DL-硫辛酸

非特异性自由基清除剂。抗氧化剂。

规格或纯度: 99%

CAS编号: 1077-28-7
分子式: C₈H₁₄O₂S₂
分子量: 206.33
Beilstein号: 81853
EC号: 214-071-2
MDL号: MFCD00005474
PubChem编号: 864

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货号 (SKU)	包装规格	是否现货
T106640-5g	5g	现货
T106640-25g	25g	现货
T106640-100g	100g	现货
T106640-500g	500g	现货

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化学预防剂

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基本描述

规格或纯度	99%
英文名称	DL-Thioctic acid
别名	α-硫辛酸；(±)-1,2-二硫戊环基-3-戊酸, DL-α-硫辛酸, Lip(S2), DL-6,8-硫辛酸, 6,8-二巯基辛酸
英文别名	DL-α-Lipoic Acid; DL-Thioctic Acid; 1,2-Dithiolane-3-valeric acid; DL-6,8-Dithiooctanoic acid; (±)-α-Lipoic acid; Lip(S2)
生化机理	维持酶复合物（例如丙酮酸脱氢酶和甘氨酸脱羧酶的复合物）活性所需的抗氧化剂和辅酶。通过两种或多种酶的作用在细胞内还原外源性硫辛酸。然后，该还原形式通过直接清除自由基、循环利用其他抗氧化剂、增加谷胱甘肽的合成以及调控转录因子（尤其是 NF-κB）的活性而影响许多细胞过程。减少巨噬细胞对髓磷脂的吞噬。非特异性自由基清除剂。防止脂质过氧化并促进体外线粒体通透性的转变。抗氧化剂。在体内和体外具有活性。
应用	抗氧化剂和作为如丙酮酸脱氢酶(pyruvate dehydrogenase）和甘氨酸脱羧酶（glycine decarboxylase）的辅酶，外源性硫辛酸被细胞内两种或多种酶还原。这种还原形式影响了细胞清除自由基的进程。增加谷胱甘肽(glutathione)合成, 调控转录因子活性。降低了巨噬细胞髓磷脂的吞噬作用。 α-LA可以恢复高脂肪喂养的糖尿病大鼠的内皮活动，并减轻氧化应激。它还用于分析星形胶质细胞中的ROS 产生。
储存温度	2-8°C储存,充氩
运输条件	冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	几乎无味。本品在水中几乎不溶，水中溶解度：1 g/L (20°C) 。溶于10% NaOH溶液，溶于脂肪族溶剂。在乙醇、氯仿、乙醚中易溶。? 抗氧化剂和作为如丙酮酸脱氢酶(pyruvate dehydrogenase）和甘氨酸脱羧酶（glycine decarboxylase）的辅酶，外源性硫辛酸被细胞内两种或多种酶还原。这种还原形式影响了细胞清除自由基的进程。增加谷胱甘肽(glutathione)合成, 调控转录因子活性。降低了巨噬细胞髓磷脂的吞噬作用。 α-LA可以恢复高脂肪喂养的糖尿病大鼠的内皮活动，并减轻氧化应激。它还用于分析星形胶质细胞中的ROS 产生。 α-Lipoic acid (LA), a nutritional component found in vegetables and meat, has both antioxidant and oxidant properties. LA exerts therapeutic potential to many diseases like liver cirrhosis, heavy metal poisoning, and diabetic polyneuropathy. LA exerts apoptotic potential in cancer cells either by oxidative stress related pathway or by activation of caspases. DL-Thioctic acid acid has been used in in vitro lipoylation studies and in the pyruvate dehydrogenase complex (PDC)-pyruvate dehydrogenase kinase (PDHK) functional assay.It has also been used to investigate its antioxidative effect on developing cerebellum of rats exposed to arsenic during postnatal period; DL-Thioctic acid can reinstate endothelial activities and alleviate oxidative stress in high-fat fed diabetic rats. It has also been used to analyze ROS production in astrocytes

名称和标识符

EC号	214-071-2
IUPAC Name	5-(dithiolan-3-yl)pentanoic acid
INCHI	InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)
InChi Key	AGBQKNBQESQNJD-UHFFFAOYSA-N
Canonical SMILES	C1CSSC1CCCCC(=O)O
分子式	C₈H₁₄O₂S₂
PubChem CID	864
Beilstein号	81853
分子量	206.33

化学和物理性质

溶解性	Soluble in methanol, ethanol, diethyl ether and chloroform. Insoluble in water.
敏感性	对空气&湿度&热&光敏感
沸点	160-165℃
熔点	62°C

安全信息

象形图	Environmental Hazard Harmful
信号词	Warning
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H411: Toxic to aquatic life with long lasting effects H302: Harmful if swallowed H317: May cause an allergic skin reaction
预防措施声明	P261,P305+P351+P338,P273,P280,P302+P352,P321,P501,P264,P270,P272,P333+P313,P362+P364,P391,P330,P264+P265,P301+P317,P337+P317,P332+P317
WGK Germany	3
RTECS	JP1192000
Reaxy-Rn	81851
Merck Index	9326
个人防护装备	dust mask type N95 (US),Eyeshields,Gloves

参考文献

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DL-硫辛酸

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化学和物理性质

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DL-硫辛酸

库存信息

库存信息

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库存信息

基本描述

名称和标识符

化学和物理性质

安全信息

参考文献

相关文档

质检报告COA

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