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基本描述
| 产品名称 | galectin 9 |
|---|
产品规格参数
| CAS编号和信息 | rp174096 |
|---|
数据库链接
| UniProtKB | O00182 |
|---|---|
| Ensembl Gene | ENSG00000168961 |
关联配体
| Ligand ID | 9594 |
|---|---|
| 名称 | galectin 9 |
| 别名 | Ecalectin |
| 类别 | Peptide |
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide |
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| 评价 |
Galectin 9 is a secreted lectin that is an endogenous ligand of the immune co-inhibitory receptor, TIM3. Galectins bind β-galactoside sugar modifications on proteins, and have been associated with metastasis and immunosuppression. Galectin 9 contains two tandem carbohydrate recognition domains (CRD) within its peptide structure. The CRDs are homologous but distinct in their primary sequence. The whole peptide sequence provided here is for the longest isoform reported to date. Uniprot records 6 human protein isoforms |
| 配体家族 | Galectins |
| 单字母多肽序列 | MAFSGSQAPYLSPAVPFSGTIQGGLQDGLQITVNGTVLSSSGTRFAVNFQTGFSGNDIAFHFNPRFEDGGYVVCNTRQNGSWGPEERKTHMPFQKGMPFDLCFLVQSSDFKVMVNGILFVQYFHRVPFHRVDTISVNGSVQLSYISFQNPRTVPVQPAFSTVPFSQPVCFPPRPRGRRQKPPGVWPANPAPITQTVIHTVQSAPGQMFSTPAIPPMMYPHPAYPMPFITTILGGLYPSKSILLSGTVLPSAQRFHINLCSGNHIAFHLNPRFDENAVVRNTQIDNSWGSEERSLPRKMPFVRGQSFSVWILCEAHCLKVAVDGQHLFEYYHRLRNLPTINRLEVGGDIQLTHVQT |
| 三字母多肽序列 | |
| 翻译后修饰 | |
| 化学修饰 |
参考文献
| 1. Hirashima M. (1999) Ecalectin as a T cell-derived eosinophil chemoattractant.. Int Arch Allergy Immunol, 120 Suppl 1 (13): (7-10). [PMID:10529594] |
| 2. Hirashima M. (2000) Ecalectin/galectin-9, a novel eosinophil chemoattractant: its function and production.. Int Arch Allergy Immunol, 122 Suppl 1 (13): (6-9). [PMID:10867499] |
| 3. Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, Manning S, Greenfield EA, Coyle AJ, Sobel RA et al.. (2002) Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease.. Nature, 415 (6871): (536-41). [PMID:11823861] |
| 4. Dunphy JL, Barcham GJ, Bischof RJ, Young AR, Nash A, Meeusen EN. (2002) Isolation and characterization of a novel eosinophil-specific galectin released into the lungs in response to allergen challenge.. J Biol Chem, 277 (17): (14916-24). [PMID:11839756] |
| 5. Hirashima M, Kashio Y, Nishi N, Yamauchi A, Imaizumi TA, Kageshita T, Saita N, Nakamura T. (2004) Galectin-9 in physiological and pathological conditions.. Glycoconj J, 19 (7-9): (593-600). [PMID:14758084] |
| 6. Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, Khoury SJ, Zheng XX, Strom TB, Kuchroo VK. (2005) The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity.. Nat Immunol, 6 (12): (1245-52). [PMID:16286920] |
| 7. Heusschen R, Freitag N, Tirado-González I, Barrientos G, Moschansky P, Mu?oz-Fernández R, Leno-Durán E, Klapp BF, Thijssen VL, Blois SM. (2013) Profiling Lgals9 splice variant expression at the fetal-maternal interface: implications in normal and pathological human pregnancy.. Biol Reprod, 88 (1): (22). [PMID:23242525] |
| 8. Heusschen R, Schulkens IA, van Beijnum J, Griffioen AW, Thijssen VL. (2014) Endothelial LGALS9 splice variant expression in endothelial cell biology and angiogenesis.. Biochim Biophys Acta, 1842 (2): (284-92). [PMID:24333696] |
| 9. Matsumoto R, Matsumoto H, Seki M, Hata M, Asano Y, Kanegasaki S, Stevens RL, Hirashima M. (1998) Human ecalectin, a variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes.. J Biol Chem, 273 (27): (16976-84). [PMID:9642261] |
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