| 规格或纯度 | ≥98% |
|---|---|
| 英文名称 | Uridine 5’-Diphospho-N-acetylglucosamine Disodium Salt |
| 别名 | 尿苷 5'-(三氢二磷酸酯) P'-[2-(乙酰氨基)-2-脱氧-alpha-D-吡喃葡萄糖基]酯钠盐(1:2)；5′-二磷酸尿嘧啶核苷-N-乙酰半乳糖胺二钠盐;UDP-GlcNAc；UDPAG；UDP-N-乙酰葡糖胺； |
| 英文别名 | UDP-N-acetylglucosamine;UDP-GlcNAc;UDPAG;Uridine 5'-(Trihydrogendiphosphate) P'-[2-(Acetylamino)-2-Deoxy-alpha-D-Glucopyranosyl] Ester Sodium Salt (1:2)；UDP-GlcNAc Disodium Salt；UDP-α-D-N-Acetylglucosamine Disodium Salt |
| 生化机理 | 供体底物可用于在合成N-聚糖中将GlcNAc转移至多萜醇前体。 UDP-GlcNAc还在O-GlcNAc信号转导中通过O-GlcNAc转移酶（OGT）作为与丝氨酸/苏氨酸残基连接的GlcNAc的来源。N聚糖合成中将GlcNAc转移至二元醇前体的供体底物。在O-GlcNAc信号转导中，还用作通过O-GlcNAc转移酶（OGT）连接到丝氨酸/苏氨酸残基的GlcNAc的来源。 |
| 应用 | Uridine 5′-diphospho-N-acetylglucosamine (UDP-GlcNAc) sodium salt has been used: · as a component of reaction cocktail in endoplasmic reticulum to Golgi transport assay · as a reference standard for the quantification of UDP-GlcNAc in liver tissues using high-performance liquid chromatography (HPLC) · in testing the glycosylation activity of O-GlcNAc transferase (OGT) against peptide substrate |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 备注 | 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| 产品介绍 |
Uridine 5′-diphospho-N-acetylglucosamine (UDP-GlcNAc) is a nucleotide sμgar. It is synthesized from glucose via the hexosamine biosynthetic pathway (HBP). UDP-GlcNAc is transported actively into Golgi, nucleotide sμgar transporter (NST). The levels of UDP-GlcNAc is modulated by the concentration of nutrients exposed to the cell.Uridine 5′-diphospho-N-acetylglucosamine (UDP-GlcNAc) sodium salt has been used: · as a component of reaction cocktail in endoplasmic reticulum to Golgi transport assay · as a reference standard for the quantification of UDP-GlcNAc in liver tissues using high-performance liquid chromatography (HPLC) · in testing the glycosylation activity of O-GlcNAc transferase (OGT) against peptide substrate Uridine 5′-diphospho-N-acetylglucosamine (UDP-GlcNAc) is a nucleotide sugar. It is synthesized from glucose via the hexosamine biosynthetic pathway (HBP). UDP-GlcNAc is transported actively into Golgi, nucleotide sugar transporter (NST). The levels of UDP-GlcNAc is modulated by the concentration of nutrients exposed to the cell. |
| EC号 | 293-820-5 |
|---|---|
| IUPAC Name | disodium;[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl] [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] phosphate |
| INCHI | InChI=1S/C17H27N3O17P2.2Na/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28;;/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28);;/q;2*+1/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-;;/m1../s1 |
| InChi Key | HXWKMJZFIJNGES-YZVFIFBQSA-L |
| Canonical SMILES | CC(=O)NC1C(C(C(OC1OP(=O)([O-])OP(=O)([O-])OCC2C(C(C(O2)N3C=CC(=O)NC3=O)O)O)CO)O)O.[Na+].[Na+] |
| 分子式 |
C17H25N3O17P2Na2 |
| PubChem CID | 16069658 |
| 分子量 | 651.32 |
| 溶解性 | DMSO: 10mM( < 1 mg/ml refers to the product slightly soluble or insoluble ) |
|---|
| 象形图 |
Harmful |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation |
| 预防措施声明 | P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319 |
| WGK Germany | 3 |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
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