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二苯基硼酸-2-氨基乙酯

Ca 2+释放调节剂
规格或纯度: 98%
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
A106408-1g
 1g 期货 Stock Image
A106408-5g
 5g 期货 Stock Image
A106408-10g
 10g 期货 Stock Image
A106408-25g
 25g 期货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
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TRPC1 Channel blocker TRPC2 Channel blocker TRPC3 Channel blocker TRPC4 Channel blocker TRPC5 Channel blocker TRPC6 Channel blocker TRPC7 Channel blocker TRPM2 Channel blocker TRPM3 Gating inhibitor TRPM6 Activator TRPM7 Activator TRPM7 Channel blocker TRPM8 Channel blocker TRPV1 Activator TRPV1 Channel blocker TRPV2 Activator TRPV3 Activator TRPV6 Activator
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基本描述

规格或纯度 98%
英文名称 2-Aminoethyl diphenylborinate
别名 二苯基硼酸
英文别名 524-95-8|2-Aminoethyl diphenylborinate|2-APB|(2-Aminoethoxy)diphenylborane|2-Aminoethoxydiphenylborane|2-((Diphenylboryl)oxy)ethanamine|2-aminoethoxydiphenyl borate|2-Aminoethoxydiphenylborate|2-diphenylboranyloxyethanamine|Borinic acid, diphenyl-, 2-amin
生化机理 D-肌醇1,4,5-三磷酸（IP3）的细胞渗透性变构抑制剂可诱导Ca 2+释放。抑制IP3诱导的Ca 2+释放，而不影响IP3受体结合。阻止存储操作的Ca 2+入口。
应用 用于黄酮类化合物的密度测定。膜渗透调控因子，调控细胞间IP3诱导的钙离子释放。
储存温度 -20°C储存,充氩
运输条件 超低温冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

2-APB is a transient receptor potential (TRP) activator. The compound also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca2+-ATPase pumps, and native store operated channels, as well as other ion channels. 2-APB does not activate the subfamily transient receptor potential vanilloids (TRPVs) TRPV4, TRPV5, and TRPV6, but can activate VR1 (TRPV1), VRL-1 (TRPV2), and TRPV3. 2-ABP was first used as an inhibitor of IP3R (inositol 1,4,5-triphosphate receptor) with the ability to permeate the membrane. 2-ABP can induce Ca2+entry without activating exocytosis. In pancreatic acinar cells 2-ABP can inhibit calcium mobilization. 2-APB is an activator of Orai3.用于黄酮类化合物的密度测定。膜渗透调控因子，调控细胞间IP3诱导的钙离子释放。

2-APB is a transient receptor potential (TRP) activator. The compound also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca2+-ATPase pumps, and native store operated channels, as well as other ion channels. 2-APB does not activate the subfamily transient receptor potential vanilloids (TRPVs) TRPV4, TRPV5, and TRPV6, but can activate VR1 (TRPV1), VRL-1 (TRPV2), and TRPV3. 2-ABP was first used as an inhibitor of IP3R (inositol 1,4,5-triphosphate receptor) with the ability to permeate the membrane. 2-ABP can induce Ca2+entry without activating exocytosis. In pancreatic acinar cells 2-ABP can inhibit calcium mobilization. 2-APB is an activator of Orai3.

名称和标识符

EC号 208-366-5
IUPAC Name 2-diphenylboranyloxyethanamine
INCHI InChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChi Key BLZVCIGGICSWIG-UHFFFAOYSA-N
Canonical SMILES B(C1=CC=CC=C1)(C2=CC=CC=C2)OCCN
WGK Germany 3
RTECS ED6150000
PubChem CID 1598
分子量 225.09
Beilstein号 2942273
Reaxy-Rn 2942273

化学和物理性质

溶解性 可溶于甲醇
密度 1.04
敏感性 光及湿度敏感
熔点 190-194°C

安全和危险性（GHS）

象形图
ghs07

Harmful
信号词 Warning
危险声明 H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
预防措施声明 P261,P305+P351+P338,P280,P302+P352,P405,P501,P264,P271,P304+P340,P337+P313,P403+P233,P332+P313
WGK Germany 3
RTECS ED6150000
Reaxy-Rn 2942273
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

关联配体

Ligand ID 2433
名称 2-APB
别名 2-APB
类别 Synthetic organic
学名 2-di(phenyl)boranyloxyethanamine
生物活性评价 The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价 Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth.

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参考文献

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11. Kubota H et al..  (2014)  mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways..  PLoS One,  9  (9):  (e106316).  [PMID:25181481]
12. Li C et al..  (2022)  PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity..  Front Cell Dev Biol,  10  ():  (896014).  [PMID:35874841]
13. Bai D et al..  (2020)  Porcine deltacoronavirus (PDCoV) modulates calcium influx to favor viral replication..  Virology,  539  ():  (38-48).  [PMID:31670218]
14. Heeley N et al..  (2018)  Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights..  Mol Metab,  10  ():  (14-27).  [PMID:29439854]
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16. Li L et al..  (2020)  TRPM7 modulates macrophage polarization by STAT1/STAT6 pathways in RAW264.7\xa0cells..  Biochem Biophys Res Commun,  533  (4):  (692-697).  [PMID:33153718]
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