Cas(83480-29-9), 伏格列波糖-阿拉丁试剂, ,Voglibose,

货号 (SKU)	包装规格	是否现货
V121714-50mg	50mg	现货
V121714-100mg	100mg	现货
V121714-500mg	500mg	现货

基本描述

规格或纯度	98%
英文名称	Voglibose
别名	伏格列波糖
英文别名	3,4-Dideoxy-4-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-D-epi-inositol N-(1,3-Dihydroxyprop-2-yl)valiolamine;3,4-Dideoxy-4-{2-hydroxy-1-(hydroxymethyl)ethylamino-2-D-epi-inositol, N-(1,3-Dihydroxyprop-2-yl)valiolamine
生化机理	口服有效α-葡萄糖苷酶抑制剂（蔗糖酶和麦芽糖酶的IC50值分别为3.9和6.4 nM）。在Wistar肥胖大鼠中增加胰高血糖素样肽1（GLP-1）的分泌并减少食物摄入量，并降低血浆葡萄糖，甘油三酸酯和胰岛素的浓度。在体内表现出抗糖尿病和抗肥胖活性。
应用	伏格列波糖是一种α-葡萄糖苷酶抑制剂,与阿卡波糖(acarbose)，米格列醇(miglitol)类似，用于降低糖尿病人餐后高血糖（PPHG）。伏格列波糖是用来作为胰高血糖素样肽受体和磷酸肌醇3 - 激酶Akt内皮型一氧化氮合酶路径对缺血再灌注损伤的一种保护剂.
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	伏格列波糖是一种α-葡萄糖苷酶抑制剂,与阿卡波糖(acarbose)，米格列醇(miglitol)类似，用于降低糖尿病人餐后高血糖（PPHG）。伏格列波糖是用来作为胰高血糖素样肽受体和磷酸肌醇3 - 激酶Akt内皮型一氧化氮合酶路径对缺血再灌注损伤的一种保护剂. Voglibose is an α-glucosidase inhibitor, similar to acarbose and miglitol, used for lowering post-prandial hyperglycemia (PPHG) in people with diabetes mellitus. Voglibose is used to study it benefits as a protectant against ischemia-reperfusion injury through glucagon-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway. Voglibose is an α-glucosidase inhibitor, similar to acarbose and miglitol, used for lowering post-prandial hyperglycemia (PPHG) in people with diabetes mellitus. Voglibose is used to study it benefits as a protectant against ischemia-reperfusion injury through glucagon-like peptide receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway.

名称和标识符

IUPAC Name	(1S,2S,3R,4S,5S)-5-(1,3-dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol
INCHI	InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m0/s1
InChi Key	FZNCGRZWXLXZSZ-CIQUZCHMSA-N
Canonical SMILES	C1C(C(C(C(C1(CO)O)O)O)O)NC(CO)CO
分子式	C₁₀H₂₁NO₇
PubChem CID	444020
分子量	267.28

化学和物理性质

溶解性	溶于water, 最高浓度 (mg/mL): 26.73, 最高浓度(mM): 100；溶于DMSO, 最高浓度 (mg/mL): 20.05, 最高浓度(mM): 75
敏感性	对热敏感
熔点	165°C
比旋光度	46°(C=1,0.1mol/L HCL)

安全信息

WGK Germany	3
RTECS	NM7524600
Reaxy-Rn	5430708
Merck Index	10029

参考文献

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3. Ryuzo Kawamori. (2010-05-08) [Voglibose for the prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese subjects with impaired glucose tolerance].. Nihon rinsho. Japanese journal of clinical medicine, 68 ((5)): (873-881). [PMID:20446586]
4. Y Iwamoto,A Kashiwagi,N Yamada,S Terao,N Mimori,M Suzuki,H Tachibana. (2010-07-02) Efficacy and safety of vildagliptin and voglibose in Japanese patients with type 2 diabetes: a 12-week, randomized, double-blind, active-controlled study.. Diabetes, obesity & metabolism, 12 ((8)): (700-708). [PMID:20590747]
5. Yasuhiro Shimojima,Wataru Ishii,Masayuki Matsuda,Kana Tojo,Rie Watanabe,Shu-Ichi Ikeda. (2011-01-18) Pneumatosis cystoides intestinalis in neuropsychiatric systemic lupus erythematosus with diabetes mellitus: case report and literature review.. Modern rheumatology, 21 ((4)): (415-419). [PMID:21240619]
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7. Michio Shimabukuro,Hiroaki Masuzaki,Masataka Sata. (2012-02-02) Intensive glucose lowering in cardiovascular risk management - unsolved questions - .. Circulation journal : official journal of the Japanese Circulation Society, 76 ((3)): (593-595). [PMID:22293455]
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18. Hiroki Oe,Kazufumi Nakamura,Hajime Kihara,Kenei Shimada,Shota Fukuda,Tsutomu Takagi,Toru Miyoshi,Kumiko Hirata,Junichi Yoshikawa,Hiroshi Ito. (2015-06-19) Comparison of effects of sitagliptin and voglibose on left ventricular diastolic dysfunction in patients with type 2 diabetes: results of the 3D trial.. Cardiovascular diabetology, 14 (): (83-83). [PMID:26084668]
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21. Xiaodan Liu,Jianan Feng,Yan Li. (2018-03-05) Preparation of carbon-functionalized magnetic graphene/mesoporous silica composites for selective extraction of miglitol and voglibose in rat plasma.. Talanta, 182 (): (405-413). [PMID:29501171]
22. Kemin Tan,Christine Tesar,Rosemarie Wilton,Robert P Jedrzejczak,Andrzej Joachimiak. (2018-05-16) Interaction of antidiabetic α-glucosidase inhibitors and gut bacteria α-glucosidase.. Protein science : a publication of the Protein Society, 27 ((8)): (1498-1508). [PMID:29761590]
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25. Zhi Xiang Ng,Nureen Farhana Rosman. (2019-03-25) In vitro digestion and domestic cooking improved the total antioxidant activity and carbohydrate-digestive enzymes inhibitory potential of selected edible mushrooms.. Journal of food science and technology, 56 ((2)): (865-877). [PMID:30906044]
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27. Shipra Bhansali,Anil Bhansali,Pinaki Dutta,Rama Walia,Veena Dhawan. (2020-01-25) Metformin upregulates mitophagy in patients with T2DM: A randomized placebo-controlled study.. Journal of cellular and molecular medicine, 24 ((5)): (2832-2846). [PMID:31975558]
28. Junichi Kato,Yohei Shirakami,Taku Mizutani,Masaya Kubota,Hiroyasu Sakai,Takashi Ibuka,Masahito Shimizu. (2020-03-27) Alpha-Glucosidase Inhibitor Voglibose Suppresses Azoxymethane-Induced Colonic Preneoplastic Lesions in Diabetic and Obese Mice.. International journal of molecular sciences, 21 ((6)): (). [PMID:32210144]
29. Xiaolong Chen,Yuguo Zheng,Yinchu Shen. (2006-02-07) Voglibose (Basen, AO-128), one of the most important alpha-glucosidase inhibitors.. Current medicinal chemistry, 13 ((1)): (109-116). [PMID:16457643]
30. Makoto Hiki,Kazunori Shimada,Takashi Kiyanagi,Kosuke Fukao,Kuniaki Hirose,Hiromichi Ohsaka,Yoshifumi Fukushima,Atsumi Kume,Rie Matsumori,Katsuhiko Sumiyoshi,Tetsuro Miyazaki,Hirotoshi Ohmura,Takeshi Kurata,Takashi Miida,Hiroyuki Daida. (2010-06-04) Single administration of alpha-glucosidase inhibitors on endothelial function and incretin secretion in diabetic patients with coronary artery disease - Juntendo University trial: effects of miglitol on endothelial vascular reactivity in type 2 diabetic patients with coronary heart disease (J-MACH) -.. Circulation journal : official journal of the Japanese Circulation Society, 74 ((7)): (1471-1478). [PMID:20519875]
31. Y Iwamoto,N Tajima,T Kadowaki,K Nonaka,T Taniguchi,M Nishii,J C Arjona Ferreira,J M Amatruda. (2010-07-02) Efficacy and safety of sitagliptin monotherapy compared with voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind trial.. Diabetes, obesity & metabolism, 12 ((7)): (613-622). [PMID:20590736]
32. Xiu-mei Dai,Ning An,Jian-min Wu,Hui-yi Li,Qi-ming Zhang. (2011-02-26) Development and validation of HPLC-UV-MS method for the control of four anti-diabetic drugs in suspected counterfeit products.. Yao xue xue bao = Acta pharmaceutica Sinica, 45 ((3)): (347-352). [PMID:21348424]
33. Keisuke Fujitaka,Hajime Otani,Fusakazu Jo,Hiromi Jo,Emiko Nomura,Masayoshi Iwasaki,Mitsushige Nishikawa,Toshiji Iwasaka. (2011-04-19) Comparison of metabolic profile and adiponectin level with pioglitazone versus voglibose in patients with type-2 diabetes mellitus associated with metabolic syndrome.. Endocrine journal, 58 ((6)): (425-432). [PMID:21498915]
34. Ryuzo Kawamori. (2011-07-20) [Evidence demonstrating the effect of voglibose for the prevention of type 2 diabetes mellitus: a randomised double-blind trial in Japanese subjects with inpaired glucose tolerance].. Nihon rinsho. Japanese journal of clinical medicine, 69 Suppl 1 (): (663-670). [PMID:21766678]
35. T Narita,H Yokoyama,R Yamashita,T Sato,M Hosoba,T Morii,H Fujita,K Tsukiyama,Y Yamada. (2011-11-05) Comparisons of the effects of 12-week administration of miglitol and voglibose on the responses of plasma incretins after a mixed meal in Japanese type 2 diabetic patients.. Diabetes, obesity & metabolism, 14 ((3)): (283-287). [PMID:22051162]
36. Yu Kataoka,Satoshi Yasuda,Yoshihiro Miyamoto,Kazuhiro Sase,Masami Kosuge,Kazuo Kimura,Yasunao Yoshimasa,Shunichi Miyazaki. (2012-01-14) Effects of voglibose and nateglinide on glycemic status and coronary atherosclerosis in early-stage diabetic patients.. Circulation journal : official journal of the Japanese Circulation Society, 76 ((3)): (712-720). [PMID:22240597]
37. Eberhard Standl,Oliver Schnell. (2012-04-18) Alpha-glucosidase inhibitors 2012 - cardiovascular considerations and trial evaluation.. Diabetes & vascular disease research, 9 ((3)): (163-169). [PMID:22508699]
38. Tomoko Kimura,Jinya Suzuki,Mai Ichikawa,Michiko Imagawa,Satsuki Sato,Miki Fujii,Yasuo Zenimaru,Satoru Inaba,Sadao Takahashi,Tadashi Konoshita,Isamu Miyamori. (2012-04-24) Differential effects of α-glucosidase inhibitors on postprandial plasma glucose and lipid profile in patients with type 2 diabetes under control with insulin lispro mix 50/50.. Diabetes technology & therapeutics, 14 ((7)): (545-551). [PMID:22519736]
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42. Ho-Sook Kim,Minkyung Oh,Eun Ji Kim,Geun Seog Song,Jong-Lyul Ghim,Ji-Hong Shon,Dong-Hyun Kim,Jae-Gook Shin. (2014-08-28) Effect of voglibose on the pharmacokinetics of metformin in healthy Korean subjects.. International journal of clinical pharmacology and therapeutics, 52 ((11)): (1005-1011). [PMID:25161160]
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47. Kentaro Ejiri,Toru Miyoshi,Hajime Kihara,Yoshiki Hata,Toshihiko Nagano,Atsushi Takaishi,Hironobu Toda,Seiji Nanba,Yoichi Nakamura,Satoshi Akagi,Satoru Sakuragi,Taro Minagawa,Yusuke Kawai,Nobuhiro Nishii,Soichiro Fuke,Masaki Yoshikawa,Kazufumi Nakamura,Hiroshi Ito. (2020-08-18) Effect of Luseogliflozin on Heart Failure With Preserved Ejection Fraction in Patients With Diabetes Mellitus.. Journal of the American Heart Association, 9 ((16)): (e015103-e015103). [PMID:32805185]
48. Pooja Shah,Vishal Chavda,Snehal Patel,Shraddha Bhadada,Ghulam Md Ashraf. (2020-10-16) Promising Anti-stroke Signature of Voglibose: Investigation through In- Silico Molecular Docking and Virtual Screening in In-Vivo Animal Studies.. Current gene therapy, 20 ((3)): (223-235). [PMID:33054705]

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伏格列波糖

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基本描述

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化学和物理性质

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伏格列波糖

库存信息

库存信息

库存信息

基本描述

名称和标识符

化学和物理性质

安全信息

参考文献

相关文档

质检报告COA

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产品问答

91高清自产国产拍,无码免费A级毛片大全,日本 欧美 国产中文字幕,99re热视频这里只有精品视频首页

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