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化学和生化试剂
生化试剂
多肽
醋酸阿肽地尔

醋酸阿肽地尔

参与神经传递和平滑肌松弛

规格或纯度: ≥95% (HPLC)

CAS编号: 40077-57-4
分子式: C₁₄₇H₂₃₈N₄₄O₄₂S·C₂H₄O₂
分子量: 3385.90
MDL号: MFCD00167535
PubChem编号: 85090371

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货号 (SKU)	包装规格	是否现货	价格	数量
V118951-0.5mg	0.5mg	现货
V118951-1mg	1mg	现货
V118951-2.5mg	2.5mg	现货
V118951-5mg	5mg	现货
V118951-25mg	25mg	期货

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基本描述

规格或纯度	≥95% (HPLC)
英文名称	Aviptadil acetate
别名	血管活性肠肽
英文别名	VIP His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
生化机理	Neuropeptide that is widely distributed in the central and peripheral nervous systems. It is a vasodilator, bronchodilator and smooth muscle relaxant. It modulates the activity of many immune system cell types. It is a mitogen for embryonic sympathetic neurons. Its neuroprotective actions are mediated by the release of activity-dependent neurotrophic factors from glial cells. Vasoactive Intestinal Peptide human, porcine, rat (VIP) is a neuropeptide synthesized in the central nervous system that enhances the formation of adenosine 3′,5′-cyclic monophosphate in cerebral cortex and hypothalamus of chick and rat. VIP modulates the cholinergic as well as serotonergic neurotransmitter systems.
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	0.5mg/2.5mg卖完停产，不再备货
产品介绍	产品介绍 Vasoactive Intestinal Peptide (VIP) is expressed in airway epithelial cells, secretory glands, immune and inflammatory cells. It functions as a neuroendocrine hormone and putative neurotransmitter. It stimulates neuronal survival and modulates glycogen metabolism. VIP blocks mitogen-activated proliferation of T cells by preventing interleukin-2 production. It promotes electrolyte secretion and provides protection against oxidant injury. 用途 Vasoactive Intestinal Peptide human, porcine, rat has been used to study its ability to stimulate adenosine 3′,5′-cyclic monophosphate (cyclic AMP) formation in the hypothalamus and cerebral cortex of chick and rats. Vasoactive Intestinal Peptide human, porcine, rat was used to treat human donor corneoscleral explants to maintain corneal endothelial (CE) integrity during eye banking.The product was also used as a test compound for studying its impact on swimbladder blood flow by using saline- or blood-perfused swimbladder preparations of the freshwater European eel Anguilla Anguilla. Product Introduction Vasoactive Intestinal Peptide (VIP) is expressed in airway epithelial cells, secretory glands, immune and inflammatory cells. It functions as a neuroendocrine hormone and putative neurotransmitter. It stimulates neuronal survival and modulates glycogen metabolism. VIP blocks mitogen-activated proliferation of T cells by preventing interleukin-2 production. It promotes electrolyte secretion and provides protection against oxidant injury. Application Vasoactive Intestinal Peptide human, porcine, rat has been used to study its ability to stimulate adenosine 3′,5′-cyclic monophosphate (cyclic AMP) formation in the hypothalamus and cerebral cortex of chick and rats. Vasoactive Intestinal Peptide human, porcine, rat was used to treat human donor corneoscleral explants to maintain corneal endothelial (CE) integrity during eye banking.The product was also used as a test compound for studying its impact on swimbladder blood flow by using saline- or blood-perfused swimbladder preparations of the freshwater European eel Anguilla Anguilla.

名称和标识符

分子式	C₁₄₇H₂₃₈N₄₄O₄₂S·C₂H₄O₂
关联CAS	1444827-29-5
PubChem CID	85090371
分子量	3385.90

数据库链接

PubChem CID	16132300
CAS Registry No.	40077-57-4

化学和物理性质

溶解性	Soluble to 1 (mg/mL) in water}

关联配体

Ligand ID	10891
名称	aviptadil
别名	Invicorp® (aviptadil + phentolamine)
类别	Peptide
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Aviptadil is a vasoactive intestinal peptide analogue, VPAC1 receptor agonist.
单字母多肽序列	HSDAVFTDNYTRLRKQMAVKKYLNSILN
三字母多肽序列	H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-aspartamide
翻译后修饰
化学修饰
临床描述	Novel Corona Virus (COVID-19) is known to cause Acute Lung Injury/Acute Respiratory Distress Syndrome, that results in death of approximately 80% of those who develop ARDS, despite intensive care and mechanical ventilation. Patients with COVID-19 induced Acute Respiratory Distress Syndrome who are admitted for intensive care including endotracheal intubation and mechanical ventilation will be treated with Aviptadil, a synthetic form of Human Vasoactive Intestinal Polypeptide (VIP) plus maximal intensive care vs. placebo + maximal intensive care. Patients will be randomized to intravenous Aviptadil will receive escalating doses from 50 -150 pmol/kg/hr over 12 hours. Brief Summary: SARS-CoV-2 virus infection is known to cause Lung Injury that begins as dyspnea and exercise intolerance, but may rapidly progress to Acute Respiratory Distress Syndrome and the need for mechanical ventilation. Mortality rates as high as 80% have been reported among those who develop ARDS, despite intensive care and mechanical ventilation. Patients with COVID-19 induced non-Acute Lung Injury who have demonstrated reduction in blood oxygenation, dyspnea, and exercise intolerance but do not require endotracheal intubation and mechanical ventilation will be treated with Aviptadil, a synthetic version of Vasoactive Intestinal Polypeptide (VIP) plus Standard of Care vs. placebo + Standard of Care. Patients will be randomized to intravenous Aviptadil will receive inhaled Aviptadil, 100 μg 3x daily vs. placebo 3x daily. The primary outcome will be progression to ARDS over 28 days. Secondary outcomes will include blood oxygenation as measured by pulse oximetry, dyspnea, exercise tolerance, and levels of TNFα IL-6 and other cytokines.
来源公司	NeuroRx, Inc. NeuroRx, Inc.

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