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Asapiprant

规格或纯度: 98%

CAS编号: 932372-01-5
分子式: C₂₄H₂₇N₃O₇S
分子量: 501.55
PubChem编号: 59232326

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货号 (SKU)	包装规格	是否现货	价格	数量
A412177-1mg	1mg	期货
A412177-5mg	5mg	期货
A412177-10mg	10mg	期货
A412177-25mg	25mg	期货
A412177-50mg	50mg	期货

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DP1 receptor Antagonist

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基本描述

规格或纯度	98%
英文名称	Asapiprant
英文别名	Asapiprant\|932372-01-5\|Asapiprant [INN]\|BGE-175\|BGE175\|B2LW71CRGL\|S-555739\|2-(5-(4-((4-isopropoxyphenyl)sulfonyl)piperazin-1-yl)-2-(oxazol-2-yl)phenoxy)acetic acid\|2-(2-(Oxazol-2-yl)-5-(4-(4-((propan-2-yl)oxy)benzenesulfonyl(piperazin-1-yl)phenoxy)acetic
生化机理	Asapiprant (S-555739) is a potent and selective antagonist for DP1 receptor with Ki of 0.44 nM.
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Information Asapiprant (S-555739) is a potent and selective antagonist for DP1 receptor with Ki of 0.44 nM.

名称和标识符

IUPAC Name	2-[2-(1,3-oxazol-2-yl)-5-[4-(4-propan-2-yloxyphenyl)sulfonylpiperazin-1-yl]phenoxy]acetic acid
INCHI	InChI=1S/C24H27N3O7S/c1-17(2)34-19-4-6-20(7-5-19)35(30,31)27-12-10-26(11-13-27)18-3-8-21(24-25-9-14-32-24)22(15-18)33-16-23(28)29/h3-9,14-15,17H,10-13,16H2,1-2H3,(H,28,29)
InChi Key	ZMZNWNTZRWXTJU-UHFFFAOYSA-N
Canonical SMILES	CC(C)OC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C3=CC(=C(C=C3)C4=NC=CO4)OCC(=O)O
关联CAS	932372-01-5
PubChem CID	59232326
MeSH Entry Terms	2-(2-(oxazol-2-yl)-5-(4-(4-((propan-2-yl)oxy)benzenesulfonyl(piperazin-1-yl)phenoxy)acetic acid;asapiprant;BGE 175;BGE-175;S-555739
分子量	501.55

关联配体

Ligand ID	11951
名称	asapiprant
别名	BGE-175
类别	Synthetic organic
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Asapiprant (S-555739) is a DP₁ receptor antagonist that was developed for anti-inflammatory potential . It has been used in an animal model of COVID-19 to indicate that targeting the PLA₂G2D-PGD₂/DP₁ receptor pathway provides some benefit in protecting aged mice from lethal virus infection . A clinical study in a select subset of human COVID-19 patients is underway (as of April 2022).
临床描述	The primary objective of the study was to examine the efficacy and safety of S-555739/cetirizine HCl compared with the individual components and placebo. The primary objectives of this study are to evaluate the safety, tolerability, and efficacy of BGE-175 in participants ≥ 50 years of age hospitalized with documented COVID-19.
来源公司	Shionogi Inc. BioAge Labs, Inc.

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参考文献

1. Takahashi G, Asanuma F, Suzuki N, Hattori M, Sakamoto S, Kugimiya A, Tomita Y, Kuwajima G, Abraham WM, Deguchi M et al.. (2015) Effect of the potent and selective DP1 receptor antagonist, asapiprant (S-555739), in animal models of allergic rhinitis and allergic asthma.. Eur J Pharmacol, 765 (13): (15-23). [PMID:26277322]
2. Wong LR, Zheng J, Wilhelmsen K, Li K, Ortiz ME, Schnicker NJ, Thurman A, Pezzulo AA, Szachowicz PJ, Li P et al.. (2022) Eicosanoid signaling blockade protects middle-aged mice from severe COVID-19.. Nature, 71 (13): (1755-70). [PMID:35314834]

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