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5'-腺苷酸

规格或纯度: ≥98.0%(HPLC)

CAS编号: 61-19-8
分子式: C₁₀H₁₄N₅O₇P
分子量: 347.22
Beilstein号: 31,27
MDL号: MFCD00005750
PubChem编号: 6083

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货号 (SKU)	包装规格	是否现货
A136967-5g	5g	现货
A136967-25g	25g	现货
A136967-100g	100g	现货
A136967-500g	500g	现货
A136967-2.5kg	2.5kg	现货

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AMP kinase Activator TRPM4 Gating inhibitor

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基本描述

规格或纯度	≥98.0%(HPLC)
英文名称	5'-Adenylic Acid
别名	腺苷5′-一磷酸；腺苷-5'-单磷酸；5'-腺嘌呤核苷酸5'-AMP;磷酸腺苷
英文别名	Adenosine 5'-Monophosphate;5'-AMP;Adenylic acid;Adenosine-5'-monophosphoric acid
应用	A useful ligand determinant that facilitates the binding of APS reductase inhibitors.
储存温度	2-8°C储存,充氩
运输条件	冰袋运输
产品介绍	Adenosine phosphate (Vitamin B8) is a natural occurring nucleotide and a useful ligand determinant that facilitates the binding of APS reductase inhibitors and activates adenosine receptor agonists.A useful ligand determinant that facilitates the binding of APS reductase inhibitors. Adenosine phosphate (Vitamin B8) is a natural occurring nucleotide and a useful ligand determinant that facilitates the binding of APS reductase inhibitors and activates adenosine receptor agonists. A useful ligand determinant that facilitates the binding of APS reductase inhibitors.

名称和标识符

IUPAC Name	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
INCHI	InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChi Key	UDMBCSSLTHHNCD-KQYNXXCUSA-N
Canonical SMILES	C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O)N
分子式	C₁₀H₁₄N₅O₇P
PubChem CID	6083
Beilstein号	31,27
分子量	347.22

数据库链接

PubChem CID	6083
ChEBI	CHEBI:16027
CAS Registry No.	61-19-8
Wikipedia	Adenosine_monophosphate
ChEMBL Ligand	CHEMBL752
BindingDB Ligand	18137
DrugBank Ligand	DB00131
RCSB PDB Ligand	A, AMP
DrugCentral Ligand	92

化学和物理性质

溶解性	Soluble in water, and sodium hydroxide solution.
敏感性	对湿度和光线敏感
熔点	190°

安全信息

象形图	Harmful
信号词	Warning
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation H317: May cause an allergic skin reaction
预防措施声明	P261,P305+P351+P338
Merck Index	158

靶标

Target ID

496

名称

TRPM4

缩写名

SHP2

家族

Transient Receptor Potential channels (TRP)

别名

MIP-1αRL-2 (mouse)

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	6	1214	19q13.33	TRPM4	transient receptor potential cation channel subfamily M member 4
Rat	6	1208	1q22	Trpm4	transient receptor potential cation channel, subfamily M, member 4
Mouse	6	1213	7 B3	Trpm4	transient receptor potential cation channel, subfamily M, member 4

OMIM

606936 (Hs)

Entrez Gene

171143 (Rn) , 68667 (Mm) , 54795 (Hs)

UniProtKB

Q8TD43 (Hs) , Q9ESQ5 (Rn) , Q7TN37 (Mm)

RefSeq Protein

NP_060106 (Hs) , NP_001129701 (Rn) , NP_780339 (Mm)

RefSeq Nucleotide

NM_017636 (Hs) , NM_001136229 (Rn) , NM_175130 (Mm)

Ensembl Gene

ENSG00000130529 (Hs) , ENSMUSG00000038260 (Mm) , ENSRNOG00000020714 (Rn)

Orphanet

209301 (Hs)

Protein GI

304766677 (Hs) , 209977101 (Rn) , 157824093 (Mm)

ChEMBL Target

CHEMBL1628469 (Hs)

Target ID	1540
名称	AMP kinase
缩写名	AMPK
家族	AMPK subfamily

关联配体

Ligand ID	2455
名称	adenosine 5'-monophosphate
别名	5'-AMP
类别	Metabolite
学名	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth.