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熊果酸

规格或纯度: 10mM in DMSO
有货

库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
U425908-1ml 1ml 现货 Stock Image

基本描述

规格或纯度 10mM in DMSO
英文名称 Ursolic acid
别名 乌苏酸
英文别名 3β-Hydroxy-12-ursen-28-ic acid
生化机理 Ursolic Acid, a naturally occurring triterpenoid, has been noted to demonstrate anti-angiogenic and anti-proliferative properties. Mechanistic studies suggest that this compound down-regulates MMP-2 and uPA expression in cells via inhibition of Akt, JNK, mammalian target of Rapamycin phosphorylation, and levels of NFκB protein in the nucleus. Other experiments have shown that Ursolic Acid may improve blood glucose, glucose tolerance, insulin tolerance, glycosylated hemoglobin, and plasma leptin levels in diabetic murine models. Additionally, this agent displays a capacity to induce cell cycle arrest and apoptosis through activation of p53 pathway and Bax protein, as well as down-regulation of Bcl-2.
储存温度 -80℃储存
运输条件 超低温冰袋运输
产品介绍

存在于天然植物中的一种三萜类化合物。不溶于水,溶于2%酒精的NaOH,溶于热冰醋酸,中度溶于丙酮,微溶于醇、醚、氯仿和二硫化碳。

Ursolic acid belongs to the class of triterpenoid compounds that occurs widely in medicinal herbs, food and other plants. It may possess pharmacological properties like hepta-protection, analgesic, cardiotonic, sedative and tonic effects.
An anti-angiogenic and anti-proliferative agent

名称和标识符

EC号 201-034-0
IUPAC Name (1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
INCHI InChI=1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
InChi Key WCGUUGGRBIKTOS-GPOJBZKASA-N
Canonical SMILES CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1C)C)C(=O)O
分子式

C30H48O3

PubChem CID 64945
Beilstein号 2228563
分子量 456.7

化学和物理性质

敏感性 对空气敏感
熔点 283-285°C
比旋光度 61° (C=1,Pyridine)

安全信息

Merck Index 9890
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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