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粉防己碱

钙通道阻滞剂。抗炎和抗肿瘤药。

规格或纯度: 分析标准品,≥98%(HPLC),用于药物分析

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货号 (SKU)	包装规格	是否现货
T107322-20mg	20mg	现货
T107322-200mg	200mg	现货
T107322-1g	1g	现货

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六元杂环化合物吡啶类

规格或纯度	分析标准品,≥98%(HPLC),用于药物分析
英文名称	(S,S)-(+)-Tetrandrine
别名	汉防己碱,汉防己甲素
英文别名	tetrandrine\|518-34-3\|D-Tetrandrine\|(+)-Tetrandrine\|Tetrandrin\|Fanchinine\|Sinomenine A\|(S,S)-Tetrandrine\|Hanfangchin A\|hanjisong\|DL-Tetrandine\|NSC-77037\|NSC 77037\|(+-)-Tetrandine\|(S,S)-(+)-Tetrandrine\|d-Tetrandr\|CHEBI:49\|23495-89-8\|(+/-)-Tetrandrine\|S,S-(+
生化机理	钙通道阻滞剂。（对于L型和T型钙通道，IC 50值分别为8和20 μM）。多种药理作用。显示抗炎和抗肿瘤活性。在体内抑制破骨细胞分化。
应用	抗风湿与镇痛药，用于风湿、高血压、肺癌等。
运输条件	常规运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

IUPAC Name	(1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaene
INCHI	InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1
InChi Key	WVTKBKWTSCPRNU-KYJUHHDHSA-N
Canonical SMILES	CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC
WGK Germany	3
RTECS	XE9350000
PubChem CID	73078
分子量	622.75
Beilstein号	877811
Reaxy-Rn	79006

PubChem CID	73078
CAS Registry No.	518-34-3

密度	1.17
熔点	219-222°C

象形图	Toxic Harmful
信号词	Danger
危险声明	H302: Harmful if swallowed H300: Fatal if swallowed
预防措施声明	P321,P405,P501,P264,P270,P330,P301+P316,P301+P317
WGK Germany	3
RTECS	XE9350000
Reaxy-Rn	79006
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

Ligand ID	11859
名称	tetrandrine
别名	(+)-Tetrandrine
类别	Synthetic organic
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Tetrandrine is a compound that can be extracted from the Stephania tetrandra vine, or synthesised chemically. It has been demonstrated to act as an inhibitor of multiple ion channels, including two-pore channels 1 and 2 (TPC1/2), and L- and T-type calcium channels . The TPC calcium channels appear to be important for Ebola virus infection of host cells, and in vitro either ablation of TPC expression or tetrandrine-mediated inhibition of TPC channels reduces Ebola infection (IC₅₀ 55 nM) . SARS-CoV-2 infection (COVID-19): Tetrandrine is being studied in clinical trial for potential to treat COVID-19. The biological and pharmacological rationale for this use was reviewed in .
临床描述	The study is expected to treat patients with mild and severe neo-coronary pneumonia through standard treatment regimens in combination with tetrandrine tablets, thereby reducing the clinical progress of some patients, improving prognosis, reducing the incidence of pulmonary fibrosis during rehabilitation, and improving patients' quality of life.
来源公司	Henan Provincial People's Hospital

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在DMSO中的最大溶解度是多少

问题由程恺雯于 2023年5月18日 12:44 创建

您好！该产品不溶于水，在DMSO中的最大溶解度没有实测且会根据批次不同有少量差异，相关资料显示：溶剂DMSO，溶解度：5 mg/mL (8.03 mM; Need ultrasonic and warming)

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