| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| V140453-250mg | 250mg |
现货  |
| |
| V140453-1g | 1g |
现货 |
| |
| V140453-5g | 5g |
现货 |
|
| 英文名称 | Vitamin K2 |
|---|---|
| 别名 | 甲萘醌 4；四烯甲萘醌；2-甲基-3-[(2E,6E,10E)-3,7,11,15-四甲基十六碳-2,6,10,14-四烯-1-基]萘-1,4-二酮 |
| 英文别名 | Menatetrenone; Menaquinone 4 |
| 生化机理 | Menatetrenone (MK-4) is one of nine forms of vitamin K2 which is ubiquitously present in extrahepatic tissues. MK-4 has a number of metabolic and anti-neoplastic activities. |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| IUPAC Name | 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]naphthalene-1,4-dione |
|---|---|
| INCHI | InChI=1S/C31H40O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,12,14,16,18-20H,9-11,13,15,17,21H2,1-6H3/b23-14+,24-16+,25-20+ |
| InChi Key | DKHGMERMDICWDU-GHDNBGIDSA-N |
| Canonical SMILES | CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C |
| 分子式 |
C31H40O2 |
| 关联CAS | 11032-49-8 |
| PubChem CID | 5282367 |
| 分子量 | 444.65 |
| 溶解性 | Soluble in diethyl ether, chloroform, and hexane. Insoluble in water. |
|---|---|
| 密度 | 1 |
| 沸点 | 570.6° C |
| 熔点 | 227.73°C |
| 折光率 | 1.54 |
| WGK Germany | 3 |
|---|---|
| RTECS | QL9279500 |
| 个人防护装备 | Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter |
| 1. Norio Iinuma. (2005-06-03) [Vitamin K2 (menatetrenone) and bone quality].. Clinical calcium, 15 ((6)): (1034-1039). [PMID:15930719] |
| 2. Takayuki Hosoi. (2007-11-06) [Treatment of primary osteoporosis with vitamin K2].. Clinical calcium, 17 ((11)): (1727-1730). [PMID:17982193] |
| 3. Yoshitomo Suhara,Yoshihisa Hirota,Kimie Nakagawa,Maya Kamao,Naoko Tsugawa,Toshio Okano. (2008-01-04) Design and synthesis of biologically active analogues of vitamin K2: evaluation of their biological activities with cultured human cell lines.. Bioorganic & medicinal chemistry, 16 ((6)): (3108-3117). [PMID:18171617] |
| 4. Jun Iwamoto,Hideo Matsumoto,Tsuyoshi Takeda. (2009-06-09) Efficacy of menatetrenone (vitamin K2) against non-vertebral and hip fractures in patients with neurological diseases: meta-analysis of three randomized, controlled trials.. Clinical drug investigation, 29 ((7)): (471-479). [PMID:19499964] |
| 5. Jun Iwamoto,Hideo Matsumoto,Tsuyoshi Takeda,Yoshihiro Sato,James K Yeh. (2010-06-18) Effects of vitamin K2 on cortical and cancellous bone mass, cortical osteocyte and lacunar system, and porosity in sciatic neurectomized rats.. Calcified tissue international, 87 ((3)): (254-262). [PMID:20556371] |
| 6. Mariko Ochiai,Ayumu Nakashima,Norihisa Takasugi,Kei Kiribayashi,Toru Kawai,Koji Usui,Kenichiro Shigemoto,Naoki Hamaguchi,Nobuoki Kohno,Noriaki Yorioka. (2010-08-07) Vitamin K? alters bone metabolism markers in hemodialysis patients with a low serum parathyroid hormone level.. Nephron. Clinical practice, 117 ((1)): (c15-c19). [PMID:20689320] |
| 7. Yoshihiro Sato. (2010-09-03) [Dementia and fracture].. Clinical calcium, 20 ((9)): (1379-1384). [PMID:20808046] |
| 8. Kimie Nakagawa,Yoshihisa Hirota,Natsumi Sawada,Naohito Yuge,Masato Watanabe,Yuri Uchino,Naoko Okuda,Yuka Shimomura,Yoshitomo Suhara,Toshio Okano. (2010-10-19) Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme.. Nature, 468 ((7320)): (117-121). [PMID:20953171] |
| 9. Hao Zhang,Iwata Ozaki,Hiroshi Hamajima,Shinji Iwane,Hirokazu Takahashi,Yasunori Kawaguchi,Yuichiro Eguchi,Kyosuke Yamamoto,Toshihiko Mizuta. (2010-11-27) Vitamin K2 augments 5-fluorouracil-induced growth inhibition of human hepatocellular carcinoma cells by inhibiting NF-κB activation.. Oncology reports, 25 ((1)): (159-166). [PMID:21109972] |
| 10. T Terachi,Y Inoue,N Ashihara,M Kobayashi,K Ando,T Matsui. (2010-12-21) Plasma vitamin K concentration in horses supplemented with several vitamin K homologs.. Journal of animal science, 89 ((4)): (1056-1061). [PMID:21169510] |
| 11. Kazuo Kojima,Masaya Tamano,Takashi Akima,Takashi Hashimoto,Toru Kuniyoshi,Chizu Maeda,Yuichi Majima,Koji Kusano,Toshimitu Murohisa,Makoto Iijima,Hideyuki Hiraishi. (2011-03-18) Effect of vitamin K2 on the development of hepatocellular carcinoma in type C cirrhosis.. Hepato-gastroenterology, 57 ((102-103)): (1264-1267). [PMID:21410069] |
| 12. Gilbert R Kaats,Harry G Preuss,Harry A Croft,Samuel C Keith,Patti L Keith. (2011-03-31) A comparative effectiveness study of bone density changes in women over 40 following three bone health plans containing variations of the same novel plant-sourced calcium.. International journal of medical sciences, 8 ((3)): (180-191). [PMID:21448303] |
| 13. I H Baek,W Kang,H Y Yun,S S Lee,K I Kwon. (2011-05-07) Modelling the atypical absorption of menatetrenone and the metabolism to its epoxide: effect of VKORC1 polymorphism.. Journal of clinical pharmacy and therapeutics, 36 ((3)): (390-398). [PMID:21545618] |
| 14. Yoshitomo Suhara,Masato Watanabe,Kimie Nakagawa,Akimori Wada,Yoichi Ito,Kazuyoshi Takeda,Kazuhiko Takahashi,Toshio Okano. (2011-05-13) Synthesis of novel vitamin K2 analogues with modification at the ω-terminal position and their biological evaluation as potent steroid and xenobiotic receptor (SXR) agonists.. Journal of medicinal chemistry, 54 ((12)): (4269-4273). [PMID:21561094] |
| 15. Yoshitomo Suhara,Masato Watanabe,Sayaka Motoyoshi,Kimie Nakagawa,Akimori Wada,Kazuyoshi Takeda,Kazuhiko Takahashi,Hiroaki Tokiwa,Toshio Okano. (2011-05-31) Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: insights into the biological role of the side chain part of vitamin K.. Journal of medicinal chemistry, 54 ((13)): (4918-4922). [PMID:21618996] |
| 16. Akihiko Tsuchida,Takao Itoi,Kazuhiko Kasuya,Yuichi Nagakawa,Minako Suzuki,Takahisa Ikeda,Yoshiaki Suzuki,Tatsuya Aoki,Keisuke Miyazawa. (2011-06-15) Chemoprevention of chemically-induced biliary carcinogenesis in hamsters by vitamin K2.. Hepato-gastroenterology, 58 ((106)): (290-297). [PMID:21661384] |
| 17. Yoshihiro Sato,Yoshiaki Honda,Kazuo Umeno,Norimasa Hayashida,Jun Iwamoto,Tsuyoshi Takeda,Hideo Matsumoto. (2011-07-23) The prevention of hip fracture with menatetrenone and risedronate plus calcium supplementation in elderly patients with Alzheimer disease: a randomized controlled trial.. The Kurume medical journal, 57 ((4)): (117-124). [PMID:21778673] |
| 18. Sherry M Farley,Scott W Leonard,Edwin M Labut,Hannah F Raines,David J Card,Dominic J Harrington,Debbie J Mustacich,Maret G Traber. (2012-06-19) Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone.. Molecular nutrition & food research, 56 ((6)): (912-922). [PMID:22707266] |
| 19. Pornpimol Rianthavorn,Kantima Pisutikul,Tawatchai Deekajorndech,Supatporn Tepmongkol,Kanya Suphapeetiporn. (2012-07-10) Prevention of bone loss in children receiving long-term glucocorticoids with calcium and alfacalcidol or menatetrenone.. Journal of pediatric endocrinology & metabolism : JPEM, 25 ((3-4)): (307-312). [PMID:22768661] |
| 20. Jun Iwamoto,Yoshihiro Sato. (2013-01-26) Menatetrenone for the treatment of osteoporosis.. Expert opinion on pharmacotherapy, 14 ((4)): (449-458). [PMID:23346882] |
| 21. Fumiaki Hanzawa,Saki Nomura,Eri Sakuma,Tomono Uchida,Saiko Ikeda. (2013-05-24) Dietary sesame seed and its lignan, sesamin, increase tocopherol and phylloquinone concentrations in male rats.. The Journal of nutrition, 143 ((7)): (1067-1073). [PMID:23700348] |
| 22. Yoshihisa Hirota,Naoko Tsugawa,Kimie Nakagawa,Yoshitomo Suhara,Kiyoshi Tanaka,Yuri Uchino,Atsuko Takeuchi,Natsumi Sawada,Maya Kamao,Akimori Wada,Takashi Okitsu,Toshio Okano. (2013-10-03) Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats.. The Journal of biological chemistry, 288 ((46)): (33071-33080). [PMID:24085302] |
| 23. Katheryne Z Edson,Bhagwat Prasad,Jashvant D Unadkat,Yoshitomo Suhara,Toshio Okano,F Peter Guengerich,Allan E Rettie. (2013-10-22) Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11.. Biochemistry, 52 ((46)): (8276-8285). [PMID:24138531] |
| 24. Tomohiro Shimizu,Masahiko Takahata,Yusuke Kameda,Hiroki Hamano,Teppei Ito,Hiromi Kimura-Suda,Masahiro Todoh,Shigeru Tadano,Norimasa Iwasaki. (2014-04-16) Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair.. Bone, 64 (): (95-101). [PMID:24731926] |
| 25. Y F Liao,Y Wang,Y Huang,S F Zha,J J Liu,Z K Wang,Y P Yin,Y F Liao,Y Wang. (2015-03-17) ISOLATION AND FUNCTIONAL ANALYSIS OF McMenA, A GENE ENCODING A 1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE IN Mylabris cichorii.. Archives of insect biochemistry and physiology, 89 ((3)): (127-137). [PMID:25772016] |
| 26. Pinkesh G Sutariya,Alok Pandya,Anand Lodha,Shobhana K Menon. (2015-11-26) A simple and rapid creatinine sensing via DLS selectivity, using calix[4]arene thiol functionalized gold nanoparticles.. Talanta, 147 (): (590-597). [PMID:26592650] |
| 27. Sarah Nicolai,Marcin Wegrecki,Tan-Yun Cheng,Elvire A Bourgeois,Rachel N Cotton,Jacob A Mayfield,Gwenna?lle C Monnot,Jér?me Le Nours,Ildiko Van Rhijn,Jamie Rossjohn,D Branch Moody,Annemieke de Jong. (2020-01-05) Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.. Science immunology, 5 ((43)): (). [PMID:31901073] |
| 28. Dong-Jae Jun,Marc M Schumacher,Seonghwan Hwang,Lisa N Kinch,Nick V Grishin,Russell A DeBose-Boyd. (2020-03-20) Schnyder corneal dystrophy-associated UBIAD1 is defective in MK-4 synthesis and resists autophagy-mediated degradation.. Journal of lipid research, 61 ((5)): (746-757). [PMID:32188638] |
| 29. Cathrine Arnason B?e,Helge Holo. (2020-04-08) Engineering Lactococcus lactis for Increased Vitamin K2 Production.. Frontiers in bioengineering and biotechnology, 8 (): (191-191). [PMID:32258010] |
| 30. Fengsen Duan,Chunlei Mei,Luhao Yang,Junyan Zheng,Huiai Lu,Yanzhi Xia,Stacy Hsu,Huageng Liang,Ling Hong. (2020-05-10) Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells.. Scientific reports, 10 ((1)): (7714-7714). [PMID:32382009] |
| 31. Jonna Weisell,Anna-Kaisa Ruotsalainen,Juha N?p?nkangas,Matti Jauhiainen,Jaana Rys?. (2021-02-06) Menaquinone 4 increases plasma lipid levels in hypercholesterolemic mice.. Scientific reports, 11 ((1)): (3014-3014). [PMID:33542347] |
| 32. Hans B Smith,Tin Lok Li,Man Kit Liao,Grischa Y Chen,Zhihong Guo,John-Demian Sauer. (2021-02-24) Listeria monocytogenes MenI Encodes a DHNA-CoA Thioesterase Necessary for Menaquinone Biosynthesis, Cytosolic Survival, and Virulence.. Infection and immunity, 89 ((5)): (). [PMID:33619030] |
| 33. Xi Gu,Ing-Gin Chen,Scott A Harding,Batbayar Nyamdari,Maria A Ortega,Kristen Clermont,James H Westwood,Chung-Jui Tsai. (2021-04-02) Plasma membrane phylloquinone biosynthesis in nonphotosynthetic parasitic plants.. Plant physiology, 185 ((4)): (1443-1456). [PMID:33793953] |
| 34. Natsuko Sogabe,Rieko Maruyama,Otto Baba,Takayuki Hosoi,Masae Goseki-Sone. (2011-02-08) Effects of long-term vitamin K(1) (phylloquinone) or vitamin K(2) (menaquinone-4) supplementation on body composition and serum parameters in rats.. Bone, 48 ((5)): (1036-1042). [PMID:21295170] |
| 35. Thawee Songpatanasilp,La-or Chailurkit,Suwannee Chantprasertyothin,Boonsong Ongphiphadhanakul,Nimit Taechakraichana. (2011-02-24) Effect of GGCX gene polymorphism on the responses of serum undercarboxylated osteocalcin and bone turnover markers after treatment with vitamin K2 (menatetrenone) among postmenopausal Thai women.. Journal of bone and mineral metabolism, 29 ((5)): (606-614). [PMID:21344298] |
| 36. Makoto Otsuka,Ryuhei Hirano. (2011-04-05) Bone cell activity responsive drug release from biodegradable apatite/collagen nano-composite cements--in vitro dissolution medium responsive vitamin K2 release.. Colloids and surfaces. B, Biointerfaces, 85 ((2)): (338-342). [PMID:21458964] |
| 37. Asagi Ito,Hitoshi Shirakawa,Naofumi Takumi,Yoshihiko Minegishi,Ai Ohashi,Zakir H Howlader,Yusuke Ohsaki,Toshiro Sato,Tomoko Goto,Michio Komai. (2011-09-15) Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells.. Lipids in health and disease, 10 (): (158-158). [PMID:21914161] |
| 38. Yoshitomo Suhara,Norika Hanada,Takashi Okitsu,Miho Sakai,Masato Watanabe,Kimie Nakagawa,Akimori Wada,Kazuyoshi Takeda,Kazuhiko Takahashi,Hiroaki Tokiwa,Toshio Okano. (2012-01-19) Structure-activity relationship of novel menaquinone-4 analogues: modification of the side chain affects their biological activities.. Journal of medicinal chemistry, 55 ((4)): (1553-1558). [PMID:22250752] |
| 39. Ala Al Rajabi,Sarah L Booth,James W Peterson,Sang Woon Choi,John W Suttie,M Kyla Shea,Benchun Miao,Michael A Grusak,Xueyan Fu. (2012-03-23) Deuterium-labeled phylloquinone has tissue-specific conversion to menaquinone-4 among Fischer 344 male rats.. The Journal of nutrition, 142 ((5)): (841-845). [PMID:22437559] |
| 40. Toshiro Sato,Leon J Schurgers,Kazuhiro Uenishi. (2012-11-13) Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women.. Nutrition journal, 11 (): (93-93). [PMID:23140417] |
| 41. Michael L Nickerson,Allen D Bosley,Jayne S Weiss,Brittany N Kostiha,Yoshihisa Hirota,Wolfgang Brandt,Dominic Esposito,Shigeru Kinoshita,Ludger Wessjohann,Scott G Morham,Thorkell Andresson,Howard S Kruth,Toshio Okano,Michael Dean. (2012-11-22) The UBIAD1 prenyltransferase links menaquinone-4 [corrected] synthesis to cholesterol metabolic enzymes.. Human mutation, 34 ((2)): (317-329). [PMID:23169578] |
| 42. Mitsuru Ishizuka,Keiichi Kubota,Mitsugi Shimoda,Junji Kita,Masato Kato,Kyung Hwa Park,Takayuki Shiraki. (2012-12-12) Effect of menatetrenone, a vitamin k2 analog, on recurrence of hepatocellular carcinoma after surgical resection: a prospective randomized controlled trial.. Anticancer research, 32 ((12)): (5415-5420). [PMID:23225445] |
| 43. Carla A F Portela,Kathleen F Smart,Sergey Tumanov,Gregory M Cook,Silas G Villas-B?as. (2014-03-25) Global metabolic response of Enterococcus faecalis to oxygen.. Journal of bacteriology, 196 ((11)): (2012-2022). [PMID:24659768] |
| 44. Wei-Jie Wu,Hwa-Young Lee,Geum-Hwa Lee,Han-Jung Chae,Byung-Yong Ahn. (2014-09-27) The antiosteoporotic effects of Cheonggukjang containing vitamin k2 (menaquinone-7) in ovariectomized rats.. Journal of medicinal food, 17 ((12)): (1298-1305). [PMID:25259841] |
| 45. Erin D Lew,Jennifer Oh,Patrick G Burrola,Irit Lax,Anna Zagórska,Paqui G Través,Joseph Schlessinger,Greg Lemke. (2014-09-30) Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities.. eLife, 3 (): (). [PMID:25265470] |
| 46. Lei Wang,Sebastian S DeMarco,JianMing Chen,Charles M Phillips,Lance C Bridges. (2015-04-01) Retinoids Bias Integrin Expression and Function in Cutaneous T-Cell Lymphoma.. The Journal of investigative dermatology, 135 ((8)): (2102-2108). [PMID:25826424] |
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