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阿格列汀

规格或纯度: ≥99%

CAS编号: 850649-61-5
分子式: C₁₈H₂₁N₅O₂
分子量: 339.39
PubChem编号: 11450633

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货号 (SKU)	包装规格	是否现货
A126201-10mg	10mg	现货
A126201-50mg	50mg	现货
A126201-250mg	250mg	现货
A126201-1g	1g	现货
A126201-5g	5g	现货
A126201-25g	25g	现货

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dipeptidyl peptidase 4 Inhibitor

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基本描述

规格或纯度	≥99%
英文名称	Alogliptin
别名	阿洛利停;阿格列汀
英文别名	SYR 322;2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile;Nesina;SYR-322;2-[[6-[(3R)-3-Amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]benzonitrile
生化机理


Alogliptin 的参考资料: [1]. Feng J, et al. Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV. J Med Chem. 2007 May 17;50(10):2297-300. [2]. Ta NN, et al. DPP-4 (CD26) inhibitor alogliptin inhibits TLR4-mediated ERK activation and ERK-dependent MMP-1 expression by U937 histiocytes. Atherosclerosis. 2010 Dec;213(2):429-35. [3]. Asakawa T, et al. A novel dipeptidyl peptidase-4 inhibitor, alogliptin (SYR-322), is effective in diabetic rats with sulfonylurea-induced secondary failure. Life Sci. 2009
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	10mg、50mg卖完停产，不再备货
产品介绍	Alogliptin是一种有效的，选择性的DPP-4抑制剂，IC50为<10 nM，比作用于DPP-8和DPP-9选择性高10000倍以上。 Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.

名称和标识符

IUPAC Name	2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile
INCHI	InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1
InChi Key	ZSBOMTDTBDDKMP-OAHLLOKOSA-N
Canonical SMILES	CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCCC(C3)N
分子式	C₁₈H₂₁N₅O₂
PubChem CID	11450633
分子量	339.39

数据库链接

PubChem CID	11450633
CAS Registry No.	850649-61-5
Wikipedia	Alogliptin
DrugBank Ligand	DB06203
ChEMBL Ligand	CHEMBL376359
RCSB PDB Ligand	T22
PEP	alogliptin
DrugCentral Ligand	4340

化学和物理性质

溶解性	25°C: DMSO 68 mg/mL; Water 2mg/m L; Ethanol <1 mg/mL

安全信息

象形图	Health Hazard Harmful
信号词	Warning
危险声明	H319: Causes serious eye irritation H351: Suspected of causing cancer
预防措施声明	P305+P351+P338,P280,P405,P501,P203,P264+P265,P318,P337+P317

靶标

Target ID

1612

名称

dipeptidyl peptidase 4

缩写名

SHP2

家族

S9: Prolyl oligopeptidase

别名

levocabastine-sensitive neurotensin receptor

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	1	766	2q24.2	DPP4	dipeptidyl peptidase 4
Mouse	1	760	2 35.85 cM	Dpp4	dipeptidylpeptidase 4
Rat	1	767	3q21	Dpp4	dipeptidylpeptidase 4

Ensembl Gene

ENSG00000197635 (Hs) , ENSMUSG00000035000 (Mm) , ENSRNOG00000030763 (Rn)

Entrez Gene

13482 (Mm) , 25253 (Rn) , 1803 (Hs)

OMIM

102720 (Hs)

Protein GI

6978773 (Rn) , 227116292 (Mm) , 18765694 (Hs)

UniProtKB

P27487 (Hs) , P28843 (Mm) , P14740 (Rn)

RefSeq Protein

NP_001926 (Hs) , NP_001153015 (Mm) , NP_034204 (Mm) , NP_036921 (Rn)

RefSeq Nucleotide

NM_001935 (Hs) , NM_001159543 (Mm) , NM_010074 (Mm) , NM_012789 (Rn)

MEROPS

S09.003 (Hs)

DrugBank Target

P27487 (Hs)

CATH/Gene3D

3.40.50.1820 (N/A)

ChEMBL Target

CHEMBL4653 (Rn) , CHEMBL284 (Hs) , CHEMBL3883 (Mm)

关联配体

Ligand ID	6319
名称	alogliptin
别名	Nesina®
类别	Synthetic organic
学名	2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)benzonitrile
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Alogliptin is a once-daily, oral dipeptidyl peptidase-4 (DPP-4) inhibitor class anti-diabetic drug.