熊果酸
规格或纯度:
10mM in DMSO
有货
规格或纯度 | 10mM in DMSO |
---|---|
英文名称 | Ursolic acid |
别名 | 乌苏酸 |
英文别名 | 3β-Hydroxy-12-ursen-28-ic acid |
生化机理 | Ursolic Acid, a naturally occurring triterpenoid, has been noted to demonstrate anti-angiogenic and anti-proliferative properties. Mechanistic studies suggest that this compound down-regulates MMP-2 and uPA expression in cells via inhibition of Akt, JNK, mammalian target of Rapamycin phosphorylation, and levels of NFκB protein in the nucleus. Other experiments have shown that Ursolic Acid may improve blood glucose, glucose tolerance, insulin tolerance, glycosylated hemoglobin, and plasma leptin levels in diabetic murine models. Additionally, this agent displays a capacity to induce cell cycle arrest and apoptosis through activation of p53 pathway and Bax protein, as well as down-regulation of Bcl-2. |
储存温度 | -80℃储存 |
运输条件 | 超低温冰袋运输 |
产品介绍 |
存在于天然植物中的一种三萜类化合物。不溶于水,溶于2%酒精的NaOH,溶于热冰醋酸,中度溶于丙酮,微溶于醇、醚、氯仿和二硫化碳。 Ursolic acid belongs to the class of triterpenoid compounds that occurs widely in medicinal herbs, food and other plants. It may possess pharmacological properties like hepta-protection, analgesic, cardiotonic, sedative and tonic effects. |
EC号 | 201-034-0 |
---|---|
IUPAC Name | (1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid |
INCHI | InChI=1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1 |
InChi Key | WCGUUGGRBIKTOS-GPOJBZKASA-N |
Canonical SMILES | CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1C)C)C(=O)O |
分子式 |
C30H48O3 |
PubChem CID | 64945 |
Beilstein号 | 2228563 |
分子量 | 456.7 |
敏感性 | 对空气敏感 |
---|---|
熔点 | 283-285°C |
比旋光度 | 61° (C=1,Pyridine) |
Merck Index | 9890 |
---|---|
个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |