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熊果酸
规格或纯度:
≥90%
- CAS编号: 77-52-1
- 分子式: C30H48O3
- 分子量: 456.7
- Beilstein号: 2228563
- EC号: 201-034-0
- MDL号: MFCD00009621
- PubChem编号: 64945
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基本描述
| 规格或纯度 | ≥90% |
|---|---|
| 英文名称 | Ursolic acid |
| 生化机理 | 三萜类化合物存在于苹果等各类水果中，它是一种心脏保护剂和抗肿瘤剂。由于它能够抑制淀粉样蛋白β和CD36受体之间的相互作用，因此在研究中被用作潜在的阿尔茨海默氏病治疗剂。 |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
描述 熊果酸（UA）是一种羟基五环三萜酸（HPTA），具有抗菌、 抗癌、 抗氧化和抗炎作用。它还可以促进周围神经损伤后的神经再生。UA可以激活GABA能神经递质系统，从而延长睡眠持续时间。[GABA= γ-氨基丁酸] 应用 熊果酸可作为起始材料，用于与氯乙酸乙酯反应合成熊果酸乙氧甲酰基甲酯(ECU)。ECU可作为关键中间体，用于全合成重要的生物化合物3-乙酰基-2-[(未)取代苯基]-2,3-二氢-1,3,4-噁二唑-5-甲酯 3-O-乙酰基熊果酸。熊果酸也可用于制备新型杂环衍生物，以便进行各种活性研究。 Description Ursolic acid (UA) is a hydroxyl pentacyclic triterpenoic acid (HPTA), which exhibits anti-bacterial, anti-cancer, anti-oxidative and anti-inflammatory effects. It can also promote neuroregeneration after peripheral nerve injury. UA can enhance sleep duration by activating the GABAergic neurotransmitter system. [GABA= γ-aminobutyric acid]Ursolic acid can be used as a starting material to synthesize ethoxycarbonylmethyl ursolate (ECU) by reacting with ethyl chloroacetate. ECU is further used as a key intermediate in the total synthesis of a biologically important compound 3-acetyl-2-[(un)substituted phenyl]-2,3-dihydro-1,3,4-oxadiazol-5-Me 3-O-acetylursolate. Ursolic acid can also be used to prepare novel heterocyclic derivatives for various activity studies. |
名称和标识符
| EC号 | 201-034-0 |
|---|---|
| IUPAC Name | (1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid |
| INCHI | InChI=1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1 |
| InChi Key | WCGUUGGRBIKTOS-GPOJBZKASA-N |
| Canonical SMILES | CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1C)C)C(=O)O |
| PubChem CID | 64945 |
| 分子量 | 456.7 |
| Beilstein号 | 2228563 |
化学和物理性质
| 比旋光度 | 61° (C=1,Pyridine) |
|---|---|
| 熔点 | 283-285°C |
安全和危险性（GHS）
| Merck Index | 9890 |
|---|---|
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
产品问答
产品问答
参考文献
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| 20. Hao Zhang,Xiaolin Li,Jing Ding,Huae Xu,Xinzheng Dai,Zhibo Hou,Kai Zhang,Kun Sun,Weihao Sun. (2012-12-01) Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2).. International journal of pharmaceutics, 441 ((1-2)): (261-268). [PMID:23194884] |
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| 61. Chong Zhao,Shutao Yin,Yinhui Dong,Xiao Guo,Lihong Fan,Min Ye,Hongbo Hu. (2012-11-28) Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells.. Autophagy, 9 ((2)): (196-207). [PMID:23182854] |
| 62. Renata Nowak,Magdalena Wójciak-Kosior,Ireneusz Sowa,Anna Soko?owska-Krzaczek,Wioleta Pietrzak,Aleksandra Szczodra,Ryszard Kocjan. (2013-06-14) HPTLC-densitometry determination of triterpenic acids in Origanum vulgare, Rosmarinus officinalis and Syzygium aromaticum.. Acta poloniae pharmaceutica, 70 ((3)): (413-418). [PMID:23757931] |
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