首页
400-620-6333
切换导航
搜索
基本描述
| 规格或纯度 | 10mM in DMSO |
|---|---|
| 英文名称 | Tenofovir |
| 生化机理 | Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections. |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Information Tenofovir (GS-1278) blocksreverse transcriptaseand hepatitis B virus infections. Tenofovir reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir also reduces the viral cytopathic effect of SIV(mac251) , SIV(B670) ,SHIV(89.6) and SHIV(RTSHIV). Tenofovir is uniquely active against multinucleoside-resistant HIV expressing the Q151M mutation, but shows reduced susceptibility to the T69S insertion mutations. Tenofovir inhibits hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. Tenofovir (4 μM) completely inhibits the growth of HIVIIIB in MT-2 cells. Tenofovir inhibits synthesis of negative strand strong-stop DNA with IC50 of 9 μM for wild-type RT, 6 μM for M184V RT and 50 μM for K65R RT. In?vivo Tenofovir (30 mg/kg) completely prevents SIV infection in all macaques without toxicity. Tenofovir treatment reduces plasma viral RNA levels to undetectable, with parallel decreases in the infectivity of plasma and infectious cells in peripheral blood mononuclear cells and cerebrospinal fluid (CSF) and stabilization of CD4+ T-cell numbers. Tenofovir (30 mg/kg, s.c.) completely abrogates HIV infection via intravaginal exposure in pig-tailed macaques. cell?lines：NSCLC cells Concentrations： Incubation?Time： Powder?Purity:≥99% |
名称和标识符
| Canonical SMILES | CC(C[N]1C=NC2=C(N)N=CN=C12)OC[P](O)(O)=O |
|---|---|
| 分子量 | 287.21 |
化学和物理性质
| 溶解性 | Solubility (25°C) In vitro Ethanol: mg/mL ? ? |
|---|
产品问答
产品问答
上海阿拉丁生化科技股份有限公司
? 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任
危险品化学品经营许可证（带存储）