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1,2,3,4-四氢-β-咔啉

规格或纯度: 96%
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货号 (SKU) 包装规格 是否现货 价格 数量
T131784-250mg 250mg 现货 Stock Image
T131784-1g 1g 现货 Stock Image
T131784-5g 5g 现货 Stock Image
T131784-10g 10g 期货 Stock Image
T131784-25g 25g 现货 Stock Image

基本描述

规格或纯度 96%
英文名称 1,2,3,4-Tetrahydro-β-carboline
别名 1,2,3,4-四氢-9H-咔啉[3,4-B]吲哚;1,2,3,4-四氢-9H-吡啶并[3,4-b]吲哚;1,2,3,4-四氢-β-咔啉, 2,3,4,9-四氢-1H-吡啶并(3,4-b)吲哚
英文别名 Noreleagnine;THBC;Tetrahydronorharman;Tryptoline;Tetrahydro-beta-carboline
储存温度 避光
运输条件 常规运输
产品介绍

产品应用:

用于生物碱的合成以及用于研究神经退行性疾病。

Product Describtion:

Ozonolysis of the enamine bond of 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole derivatives was studied.


Product Application:

Reactant for synthesis of the indolyl-β-carboline alkaloid eudistomin U via IBX mediated room temperature oxidative aromatization

Reactant for preparation of neuroprotective HDAC6 inhibitors

Reactant for preparation of aminofuranopyrimidines as EGFR and Aurora A kinase inhibitors

Reactant for preparation of inhibitors of CDK4

Reactant for preparation of tetrahydrocarboline derivatives of as human 5-HT5A receptor ligands

Reactant for preparation of 5-(diaminomethyl)-2,4-aminopyrimidines as dihydrofolate reductase inhibitors and antibacterial agents

名称和标识符

IUPAC Name 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
INCHI InChI=1S/C11H12N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-4,12-13H,5-7H2
InChi Key CFTOTSJVQRFXOF-UHFFFAOYSA-N
Canonical SMILES C1CNCC2=C1C3=CC=CC=C3N2
分子式

C11H12N2

PubChem CID 107838
分子量 172.23

化学和物理性质

敏感性 对光线敏感

安全信息

象形图
ghs07

Harmful

信号词 Warning
危险声明 H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
预防措施声明 P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319
WGK Germany 3
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

参考文献

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2. Cláudia P B Martins,M Ali Awan,Sally Freeman,Tomás Herraiz,John F Alder,Simon D Brandt.  (2008-10-01)  Fingerprint analysis of thermolytic decarboxylation of tryptophan to tryptamine catalyzed by natural oils..  Journal of chromatography. A,  1210  ((1)):  (115-120).  [PMID:18823897]
3. Yusuke Ohta,Shinya Oishi,Nobutaka Fujii,Hiroaki Ohno.  (2009-04-10)  Facile synthesis of 1,2,3,4-tetrahydro-beta-carbolines by one-pot domino three-component indole formation and nucleophilic cyclization..  Organic letters,  11  ((9)):  (1979-1982).  [PMID:19354232]
4. Xuebin Chen,Brett A Cromer,Joseph W Lynch.  (2009-07-22)  Molecular determinants of beta-carboline inhibition of the glycine receptor..  Journal of neurochemistry,  110  ((5)):  (1685-1694).  [PMID:19619142]
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9. Nermin S Ahmed,Bernard D Gary,Hethar N Tinsley,Gary A Piazza,Stefan Laufer,Ashraf H Abadi.  (2011-03-09)  Design, synthesis and structure-activity relationship of functionalized tetrahydro-β-carboline derivatives as novel PDE5 inhibitors..  Archiv der Pharmazie,  344  ((3)):  (149-157).  [PMID:21384413]
10. Erhad Ascic,Casper L Hansen,Sebastian T Le Quement,Thomas E Nielsen.  (2012-03-01)  Synthesis of tetrahydro-β-carbolines via isomerization of N-allyltryptamines: a metal-catalyzed variation on the Pictet-Spengler theme..  Chemical communications (Cambridge, England),  48  ((27)):  (3345-3347).  [PMID:22367559]
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12. Gaofeng Cui,Benshui Shu,Sethuraman Veeran,Haiqi Yuan,Xin Yi,Guohua Zhong.  (2019-02-16)  Natural β-carboline alkaloids regulate the PI3K/Akt/mTOR pathway and induce autophagy in insect Sf9 cells..  Pesticide biochemistry and physiology,  154  ():  (67-77).  [PMID:30765058]
13. Bojan P Bondzic,Peter Eilbracht.  (2008-10-22)  Syntheses of tetrahydro-beta-carbolines via a tandem hydroformylation-Pictet-Spengler reaction. Scope and limitations..  Organic & biomolecular chemistry,  ((21)):  (4059-4063).  [PMID:18931815]
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15. J Brent Kuzmiski,Quentin J Pittman,Jaideep S Bains.  (2009-06-27)  Metaplasticity of hypothalamic synapses following in vivo challenge..  Neuron,  62  ((6)):  (839-849).  [PMID:19555652]
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20. Katherine S Ryan.  (2011-08-31)  Biosynthetic gene cluster for the cladoniamides, bis-indoles with a rearranged scaffold..  PloS one,  ((8)):  (e23694-e23694).  [PMID:21876764]
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