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羟钴胺盐酸盐
规格或纯度:
90%
- CAS编号: 78091-12-0
- 分子式: C62H89CoN13O15P﹒x(HCl)
- 分子量: 1346.32（free base）
- EC号: 261-200-3
- MDL号: MFCD00167463
- PubChem编号: 5488668
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基本描述
| 规格或纯度 | 90% |
|---|---|
| 英文名称 | Hydroxocobalamin hydrochloride |
| 别名 | 维生素 B 12a |
| 英文别名 | Vitamin B12a hydrochloride；OH-Cbl HCl；α-(5,6-Dimethylbenzimidazolyl)hydroxocobamide hydrochloride；Aquocobalamin chloride |
| 生化机理 | Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms. Bacteria-derived hydroxocobalamin (OHCbl) and CNCbl are converted in humans to useful coenzyme forms to support metabolic processes such as mitochondrial methylmalonylcoenzyme A mutase conversion of methylmalonic acid (MMA) to succinate to link lipid and carbohydrate metabolism, and activation of methionine synthase, the rate limiting step in the synthesis of methionine. |
| 储存温度 | 2-8°C储存,充氩 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
application： Vitamin B12a hydrochloride has been used as an antidote for cyanide poisoning.? ? |
名称和标识符
| EC号 | 261-200-3 |
|---|---|
| IUPAC Name | cobalt(3+);[5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 1-[3-[(5Z,10Z,14Z)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-1,2,7,12,17,23-hexahydrocorrin-3-yl]propanoylamino]propan-2-yl phosphate;hydroxide;hydrochloride |
| INCHI | InChI=1S/C62H90N13O14P.ClH.Co.H2O/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;;/h20-21,23,28,31,34-37,41,52-53,56-57,71,76,84H,12-19,22,24-27H2,1-11H3,(H2,63,77)(H2,64,78)(H2,65,79)(H2,66,80)(H2,67,81)(H2,68,82)(H,69,83)(H,85,86);1H;;1H2/q;;+3;/p-2/b38-23-,50-32-,55-33-;;; |
| InChi Key | CGILFMTUCMTNCZ-MAQCMGFJSA-L |
| Canonical SMILES | CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=N6)C(=C7C(C(C(=CC8=NC(=C(C4=N5)C)C(C8(C)C)CCC(=O)N)N7)CCC(=O)N)(C)CC(=O)N)C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[OH-].Cl.[Co+3] |
| 分子式 |
C62H89CoN13O15P﹒x(HCl) |
| 关联CAS | 58288-50-9 |
| PubChem CID | 5488668 |
| 分子量 | 1346.32（free base） |
化学和物理性质
| 溶解性 | methanol: 10 mg/mL at 20 °C, clear, dark red |
|---|---|
| 敏感性 | 对光敏感;对湿度敏感 |
安全信息
| WGK Germany | 3 |
|---|---|
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
参考文献
| 1. Mamoru Yamanishi,Monica Vlasie,Ruma Banerjee. (2005-06-14) Adenosyltransferase: an enzyme and an escort for coenzyme B12?. Trends in biochemical sciences, 30 ((6)): (304-308). [PMID:15950874] |
| 2. Ruma Banerjee. (2006-12-14) B12 trafficking in mammals: A for coenzyme escort service.. ACS chemical biology, 1 ((3)): (149-159). [PMID:17163662] |
| 3. Luciana Hannibal,Jihoe Kim,Nicola E Brasch,Sihe Wang,David S Rosenblatt,Ruma Banerjee,Donald W Jacobsen. (2009-05-19) Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product.. Molecular genetics and metabolism, 97 ((4)): (260-266). [PMID:19447654] |
| 4. Jihoe Kim,Luciana Hannibal,Carmen Gherasim,Donald W Jacobsen,Ruma Banerjee. (2009-10-06) A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins.. The Journal of biological chemistry, 284 ((48)): (33418-33424). [PMID:19801555] |
| 5. Karl Gruber,Barbara Puffer,Bernhard Kr?utler. (2011-06-21) Vitamin B12-derivatives-enzyme cofactors and ligands of proteins and nucleic acids.. Chemical Society reviews, 40 ((8)): (4346-4363). [PMID:21687905] |
| 6. Markos Koutmos,Carmen Gherasim,Janet L Smith,Ruma Banerjee. (2011-06-24) Structural basis of multifunctionality in a vitamin B12-processing enzyme.. The Journal of biological chemistry, 286 ((34)): (29780-29787). [PMID:21697092] |
| 7. Hitesh V Motwani,Margareta T?rnqvist. (2014-12-03) In vivo doses of butadiene epoxides as estimated from in vitro enzyme kinetics by using cob(I)alamin and measured hemoglobin adducts: an inter-species extrapolation approach.. Toxicology and applied pharmacology, 281 ((3)): (276-284). [PMID:25448046] |
| 8. C M Miller,S Ganesh,C B Garland,D M Leathwick. (2015-01-16) Production benefits from pre- and post-lambing anthelmintic treatment of ewes on commercial farms in the southern North Island of New Zealand.. New Zealand veterinary journal, 63 ((4)): (211-219). [PMID:25589215] |
| 9. Jasmin Federizon,Conrard Giresse Tetsassi Feugmo,Wei-Chiao Huang,Xuedan He,Kazutoyo Miura,Aida Razi,Joaquin Ortega,Mikko Karttunen,Jonathan F Lovell. (2021-01-21) Experimental and Computational Observations of Immunogenic Cobalt Porphyrin Lipid Bilayers: Nanodomain-Enhanced Antigen Association.. Pharmaceutics, 13 ((1)): (). [PMID:33466686] |
| 10. R Pace,M Bon Homme,R S Hoffman,D Lugassy. (2014-08-05) Effects of hydroxocobalamin on carboxyhemoglobin measured under physiologic and pathologic conditions.. Clinical toxicology (Philadelphia, Pa.), 52 ((7)): (647-650). [PMID:25089720] |
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