Cas(12279-41-3), 丝拉克肽-阿拉丁试剂, ,Adrenocorticotropic hormone fragment 1-39,

货号 (SKU)	包装规格	是否现货	价格	数量
A118746-1mg	1mg	现货
A118746-5mg	5mg	现货

基本描述

规格或纯度	≥97% (HPLC)
英文名称	Adrenocorticotropic hormone fragment 1-39
别名	Adrenocorticotropic Hormone human Corticotropin A ACTH(1-39),human
英文别名	Adrenocorticotropic Hormone human Corticotropin A ACTH(1-39),human
生化机理	Stimulates synthesis and secretion of glucocorticoids by adrenal cortex.Potent, endogenous melanocortin receptor 2 (MC 2 ) agonist (EC 50 = 57 pM). Component of the hypothalamo-pituitary-adrenal (HPA) stress axis with an important role in the pathogenesis of obesity and metabolic syndrome.
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	本产品以一种（或多种）包装尺寸提供，并进行冷冻干燥。因此，内含物可能会覆盖小瓶的底部或壁，因此可能不容易看到。请参阅我们的常见问题解答和信息页面以获取有关处理的更多详细信息。如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，这些产品最多可以使用一周。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	Amino Acid Sequence Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe Amino Acid Sequence Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe

名称和标识符

IUPAC Name	4-[2-[[2-[[2-[[2-[[2-[2-[[2-[[4-amino-2-[[1-[2-[[2-[[6-amino-2-[[2-[[1-[2-[[2-[[6-amino-2-[[6-amino-2-[[2-[[2-[[1-[6-amino-2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[(2-amino-3-hydroxypropanoyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]acetyl]amino]hexanoyl]amino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoyl]amino]acetyl]amino]propanoylamino]-4-carboxybutanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxypropanoyl]amino]propanoylamino]-5-[[1-[[1-[2-[[1-[[4-carboxy-1-[(1-carboxy-2-phenylethyl)amino]-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
INCHI	InChI=1S/C207H308N56O58S/c1-108(2)89-140(186(302)240-135(69-74-163(279)280)182(298)254-149(204(320)321)94-117-43-20-15-21-44-117)250-193(309)152-54-35-86-262(152)202(318)147(92-116-41-18-14-19-42-116)252-171(287)114(11)230-175(291)132(66-71-160(273)274)234-170(286)113(10)231-191(307)150(105-265)255-183(299)136(70-75-164(281)282)241-190(306)146(98-165(283)284)249-180(296)133(67-72-161(275)276)235-169(285)112(9)229-157(270)101-225-174(290)145(97-156(213)269)251-194(310)153-55-36-87-263(153)203(319)148(93-119-60-64-123(268)65-61-119)253-199(315)167(110(5)6)257-185(301)129(49-26-30-79-210)243-198(314)168(111(7)8)259-196(312)155-57-38-85-261(155)201(317)139(53-34-83-223-207(218)219)244-178(294)130(51-32-81-221-205(214)215)237-177(293)128(48-25-29-78-209)236-176(292)127(47-24-28-77-208)232-158(271)103-227-197(313)166(109(3)4)258-195(311)154-56-37-84-260(154)200(316)138(50-27-31-80-211)233-159(272)102-226-173(289)143(95-120-99-224-126-46-23-22-45-124(120)126)247-179(295)131(52-33-82-222-206(216)217)238-187(303)142(90-115-39-16-13-17-40-115)246-189(305)144(96-121-100-220-107-228-121)248-181(297)134(68-73-162(277)278)239-184(300)137(76-88-322-12)242-192(308)151(106-266)256-188(304)141(245-172(288)125(212)104-264)91-118-58-62-122(267)63-59-118/h13-23,39-46,58-65,99-100,107-114,125,127-155,166-168,224,264-268H,24-38,47-57,66-98,101-106,208-212H2,1-12H3,(H2,213,269)(H,220,228)(H,225,290)(H,226,289)(H,227,313)(H,229,270)(H,230,291)(H,231,307)(H,232,271)(H,233,272)(H,234,286)(H,235,285)(H,236,292)(H,237,293)(H,238,303)(H,239,300)(H,240,302)(H,241,306)(H,242,308)(H,243,314)(H,244,294)(H,245,288)(H,246,305)(H,247,295)(H,248,297)(H,249,296)(H,250,309)(H,251,310)(H,252,287)(H,253,315)(H,254,298)(H,255,299)(H,256,304)(H,257,301)(H,258,311)(H,259,312)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,320,321)(H4,214,215,221)(H4,216,217,222)(H4,218,219,223)
InChi Key	IDLFZVILOHSSID-UHFFFAOYSA-N
Canonical SMILES	CC(C)CC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C2CCCN2C(=O)C(CC3=CC=CC=C3)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CC(=O)N)NC(=O)C4CCCN4C(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(CCCCN)NC(=O)C(C(C)C)NC(=O)C6CCCN6C(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(C(C)C)NC(=O)C7CCCN7C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC8=CNC9=CC=CC=C98)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC1=CNC=N1)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CO)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C(CO)N
分子式	C₂₀₇H₃₀₈N₅₆O₅₈S
PubChem CID	90488848
分子量	4541.07

安全信息

象形图	Health Hazard Harmful
信号词	Warning
危险声明	H351: Suspected of causing cancer H302: Harmful if swallowed H312: Harmful in contact with skin H332: Harmful if inhaled
预防措施声明	P261,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P362+P364,P330,P203,P301+P317,P318,P317
WGK Germany	3
个人防护装备	Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

靶标

Target ID

283

名称

MC₂ receptor

缩写名

SHP2

家族

Melanocortin receptors

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	296	18p12.1	Mc2r	melanocortin 2 receptor
Human	7	297	18p11.2	MC2R	melanocortin 2 receptor
Mouse	7	296	18 41.89 cM	Mc2r	melanocortin 2 receptor

RefSeq Protein

NP_001093961 (Rn) , NP_000520 (Hs) , NP_032586 (Mm)

UniProtKB

Q01718 (Hs) , Q64326 (Mm)

OMIM

607397 (Hs)

RefSeq Nucleotide

NM_000529 (Hs) , NM_001100491 (Rn) , NM_008560 (Mm)

Entrez Gene

4158 (Hs) , 282839 (Rn) , 17200 (Mm)

Ensembl Gene

ENSG00000185231 (Hs) , ENSMUSG00000045569 (Mm) , ENSRNOG00000016681 (Rn)

Orphanet

123161 (Hs)

Protein GI

6678820 (Mm) , 281371364 (Rn) , 4505127 (Hs)

GPCRdb

acthr_human (Hs) , acthr_mouse (Mm)

UniProtKB ID/Entry name

ACTHR_HUMAN (Hs) , ACTHR_MOUSE (Mm)

DrugBank Target

Q01718 (Hs)

ChEMBL Target

CHEMBL2279 (Mm) , CHEMBL1965 (Hs)

关联配体

Ligand ID

1331

名称

ACTH

别名

adrenocorticotropic hormone (1-39)

类别

Peptide

学名

4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide

生物活性评价

The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).

评价

Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth.

配体家族

Neuropeptides

基因/前体

Gene symbol	Gene name	Precursor protein name	Species	别名
Pomc	pro-opiomelanocortin-alpha	pro-opiomelanocortin	Mouse	POMC, Pomc-1, ACTH, adrenal corticotropic hormone, alpha-melanocyte stimulating hormone, alpha-MSH, beta-MSH, gamma-MSH, beta-melanocyte stimulating hormone, gamma-melanocyte stimulating hormone, alphaMSH, beta-endorphin, BE
Pomc	proopiomelanocortin	pro-opiomelanocortin	Rat	Pomc1, Pomc2, alphaMSH, alpha-melanocyte-stimulating hormone, corticotropin-lipotropin, pro-opiomelanocortin, pro-opiomelanocortin-alpha, proopiomelanocortin, proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin), proopiomelanocortin, beta (endorphin, beta), proopoimelanocortin, beta (endorphin, beta)

单字母多肽序列

SYSMEHFRWGKPVGKKRRPVKVYPNVAENESAEAFPLEF

三字母多肽序列

Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Val-Ala-Glu-Asn-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe

翻译后修饰

None.

化学修饰

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丝拉克肽

库存信息

库存信息

基本描述

名称和标识符

安全信息

靶标

关联配体

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丝拉克肽

库存信息

库存信息

基本描述

名称和标识符

安全信息

靶标

关联配体

相关文档

质检报告COA

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