Cas(67526-95-8), 毒胡萝卜素-阿拉丁试剂, Thapsigargin;Octanoic acid,Thapsigargin,

货号 (SKU)	包装规格	是否现货
T135258-1mg	1mg	现货
T135258-5mg	5mg	现货
T135258-10mg	10mg	现货

基本描述

规格或纯度	≥95%
英文名称	Thapsigargin
英文别名	octanoic acid {3S-[3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha(Z),9balpha]}-6-(acetoxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)-azuleno[4,5-b]furan-7-yl ester
生化机理	Potent, cell-permeable, IP3-independent intracellular calcium releaser. Blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. Induces apoptosis by disrupting intracellular free Ca2+ levels; incorporated into chemotherapeutic prodrμg formulations.A potent, cell-permeable Ca 2+ -ATPase inhibitor. Releases Ca 2+ by inhibiting endoplasmic reticular Ca 2+ -ATPase (IC 50 = 4-13 nM). Both tumorogenic and apoptotic actions reported.
储存温度	避光,-20°C储存,充氩
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	Thapsigargin is a cell-permeable sesquiterpene lactone found in the roots of Thapsia garganica. It is a tumor promoter and induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA; IC50=30 nM). It may be used to distinguish between discrete intracellular Ca2+ pools. Thapsigargin-induced tumor promotion and down regulation of the EGF receptor is independent of protein kinase C activation.An inducer of stored Ca2+ release. Thapsigargin is a cell-permeable sesquiterpene lactone found in the roots of Thapsia garganica. It is a tumor promoter and induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA; IC50=30 nM). It may be used to distinguish between discrete intracellular Ca2+ pools. Thapsigargin-induced tumor promotion and down regulation of the EGF receptor is independent of protein kinase C activation. An inducer of stored Ca2+ release.

名称和标识符

IUPAC Name	[(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate
INCHI	InChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
InChi Key	IXFPJGBNCFXKPI-FSIHEZPISA-N
Canonical SMILES	CCCCCCCC(=O)OC1C2C(=C(C1OC(=O)C(=CC)C)C)C3C(C(CC2(C)OC(=O)C)OC(=O)CCC)(C(C(=O)O3)(C)O)O
分子式	C₃₄H₅₀O₁₂
PubChem CID	446378
分子量	650.75

数据库链接

Wikipedia	Thapsigargin
CAS Registry No.	67526-95-8
ChEBI	CHEBI:9516
PubChem CID	446378
ChEMBL Ligand	CHEMBL96926
RCSB PDB Ligand	TG1

化学和物理性质

溶解性	Soluble in DMSO (20 mg/ml), ethanol (20 mg/ml), and acetone
敏感性	对光敏感;对湿度敏感

安全信息

象形图	Health Hazard Harmful
信号词	Danger
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P284,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319,P342+P316
WGK Germany	3
个人防护装备	dust mask type N95 (US), Eyeshields, Faceshields, Gloves

关联配体

Ligand ID	5351
名称	thapsigargin
类别	Natural product
学名	(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2H,3H,3aH,4H,5H,6H,6aH,7H,8H,9bH-azuleno[4,5-b]furan-7-yl octanoate
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth.

参考文献

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毒胡萝卜素

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基本描述

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化学和物理性质

安全信息

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参考文献

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毒胡萝卜素

库存信息

库存信息

库存信息

基本描述

名称和标识符

数据库链接

化学和物理性质

安全信息

关联配体

参考文献

相关文档

质检报告COA

相关技术文章

产品问答

产品问答

91高清自产国产拍,无码免费A级毛片大全,日本 欧美 国产中文字幕,99re热视频这里只有精品视频首页

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