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SB 202190,p38 MAPK抑制剂

高选择性，有效的，细胞可渗透的p38 MAPK抑制剂
规格或纯度: 99%
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货号 (SKU) 包装规格 是否现货 价格 数量
S134307-5mg
 5mg 现货 Stock Image
S134307-25mg
 25mg 现货 Stock Image
S134307-100mg
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mitogen-activated protein kinase 14 Inhibitor
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基本描述

规格或纯度 99%
英文名称 SB 202190
别名 4-(4-氟苯基)-2-(4-羟基苯基)-5-(4-吡啶基)-1H-咪唑
英文别名 152121-30-7|SB 202190|SB202190|SB-202190|FHPI|4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole|SB202190 (FHPI)|4-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)phenol|4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole|CH
储存温度 2-8°C储存
运输条件 冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

SB 202190 is a pyridinyl imidazole that inhibits the p38 pathway. The compound inhibits the isoforms p38α and p38β. SB 202190 has displayed the ability to activate CPP32-like caspases and induce apoptosis. Research demonstrates that when one residue of ERK2, a related p38 not inhibited by pyridinyl imidazoles, is changed it allows SB 202190 to bind. Studies have revealed that SB 202190 can improve leukemia cell growth by activating MEK/MAPK, as well as phosphorylate and activate MLK3.An inhibitor of the isoforms p38α and p38β.

SB 202190 is a pyridinyl imidazole that inhibits the p38 pathway. The compound inhibits the isoforms p38α and p38β. SB 202190 has displayed the ability to activate CPP32-like caspases and induce apoptosis. Research demonstrates that when one residue of ERK2, a related p38 not inhibited by pyridinyl imidazoles, is changed it allows SB 202190 to bind. Studies have revealed that SB 202190 can improve leukemia cell growth by activating MEK/MAPK, as well as phosphorylate and activate MLK3.
An inhibitor of the isoforms p38α and p38β.

名称和标识符

IUPAC Name 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]phenol
INCHI InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
InChi Key QHKYPYXTTXKZST-UHFFFAOYSA-N
Canonical SMILES C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)O
分子式

C20H14FN3O
PubChem CID 5169
分子量 331.34

化学和物理性质

溶解性 Soluble in DMSO (66 mg/ml at 25 °C), methanol, DMF (~10 mg/ml), water (<1 mg/ml at 25 °C), and ethanol (32 mg/ml at 25 °C).

安全信息

象形图
ghs07

Harmful
信号词 Warning
危险声明 H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
预防措施声明 P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319
WGK Germany 3
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

靶标

Target ID 1499
名称 mitogen-activated protein kinase 14
缩写名 p38α
家族 p38 subfamily
别名 D7Ertd680e
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Human 2 360 6p21.31 MAPK14 mitogen-activated protein kinase 14
Mouse 2 360 17 14.85 cM Mapk14 mitogen-activated protein kinase 14
Rat 2 360 20p12 Mapk14 mitogen activated protein kinase 14
Ensembl Gene ENSG00000112062 (Hs) , ENSMUSG00000053436 (Mm) , ENSRNOG00000000513 (Rn)
Entrez Gene 26416 (Mm) , 81649 (Rn) , 1432 (Hs)
OMIM 600289 (Hs)
Protein GI 20986516 (Hs) , 270341386 (Mm) , 62461582 (Rn)
UniProtKB P47811 (Mm) , P70618 (Rn) , Q16539 (Hs)
RefSeq Nucleotide NM_001168508 (Mm) , NM_001315 (Hs) , NM_031020 (Rn)
RefSeq Protein NP_001161980 (Mm) , NP_001161985 (Mm) , NP_001161986 (Mm) , NP_001306 (Hs) , NP_036081 (Mm) , NP_112282 (Rn)
ChEMBL Target CHEMBL2336 (Mm) , CHEMBL4825 (Rn) , CHEMBL260 (Hs)

关联配体

Ligand ID 4307
名称 SB202190
别名 SB-202190
类别 Synthetic organic
学名 4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol
生物活性评价 We have been unable to find publicly available data showing inhibition of p38 MAPK isozymes other than indicated in the table below.
评价 SB202190 is a potent and selective p38 MAPK inhibitor, that preferentially inhibits p38α and p38β.

参考文献

1. Tamura Y et al..  (2021)  Anti-pyroptotic function of TGF-? is suppressed by a synthetic dsRNA analogue in triple negative breast cancer cells..  Mol Oncol,  15  (5):  (1289-1307).  [PMID:33342034]
2. Nunes JPS et al..  (2021)  Co-Exposure of Cardiomyocytes to IFN-? and TNF-a Induces Mitochondrial Dysfunction and Nitro-Oxidative Stress: Implications for the Pathogenesis of Chronic Chagas Disease Cardiomyopathy..  Front Immunol,  12  ():  (755862).  [PMID:34867992]
3. Ivshina MP et al..  (2022)  CPEB1 regulates the inflammatory immune response, phagocytosis, and alternative polyadenylation in microglia..  Glia,  70  (10):  (1850-1863).  [PMID:35635122]
4. Lu W et al..  (2016)  CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model..  Int J Mol Sci,  17  (10):  ().  [PMID:27690009]
5. Moore HM et al..  (2013)  EZH2 inhibition decreases p38 signaling and suppresses breast cancer motility and metastasis..  Breast Cancer Res Treat,  138  (3):  (741-52).  [PMID:23539298]
6. Hock EM et al..  (2018)  Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function..  Cell Rep,  24  (4):  (987-1000.e7).  [PMID:30044993]
7. ?rámek J et al..  (2016)  p38 MAPK Is Activated but Does Not Play a Key Role during Apoptosis Induction by Saturated Fatty Acid in Human Pancreatic ?-Cells..  Int J Mol Sci,  17  (2):  (159).  [PMID:26861294]
8. Tanaka T et al..  (2018)  Sec6 enhances cell migration and suppresses apoptosis by elevating the phosphorylation of p38 MAPK, MK2, and HSP27..  Cell Signal,  49  ():  (1-16).  [PMID:29729335]
9. Coricor G & Serra R.  (2016)  TGF-? regulates phosphorylation and stabilization of Sox9 protein in chondrocytes through p38 and Smad dependent mechanisms..  Sci Rep,  6  ():  (38616).  [PMID:27929080]

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