91高清自产国产拍,无码免费A级毛片大全,日本欧美国产中文字幕,99re热视频这里只有精品视频首页

首页

400-620-6333

提交您使用阿拉丁产品的研究文章，就得100元奖励！立即访问我们的提交页面.

跳到内容

语言

切换导航

我的购物车

搜索

菜单

账号

设置

语言

阿西替尼

强效的VEGFR-1，-2和-3抑制剂

规格或纯度: ≥99%

CAS编号: 319460-85-0
分子式: C₂₂H₁₈N₄OS
分子量: 386.47
MDL号: MFCD09837898
PubChem编号: 6450551

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货
A129732-10mg	10mg	现货
A129732-50mg	50mg	现货
A129732-250mg	250mg	现货
A129732-1g	1g	现货
A129732-5g	5g	期货

查看相关系列

kinase insert domain receptor Inhibitor polo like kinase 4 Inhibitor

Skip to the end of the images gallery

Skip to the beginning of the images gallery

基本描述

规格或纯度	≥99%
英文名称	Axitinib
别名	阿西替尼；N-甲基-2-((3-((1E)-2-(吡啶-2-基)乙烯)-1H-吲唑-6-基)硫)苯甲酰胺
英文别名	AG-013736; N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide;Axitinib
生化机理	VEGFR-2，-3和-1的有效抑制剂（IC50值分别为0.2、0.1-0.3和1.2 nM）。对一组约100种蛋白激酶的活性最低。抑制血管生成和血管通透性。也是一种高亲和力的BCR-ABL1（T315I）抑制剂（自磷酸化ABL1（T315I）的Ki = 149 pM）。阻止表达BCR-ABL1（T315I）的Ba / F3细胞的增殖。口服。
应用	An inhibitor of Flt and Flk (VEGFR) with antitumor properties
法律信息	Sold for research purposes under agreement from Pfizer Inc. - Not for human or veterinary use.
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Axitinib is a non-selective receptor kinase inhibitor of Flt and Flk proteins. This compound also inhibits Flt-1(VEGFR-1), Flk-1(VEGFR-2), Flt-4(VEGFR-3), PDGFR-β and c-Kit(c-KIT) with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively. Axitinib is studied as an antitumor agent of various cell lines. Axitinib is an inhibitor of PDGFR-β.An inhibitor of Flt and Flk (VEGFR) with antitumor properties Axitinib is a non-selective receptor kinase inhibitor of Flt and Flk proteins. This compound also inhibits Flt-1(VEGFR-1), Flk-1(VEGFR-2), Flt-4(VEGFR-3), PDGFR-β and c-Kit(c-KIT) with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively. Axitinib is studied as an antitumor agent of various cell lines. Axitinib is an inhibitor of PDGFR-β. An inhibitor of Flt and Flk (VEGFR) with antitumor properties

名称和标识符

IUPAC Name	N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
INCHI	InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+
InChi Key	RITAVMQDGBJQJZ-FMIVXFBMSA-N
Canonical SMILES	CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4
分子式	C₂₂H₁₈N₄OS
PubChem CID	6450551
分子量	386.47

数据库链接

CAS Registry No.	319460-85-0
Wikipedia	Axitinib
DiscoveRx TREEspot	AG-013736\|
PubChem CID	6450551
DrugBank Ligand	DB06626
ChEMBL Ligand	CHEMBL1289926
RCSB PDB Ligand	AXI
PEP	axitinib
Reactome Reaction	R-HSA-9669854, R-HSA-9669900, R-HSA-9674430, R-HSA-9674095
Reactome Drug	R-ALL-9669719
DrugCentral Ligand	4225

化学和物理性质

溶解性	溶于DMSO, 最高浓度 (mg/mL): 9.66, 最高浓度(mM): 25

安全信息

象形图	Health Hazard Environmental Hazard Harmful
信号词	Warning
危险声明	H341: Suspected of causing genetic defects H373: Causes damage to organs through prolonged or repeated exposure H302: Harmful if swallowed H400: Very toxic to aquatic life H361: Suspected of damaging fertility or the unborn child
预防措施声明	P273,P280,P405,P501,P264,P260,P281,P270,P391,P330,P203,P301+P317,P318,P319
WGK Germany	3

靶标

Target ID

1813

名称

kinase insert domain receptor

缩写名

VEGFR-2

家族

Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family

别名

EBRT2

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	1	1356	4q12	KDR	kinase insert domain receptor
Mouse	1	1367	5 40.23 cM	Kdr	kinase insert domain protein receptor
Rat	1	1343	14p11	Kdr	kinase insert domain receptor

Ensembl Gene

ENSG00000128052 (Hs) , ENSMUSG00000062960 (Mm) , ENSRNOG00000046829 (Rn)

Entrez Gene

16542 (Mm) , 25589 (Rn) , 3791 (Hs)

OMIM

191306 (Hs)

Protein GI

11321597 (Hs) , 27777648 (Mm) , 6981128 (Rn)

UniProtKB

P35968 (Hs) , P35918 (Mm) , O08775 (Rn)

RefSeq Nucleotide

NM_002253 (Hs) , NM_010612 (Mm) , NM_013062 (Rn)

RefSeq Protein

NP_002244 (Hs) , NP_034742 (Mm) , NP_037194 (Rn)

Orphanet

229801 (Hs)

DrugBank Target

P35968 (Hs)

CATH/Gene3D

2.60.40.10 (N/A)

ChEMBL Target

CHEMBL3337 (Mm) , CHEMBL279 (Hs)

Target ID

2171

名称

polo like kinase 4

缩写名

PLK4

家族

Polo-like kinase (PLK) family

别名

Gpr41

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	2	970	4q28.1	PLK4	polo like kinase 4
Mouse	2	925	3 B	Plk4	polo like kinase 4
Rat	2	924	2q25	Plk4	polo-like kinase 4

Ensembl Gene

ENSG00000142731 (Hs) , ENSMUSG00000025758 (Mm) , ENSRNOG00000011654 (Rn)

Entrez Gene

10733 (Hs) , 20873 (Mm) , 310344 (Rn)

OMIM

605031 (Hs)

UniProtKB

B2GUY1 (Rn) , O00444 (Hs) , Q64702 (Mm)

RefSeq Nucleotide

NM_001107669 (Rn) , NM_001190799 (Hs) , NM_011495 (Mm)

RefSeq Protein

NP_001101139 (Rn) , NP_055079 (Hs) , NP_775261 (Mm)

Protein GI

121114283 (Hs) , 358438436 (Mm) , 157818171 (Rn)

CATH/Gene3D

3.30.1120.30 (N/A)

ChEMBL Target

CHEMBL3788 (Hs)

关联配体

Ligand ID	5659
名称	axitinib
别名	AG013736
类别	Synthetic organic
学名	N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Axitinib is a Type-1 kinase inhibitor. Axitinib inhibits several receptor tyrosine kinases including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT.