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(±)-沙利度胺
免疫调节剂和抗癌剂
规格或纯度:
10mM in DMSO
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基本描述
| 别名 | 沙利度胺 |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Thalidomide |
| 生化机理 | Thalidomide was commonly used therapeutically in the late 1950’s, however, it was withdrawn from the market when it was discovered to cause birth defects. More recent research has found Thalidomide to affect key biochemical pathways yielding antiangiogenic and immunomodulatory activities. This compound has been shown to: selectively inhibit TNF α (tumor necrosis factor-α) biosynthesis and basic fibroblast growth factor (bFGF)-induced angiogenesis, induce apoptosis in human monocytes via a cytochrome c-dependent pathway, and to inhibit HIV-1 replication in a monocytoid (U1) line. These new found uses make Thalidomide an extremely valuable research tool.Immunomodulator. Antiproliferative, antiangiogenic and pro-apoptotic. |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
A selective inhibitor of TNF alpha biosynthesis shown to have immunomodulatory and antiangeogenic activity. A selective inhibitor of TNF alpha biosynthesis shown to have immunomodulatory and antiangeogenic activity. |
名称和标识符
| EC号 | 200-031-1 |
|---|---|
| IUPAC Name | 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
| INCHI | InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17) |
| InChi Key | UEJJHQNACJXSKW-UHFFFAOYSA-N |
| Canonical SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O |
| WGK Germany | 3 |
| RTECS | TI4375000 |
| PubChem CID | 5426 |
| UN Number | 2811 |
| Packing Group | I |
| 分子量 | 258.23 |
化学和物理性质
| 熔点 | 276 °C |
|---|
安全和危险性（GHS）
| 象形图 |
Health Hazard 
Harmful |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H302: Harmful if swallowed H360: May damage fertility or the unborn child |
| 预防措施声明 | P280,P405,P501,P264,P270,P330,P203,P301+P317,P318 |
| WGK Germany | 3 |
| RTECS | TI4375000 |
| Class | 6.1 |
| Merck Index | 9255 |
| 个人防护装备 | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
产品问答
产品问答
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