全反式视黄醛

规格或纯度: ≥98%

CAS编号: 116-31-4
分子式: C₂₀H₂₈O
分子量: 284.44
EC号: 204-135-8
MDL号: MFCD00001550
PubChem编号: 638015

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货号 (SKU)	包装规格	是否现货
A122355-50mg	50mg	现货
A122355-250mg	250mg	现货
A122355-1g	1g	现货
A122355-5g	5g	现货

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CNGA2 Gating inhibitor

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基本描述

规格或纯度	≥98%
英文名称	all trans-Retinal
别名	维生素 A 醛
英文别名	Vitamin A aldehyde
生化机理	All-trans retinal is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR) that act as transcription factors to regulate the growth and differentiation of normal and malignant cells. Retinal isomers are also chromophores that bind to opsins, a family of G-protein-linked transmembrane proteins, to form photosensitive receptors in visual and nonvisual systems. All-trans retinal is a potent photosensitizer.
应用	An oxidized form of retinol that is a corotenoid component of the visual pigments.All trans-Retinal has been used: · in optogenetic experiments · in electrophysiological experiment · to study the effect of AKR1B10 (aldo-keto reductase (AKR) superfamily member) on the conversion of retinal to retinol in the airway epithelium · in decidual transformation of human endometrial stromal cells
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	An oxidized form of retinol that is a corotenoid component of the visual pigments. Product Description： All trans-Retinal is one of the major derivatives of vitamin A group. A variety of food serves as a source of vitamin A. It is predominant in liver and among the brightly colored vegetables. An oxidized form of retinol that is a corotenoid component of the visual pigments.

名称和标识符

EC号	204-135-8
IUPAC Name	(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenal
INCHI	InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
InChi Key	NCYCYZXNIZJOKI-OVSJKPMPSA-N
Canonical SMILES	CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC=O)C)C
分子式	C₂₀H₂₈O
PubChem CID	638015
分子量	284.44

数据库链接

PubChem CID	638015
ChEMBL Ligand	CHEMBL81379
CAS Registry No.	116-31-4
ChEBI	CHEBI:17898
Wikipedia	Retinal
RCSB PDB Ligand	RET

化学和物理性质

溶解性	Soluble in Clear Yellow Solution at 5mg/ml Acetonitrile.
敏感性	对光线敏感
熔点	62-64 °C

安全信息

象形图	Health Hazard Harmful
信号词	Danger
危险声明	H315: Causes skin irritation H413: May cause long lasting harmful effects to aquatic life H302: Harmful if swallowed H360: May damage fertility or the unborn child
预防措施声明	P273,P280,P302+P352,P321,P405,P501,P264,P270,P362+P364,P330,P203,P301+P317,P318,P332+P317
WGK Germany	3

靶标

Target ID

395

名称

CNGA2

缩写名

SHP2

家族

Cyclic nucleotide-regulated channels (CNG)

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	6	664	Xq28	CNGA2	cyclic nucleotide gated channel subunit alpha 2
Rat	6	664	16q12.4	Cnga2	cyclic nucleotide gated channel subunit alpha 2
Mouse	6	664	X A7.3	Cnga2	cyclic nucleotide gated channel alpha 2

OMIM

300338 (Hs)

Entrez Gene

12789 (Mm) , 25411 (Rn) , 1260 (Hs)

UniProtKB

Q62398 (Mm) , Q00195 (Rn) , Q16280 (Hs)

RefSeq Protein

NP_005131 (Hs) , NP_037060 (Rn) , NP_031750 (Mm)

RefSeq Nucleotide

NM_005140 (Hs) , NM_012928 (Rn) , NM_007724 (Mm)

Ensembl Gene

ENSG00000183862 (Hs) , ENSMUSG00000005864 (Mm) , ENSRNOG00000030119 (Rn)

Protein GI

6978671 (Rn) , 42718011 (Hs) , 31982859 (Mm)

CATH/Gene3D

2.60.120.10 (N/A)

ChEMBL Target

CHEMBL4523272 (Rn)

关联配体

Ligand ID	2350
名称	all-trans-retinal
别名	all-trans-retinal
类别	Metabolite
学名	3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenal
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth.

参考文献

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