硫酸长春新碱

微管抑制剂

规格或纯度: 98%

CAS编号: 2068-78-2
分子式: C₄₆H₅₆N₄O₁₀·H₂SO₄
分子量: 923.04
Beilstein号: 3924631
EC号: 218-190-0
MDL号: MFCD00084729
PubChem编号: 249332

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货号 (SKU)	包装规格	是否现货
V107236-25mg	25mg	现货
V107236-100mg	100mg	现货
V107236-500mg	500mg	现货
V107236-1g	1g	现货
V107236-5g	5g	现货

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基本描述

规格或纯度	98%
英文名称	Vincristine sulfate
别名	硫酸醛基长春碱,硫酸长春醛碱
英文别名	22-Oxovincaleukoblastine sulfate salt Leurocristine sulfate salt VCR
生化机理	Vincristine is a plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing coiled spiral aggregate formation. It arrests cell cycle in G2/M-phase by blocking mitotic spindle formation. Vincristine triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. It inhibits VEGF production in leukemia cell lines. It is a substrate for Pgp and CYP3A4. MRP1 transports vincristine in an ATP- and GSH-dependent manner. Vincristine has some immunosuppressant effect. Vincristine may also interfere with amino acid, cyclic AMP, and glutathione metabolism, calmodulin-dependent Ca2+-transport, cellular respiration, and nucleic acid and lipid biosynthesis.Anticancer agent; microtubule depolymerizer.
储存温度	-20°C储存,充氩
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	水溶性:＞=1 g/100 mL at 24℃ 广泛地用于癌症研究，多药物抑制，单胺氧化酶（monoamine oxidase）抑制剂。

名称和标识符

EC号	218-190-0
IUPAC Name	methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid
INCHI	InChI=1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1
InChi Key	AQTQHPDCURKLKT-JKDPCDLQSA-N
Canonical SMILES	CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O
分子式	C₄₆H₅₆N₄O₁₀·H₂SO₄
UN Number	2811
PubChem CID	249332
Beilstein号	3924631
分子量	923.04

化学和物理性质

溶解性	Soluble in DMSO at 60mg/ml. Soluble in water at 25mg/ml with warming. Very poorly soluble in ethanol
敏感性	易吸潮;对光线敏感
熔点	300 °C

安全信息

象形图	Toxic Health Hazard
信号词	Danger
危险声明	H341: Suspected of causing genetic defects H300: Fatal if swallowed H361: Suspected of damaging fertility or the unborn child
预防措施声明	P280,P321,P405,P501,P264,P281,P270,P330,P203,P301+P316,P318
Merck Index	9986

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