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阿哌沙班

规格或纯度: ≥99%

CAS编号: 503612-47-3
分子式: C₂₅H₂₅N₅O₄
分子量: 459.51
EC号: 639-684-6
PubChem编号: 10182969

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货号 (SKU)	包装规格	是否现货
A126046-10mg	10mg	现货
A126046-50mg	50mg	现货
A126046-250mg	250mg	现货
A126046-1g	1g	现货
A126046-5g	5g	现货

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coagulation factor X Inhibitor

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基本描述

规格或纯度	≥99%
英文名称	Apixaban
别名	阿哌沙班
英文别名	BMS-562247-01; BMS 562247-01; BMS562247-01;1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
生化机理	Apixaban(BMS-562247-01; BMS 562247-01) is a direct factor Xa inhibitor with an IC50 of 0.22±0.02 μM. Apixaban is a compound being investigated as an anticoagulant. Apixaban (BMS-562247-01; BMS 562247-01)has similar affinity for human and rabbit factor Xa (FXa).
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Apixaban是一种高度选择性，可逆的凝血因子 Xa 抑制剂，抑制人和兔凝血因子 Xa 的 Ki 值分别为 0.08 nM 和 0.17 nM。Apixaban 正在开发用于预防和治疗各种血栓栓塞疾病。 Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively. Apixaban is in development for the prevention and treatment of various thromboembolic diseases.

名称和标识符

EC号	639-684-6
IUPAC Name	1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide
INCHI	InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)
InChi Key	QNZCBYKSOIHPEH-UHFFFAOYSA-N
Canonical SMILES	COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
分子式	C₂₅H₂₅N₅O₄
关联CAS	503612-47-3
UNII	3Z9Y7UWC1J
PubChem CID	10182969
分子量	459.51

数据库链接

PubChem CID	10182969
ChEMBL Ligand	CHEMBL231779
CAS Registry No.	503612-47-3
ChEBI	CHEBI:72296
DrugBank Ligand	DB06605
Wikipedia	Apixaban
RCSB PDB Ligand	GG2
PEP	apixaban
Reactome Reaction	R-HSA-9015122, R-HSA-9015111
Reactome Drug	R-ALL-9038732
DrugCentral Ligand	4298

化学和物理性质

溶解性	DMSO 18 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

安全信息

象形图	Health Hazard
信号词	Danger
危险声明	H373: Causes damage to organs through prolonged or repeated exposure H372: Causes damage to organs through prolonged or repeated exposure
预防措施声明	P501,P264,P260,P270,P319

靶标

Target ID

2359

名称

coagulation factor X

缩写名

SHP2

家族

S1: Chymotrypsin

别名

Y₁-like

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	2	488	13q34	F10	coagulation factor X
Mouse	2	481	8 5.73 cM	F10	coagulation factor X
Rat	2	482	16q12.5	F10	coagulation factor X

OMIM

613872 (Hs)

Entrez Gene

2159 (Hs) , 14058 (Mm) , 29243 (Rn)

UniProtKB

P00742 (Hs) , O88947 (Mm) , Q63207 (Rn)

RefSeq Protein

NP_000495 (Hs) , NP_031998 (Mm) , NP_058839 (Rn)

RefSeq Nucleotide

NM_000504 (Hs) , NM_007972 (Mm) , NM_017143 (Rn)

Ensembl Gene

ENSG00000126218 (Hs) , ENSMUSG00000031444 (Mm) , ENSRNOG00000033444 (Rn)

MEROPS

S01.216 (Hs)

Orphanet

121658 (Hs)

Protein GI

4503625 (Hs) , 110625994 (Mm) , 8393340 (Rn)

DrugBank Target

P00742 (Hs)

CATH/Gene3D

4.10.740.10 (N/A)

ChEMBL Target

CHEMBL3755 (Rn) , CHEMBL244 (Hs)

关联配体

Ligand ID	6390
名称	apixaban
别名	BMS-562247
类别	Synthetic organic
学名	1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Apixaban belongs to the direct factor Xa inhibitor family of drugs, which also includes and .