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阿奇霉素

规格或纯度: 分析标准品

CAS编号: 83905-01-5
分子式: C₃₈H₇₂N₂O₁₂
分子量: 748.98
MDL号: MFCD00873574
PubChem编号: 447043

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库存信息

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货号 (SKU)	包装规格	是否现货	价格	数量
A134451-25mg	25mg	现货

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motilin receptor Agonist TAS2R4 Agonist

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基本描述

规格或纯度	分析标准品
英文名称	Azithromycin
运输条件	常规运输

名称和标识符

IUPAC Name	(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
INCHI	InChI=1S/C38H72N2O12/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28/h20-33,35,41-43,45-46H,15-19H2,1-14H3/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
InChi Key	MQTOSJVFKKJCRP-BICOPXKESA-N
Canonical SMILES	CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O
分子式	C₃₈H₇₂N₂O₁₂
PubChem CID	447043
分子量	748.98

数据库链接

DrugBank Ligand	DB00207
CAS Registry No.	83905-01-5
Wikipedia	Azithromycin
PubChem CID	447043
ChEMBL Ligand	CHEMBL529
RCSB PDB Ligand	ZIT
DrugCentral Ligand	276
Antibiotic DB	1342
GPCRdb Ligand	azithromycin

安全信息

象形图	Health Hazard Environmental Hazard Harmful
信号词	Danger
危险声明	H317: May cause an allergic skin reaction H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled H400: Very toxic to aquatic life H410: Very toxic to aquatic life with long lasting effects H372: Causes damage to organs through prolonged or repeated exposure
预防措施声明	P261,P273,P280,P302+P352,P321,P501,P264,P260,P284,P270,P304+P340,P272,P333+P313,P362+P364,P391,P319,P342+P316
WGK Germany	2
RTECS	RN6960000
个人防护装备	Eyeshields, Faceshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

靶标

Target ID

297

名称

motilin receptor

缩写名

SHP2

家族

Motilin receptor

别名

AII α

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	7	412	13q14.2	MLNR	motilin receptor

RefSeq Protein

NP_001498 (Hs)

UniProtKB

O43193 (Hs)

OMIM

602885 (Hs)

RefSeq Nucleotide

NM_001507 (Hs)

Entrez Gene

2862 (Hs)

Ensembl Gene

ENSG00000102539 (Hs)

Protein GI

4504095 (Hs)

GPCRdb

mtlr_human (Hs)

UniProtKB ID/Entry name

MTLR_HUMAN (Hs)

ChEMBL Target

CHEMBL2203 (Hs)

Target ID

661

名称

TAS2R4

缩写名

SHP2

家族

Taste 2 receptors

别名

LESTR

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	7	299	7q34	TAS2R4	taste 2 receptor member 4

Entrez Gene

50832 (Hs)

OMIM

604869 (Hs)

UniProtKB

Q9NYW5 (Hs)

Ensembl Gene

ENSG00000127364 (Hs)

RefSeq Nucleotide

NM_016944 (Hs)

Protein GI

8394402 (Hs)

GPCRdb

ta2r4_human (Hs)

BitterDB Receptor

4 (Hs)

UniProtKB ID/Entry name

TA2R4_HUMAN (Hs)

ChEMBL Target

CHEMBL3309107 (Hs)

关联配体

Ligand ID	6510
名称	azithromycin
类别	Synthetic organic
学名	(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
生物活性评价	Azithromycin, like a number of other antibacterials including and , kills the malaria parasite in the lifecycle after treatment starts . Consistent with this slow clinical action, the results provided in the interactions table below show that azithromycin is more potent in vitro against erythrocytic stage parasites when assessed two asexual life cycles after the initiation of treatment.
评价	Azithromycin is a macrolide antibacterial with broad-spectrum activity against Gram-positive and atypical bacteria. The compound also has antimalarial activity. Azithromycin is one of the watch group antibacterials in the the World Health Organization's Model List of Essential Medicines (link provided in the Classification table below). The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
配体家族	Antimalarial ligands

参考文献

1. Dahl EL, Rosenthal PJ. (2007) Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast.. Antimicrob Agents Chemother, 51 (10): (3485-90). [PMID:17698630]
2. van Eijk AM, Terlouw DJ. (2011) Azithromycin for treating uncomplicated malaria.. Cochrane Database Syst Rev, 71 (2): (CD006688). [PMID:21328286]
3. Zhang Y, Ge L, Song G, Zhang R, Li S, Shi H, Zhang H, Li Y, Pan J, Wang L et al.. (2022) Azithromycin alleviates the severity of rheumatoid arthritis by targeting the unfolded protein response component of glucose-regulated protein 78 (GRP78).. Br J Pharmacol, 179 (6): (1201-1219). [PMID:34664264]