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(+)-δ-生育酚
规格或纯度:
90%
- CAS编号: 119-13-1
- 分子式: C27H46O2
- 分子量: 402.65
- EC号: 204-299-0
- MDL号: MFCD00067686
- PubChem编号: 92094
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基本描述
| 规格或纯度 | 90% |
|---|---|
| 英文名称 | (+)-δ-Tocopherol |
| 别名 | D-delta-Tocopherol |
| 英文别名 | D-delta-Tocopherol |
| 生化机理 | Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo. |
| 储存温度 | 2-8°C储存,充氩 |
| 运输条件 | 冰袋运输 |
名称和标识符
| EC号 | 204-299-0 |
|---|---|
| IUPAC Name | (2R)-2,8-dimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol |
| INCHI | InChI=1S/C27H46O2/c1-20(2)10-7-11-21(3)12-8-13-22(4)14-9-16-27(6)17-15-24-19-25(28)18-23(5)26(24)29-27/h18-22,28H,7-17H2,1-6H3/t21-,22-,27-/m1/s1 |
| InChi Key | GZIFEOYASATJEH-VHFRWLAGSA-N |
| Canonical SMILES | CC1=CC(=CC2=C1OC(CC2)(C)CCCC(C)CCCC(C)CCCC(C)C)O |
| 分子式 |
C27H46O2 |
| PubChem CID | 92094 |
| 分子量 | 402.65 |
化学和物理性质
| 密度 | 0.935 |
|---|
安全信息
| WGK Germany | 3 |
|---|---|
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
参考文献
| 1. Sontag TJ, Parker RS. (2002) Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status.. J Biol Chem, 277 (28): (25290-6). [PMID:11997390] |
| 2. K S Epler,R G Ziegler,N E Craft. (1993-09-08) Liquid chromatographic method for the determination of carotenoids, retinoids and tocopherols in human serum and in food.. Journal of chromatography, 619 ((1)): (37-48). [PMID:8245162] |
| 3. K S Sharpless,D L Duewer. (1995-12-01) Population distributions and intralaboratory reproducibility for fat-soluble vitamin-related compounds in human serum.. Analytical chemistry, 67 ((23)): (4416-4422). [PMID:8633780] |
| 4. R Brigelius-Flohé,M G Traber. (1999-07-01) Vitamin E: function and metabolism.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 13 ((10)): (1145-1155). [PMID:10385606] |
| 5. F P Cappuccio,E Rink,L Perkins-Porras,C McKay,S Hilton,A Steptoe. (2003-05-30) Estimation of fruit and vegetable intake using a two-item dietary questionnaire: a potential tool for primary health care workers.. Nutrition, metabolism, and cardiovascular diseases : NMCD, 13 ((1)): (12-19). [PMID:12772433] |
| 6. Alain Mavon,Véronique Raufast,Daniel Redoulès. (2004-11-17) Skin absorption and metabolism of a new vitamin E prodrug, delta-tocopherol-glucoside: in vitro evaluation in human skin models.. Journal of controlled release : official journal of the Controlled Release Society, 100 ((2)): (221-231). [PMID:15544870] |
| 7. Qing Jiang,Jeffrey Wong,Henrik Fyrst,Julie D Saba,Bruce N Ames. (2004-12-15) gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis.. Proceedings of the National Academy of Sciences of the United States of America, 101 ((51)): (17825-17830). [PMID:15596715] |
| 8. Chandan K Sen,Savita Khanna,Sashwati Roy. (2005-03-09) Tocotrienol: the natural vitamin E to defend the nervous system?. Annals of the New York Academy of Sciences, 1031 (): (127-142). [PMID:15753140] |
| 9. Christian P Fischer,Natalie J Hiscock,Samar Basu,Bengt Vessby,Anders Kallner,Lars-B?rje Sj?berg,Mark A Febbraio,Bente K Pedersen. (2005-12-31) Vitamin E isoform-specific inhibition of the exercise-induced heat shock protein 72 expression in humans.. Journal of applied physiology (Bethesda, Md. : 1985), 100 ((5)): (1679-1687). [PMID:16384840] |
| 10. Michael W Clarke,Natalie C Ward,Jason H Y Wu,Jonathan M Hodgson,Ian B Puddey,Kevin D Croft. (2006-01-10) Supplementation with mixed tocopherols increases serum and blood cell gamma-tocopherol but does not alter biomarkers of platelet activation in subjects with type 2 diabetes.. The American journal of clinical nutrition, 83 ((1)): (95-102). [PMID:16400056] |
| 11. Jana Cela,Caren Chang,Sergi Munné-Bosch. (2011-07-02) Accumulation of γ- rather than α-tocopherol alters ethylene signaling gene expression in the vte4 mutant of Arabidopsis thaliana.. Plant & cell physiology, 52 ((8)): (1389-1400). [PMID:21719428] |
| 12. Yun Wang,Michelle Moreland,James G Wagner,Bruce N Ames,Beate Illek,David B Peden,Qing Jiang. (2011-07-19) Vitamin E forms inhibit IL-13/STAT6-induced eotaxin-3 secretion by up-regulation of PAR4, an endogenous inhibitor of atypical PKC in human lung epithelial cells.. The Journal of nutritional biochemistry, 23 ((6)): (602-608). [PMID:21764283] |
| 13. Xiaofeng Fang, Gaozhan Zhao, Su Zhang, Yaoxi Li, Hanqing Gu, Yan Li, Qiao Zhao, Yijun Qi,. (2019-01-01) Chloroplast-to-Nucleus Signaling Regulates MicroRNA Biogenesis in Arabidopsis.. Developmental cell, 48 ((3)): ( 371-382 ). [PMID:30595534] |
| 14. Kirill Gorshkov,Manisha Pradhan,Miao Xu,Shu Yang,Emily M Lee,Catherine Z Chen,Min Shen,Wei Zheng. (2020-06-14) Cell-Based No-Wash Fluorescence Assays for Compound Screens Using a Fluorescence Cytometry Plate Reader.. The Journal of pharmacology and experimental therapeutics, 374 ((3)): (500-511). [PMID:32532853] |
| 15. M G Traber,H J Kayden. (1987-09-01) Tocopherol distribution and intracellular localization in human adipose tissue.. The American journal of clinical nutrition, 46 ((3)): (488-495). [PMID:3630967] |
| 16. Meilin Liu,Agneta Wallmon,Caroline Olsson-Mortlock,Rolf Wallin,Tom Saldeen. (2003-02-26) Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms.. The American journal of clinical nutrition, 77 ((3)): (700-706). [PMID:12600864] |
| 17. Siro Passi,Ornella De Pità,Mauro Grandinetti,Cristina Simotti,Gian Paolo Littarru. (2003-12-30) The combined use of oral and topical lipophilic antioxidants increases their levels both in sebum and stratum corneum.. BioFactors (Oxford, England), 18 ((1-4)): (289-297). [PMID:14695946] |
| 18. Jacqueline Limpens,Fritz H Schr?der,Corrina M A de Ridder,Cindy A Bolder,Mark F Wildhagen,Ute C Obermüller-Jevic,Klaus Kr?mer,Wytske M van Weerden. (2006-04-15) Combined lycopene and vitamin E treatment suppresses the growth of PC-346C human prostate cancer cells in nude mice.. The Journal of nutrition, 136 ((5)): (1287-1293). [PMID:16614418] |
| 19. Gabor Oláh,Katalin Módis,Domokos Gero,Kunihiro Suzuki,Douglas Dewitt,Daniel L Traber,Csaba Szabó. (2011-08-09) Cytoprotective effect of γ-tocopherol against tumor necrosis factor α induced cell dysfunction in L929 cells.. International journal of molecular medicine, 28 ((5)): (711-720). [PMID:21822532] |
| 20. Amanda K Smolarek,Nanjoo Suh. (2012-01-19) Chemopreventive activity of vitamin E in breast cancer: a focus on γ- and δ-tocopherol.. Nutrients, 3 ((11)): (962-986). [PMID:22254089] |
| 21. Laura L Baxter,Juan J Marugan,Jingbo Xiao,Art Incao,John C McKew,Wei Zheng,William J Pavan. (2012-07-24) Plasma and tissue concentrations of α-tocopherol and δ-tocopherol following high dose dietary supplementation in mice.. Nutrients, 4 ((6)): (467-490). [PMID:22822447] |
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