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长春新碱 硫酸酯

规格或纯度: 符合USP测试规范
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
V432299-1mg
1mg 期货 Stock Image
V432299-5mg
5mg 期货 Stock Image
V432299-25mg
25mg 期货 Stock Image

基本描述

别名 长春新碱 硫酸盐, VCR, 长春醛碱 硫酸盐, 醛基长春碱 硫酸盐
规格或纯度 符合USP测试规范
英文名称 Vincristine sulfate
生化机理 Vincristine sulfate possesses antitumor action targeting cell cycle. It prevents the action of tubulin by inhibiting microtubule polymerization. It also causes cell death and blocks metaphase in mitosis by preventing chromosome segregation. Vincristine sulfate inhibits angiogenesis mediated by factors such as vasculature endothelial growth factor. It decreases vascularization in tumors and normal tissues.
储存温度 -20°C储存
运输条件 超低温冰袋运输
产品介绍

应用

Vincristine sulfate has been used: as a positive control in potato disc anti-tumor bioassay as a standard cytotoxic agent to treat cells for manipulation of the microtubule network use product name over-ride for USP name - jk 6/2/2005

General Description

Vincristine sulfate is an alkaloid present in Cantharanthus roseus .


Application

Vincristine sulfate has been used: as a positive control in potato disc anti-tumor bioassay as a standard cytotoxic agent to treat cells for manipulation of the microtubule network

名称和标识符

EC号 218-190-0
IUPAC Name methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid
INCHI InChI=1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1
InChi Key AQTQHPDCURKLKT-JKDPCDLQSA-N
Canonical SMILES CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O
关联CAS 57-22-7(free base)
PubChem CID 249332
UN Number 1544
Packing Group I
分子量 923.04
Beilstein号 3924631

化学和物理性质

熔点 300 °C

安全和危险性(GHS)

象形图
ghs06

Toxic

ghs08

Health Hazard

信号词 Danger
危险声明 H341: Suspected of causing genetic defects
H300: Fatal if swallowed
H361: Suspected of damaging fertility or the unborn child
预防措施声明 P280,P321,P405,P501,P264,P281,P270,P330,P203,P301+P316,P318
Class 6.1
Merck Index 9986

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参考文献

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