAC Name | 1-[7-(6-cyclopropyl-2-{[4-(3-methoxypropyl)cyclohexyl]oxy}-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)quinazolin-4-yl)-2,7-diazaspiro[3.5]nonan-2-yl]prop-2-en-1-one |
|---|---|
| INCHI | InChI=1S/C41H49F3N6O4/c1-4-33(51)50-22-40(23-50)15-17-49(18-16-40)38-30-20-29(27-10-11-27)35(34-25(2)7-14-32-31(34)21-45-48-32)37(53-24-41(42,43)44)36(30)46-39(47-38)54-28-12-8-26(9-13-28)6-5-19-52-3/h4,7,14,20-21,26-28H,1,5-6,8-13,15-19,22-24H2,2-3H3,(H,45,48) |
| InChi Key | YNLGBBXDUCMNPY-UHFFFAOYSA-N |
| Canonical SMILES | COCCCC1CCC(CC1)Oc1nc(N2CCC3(CN(C3)C(=O)C=C)CC2)c2cc(C3CC3)c(c(OCC(F)(F)F)c2n1)c1c2cn[nH]c2ccc1C |
| PubChem CID | 162679534 |
数据库链接
| PubChem CID | 162679534 |
|---|
关联配体
| Ligand ID | 11839 |
|---|---|
| 名称 | ASP2453 |
| 类别 | Synthetic organic |
| 学名 | 1-[7-(6-cyclopropyl-2-{[4-(3-methoxypropyl)cyclohexyl]oxy}-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)quinazolin-4-yl)-2,7-diazaspiro[3.5]nonan-2-yl]prop-2-en-1-one |
| 生物活性评价 |
ASP2453 is active in vitro and in preclinical models of KRASG12C-mutated cancer |
| 评价 |
ASP2453 is an oral, covalent inhibitor of the mutant KRASG12C protein |
产品问答
产品问答
参考文献
| 1. Nakayama A, Nagashima T, Nishizono Y, Kuramoto K, Mori K, Homboh K, Yuri M, Shimazaki M. (2021) Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models.. Br J Cancer, 71 (13): (1755-70). [PMID:34795410] |
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